FacultyDepartment of Biochemistry Ⅱ, Division of Innovative Research

Researcher Profile & Settings


    Overview of research:
    1. Mechanisms of regulation of alternative pre-mRNA processing 2. Molecular mechanisms of angiogenesis regulation 3. Identification of genes involved in neuro-vascular interaction 4. Molecular mechanisms of development of diabetic vascular complications

Special Field

  • General medical chemistry
  • Functional biochemistry
  • Functional biochemistry
  • Pathological medical chemistry


  • Nagoya University Graduate School Division of Medicine
  • Nagoya University Faculty of Science

Association Memberships

  • Nov. 2015Nov. 2017The Japanease Biochemical Society
  • 1985The Molecular Biology Society of Japan

Academic & Professional Experience

  • Apr. 1985Nov. 1990Kissei Pharmaceutical Co., Ltd. Researcher
  • Nov. 1990Nov. 1994Tohoku University Assistant professor
  • Dec. 1994Mar. 1996Tohoku University Associate professor
  • Apr. 1996Mar. 2006Kanazawa University Associate professor
  • Apr. 2006Kanazawa Medical University Professor

Research Activities

Published Papers

  • Role of Arginine Methylation in Alternative Polyadenylation of VEGFR-1 (Flt-1) pre-mRNA, Takayuki Ikeda, Hidehito Saito-Takatsuji, Yasuo Yoshitomi, Hideto Yonekura, International Journal of Molecular Sciences21:6460Sep. 2020
  • Ultraviolet B-induced Otx2 expression in lens epithelial cells promotes epithelial-mesenchymal transition, Yoshitomi Y, Osada H, Satake H, Kojima M, Saito-Takatsuji H, Ikeda T, Yoshitake Y, Ishigaki Y, Kubo E, Sasaki H, Yonekura H, Biology Open8:bio035691Feb. 2019
  • Effect of Collagen Tripeptide on Atherosclerosis in Healthy Humans., N.Tomosugi, S.Yamamoto, M.Takeuchi, H.Yonekura, Y.Ishigaki, N.Numata, S.Katsuda, Y.Sakai, Journal of atherosclerosis and thrombosis24:530-538May 2017
  • Effect of Collagen Tripeptide on Atherosclerosis in Healthy Humans, Naohisa Tomosugi, Shoko Yamamoto, Masayoshi Takeuchi, Hideto Yonekura, Yasuhito Ishigaki, Noriaki Numata, Shogo Katsuda, Yasuo Sakai, Journal of Atherosclerosis and Thrombosis24:530-538May 2017
  • JunB regulates angiogenesis and neurovascular parallel alignment in mouse embryonic skin, Y.Yoshitomi,T.Ikeda,H.Saito,Y.Yoshitake,Y.Ishigaki,T.Hatta,N.Kato,H.Yonekura, Jonal of Cell Science130:916-926Jan. 2017
  • Regulation of soluble Flt-1(VEGFR-1) production by hnRNP D and protein arginine methylation, T.Ikeda, Y.Yoshitomi, H.Saito, T.Shimasaki, H.Yamaya, T.Kobata, Y.Ishigaki, N.Tomosugi, Y.Yoshitake, H.Yonekura, Molecular and Cellular Biochemistry413:155-1642016
  • Melanocortins contribute to sequential differentiation and enucleation of human erythroblasts via melanocortin receptors 1, 2 and 5, E.Simamura, T.Arikawa, T.Ikeda, H.Shimada, H.Shoji, H,Masuta, Y.Nakajima, H.Otani, H.Yonekura, T.Hatta, PLoS One10:e0123232-e01232322015
  • Osteocytic cell necrosis is caused by a combination of glucocorticoid-induced Dickkopf-1 and hypoxia, S.Ueda, T.Ichiseki, Y.Yoshitomi, H.Yonekura, Y.Ueda, A.Kaneuji, T.Matsumoto, Medical Molecular Morphology48:69-75Jun. 2015
  • Low-molecular weight fractions of Japanese soy sauce act as a RAGE antagonist via inhibition of RAGE trafficking to lipid rafts., (S.Munesue), Y.Yamamoto, R.Urushihara, K.Inomata, H.Saito, S.Motoyoshi, T.Watanabe, H.Yonekura, H.Yamamoto, Food & function.4:1835-1842Dec. 2013
  • Low molecular weight heparin suppresses receptor for advanced glycation end products-mediated expression of malignant phenotype in human fibrosarcoma cells., (A.Takeuchi), Y.Yamamoto, S.Munesue, A.Harashima, T.Watanabe, H.Yonekura, H.Yamamoto, H.Tsuchiya, Cancer science.104:740-749Jun. 2013
  • Identification of a major enzyme for the synthesis and hydrolysis of cyclic ADP-ribose in amphibian cells and evolutional conservation of the enzyme from human to invertebrate, T.Ikeda, S.Takasawa, N.Noguchi, K.Nata, A.Yamauchi, I.Takahashi, T.Yoshikawa, A.Sugawara, H.Yonekura, H.Okamoto, Molecular and cellular biochemistry.366:69-80Jul. 2012
  • Loss of HITS(FAM107B) expression in cancers of multiple organs: tissue microarray analysis, (H.Nakajima), K.Koizumi, T.Tanaka, Y.Ishigaki, Y.Yoshitake, H.Yonekura, T.Sakuma, T.Fukushima, H.Umehara, S.Ueno, T.Minamoto, Y.Motoo, International journal of oncology41:1347-1357May 2012
  • Endogenous secretory receptor for advanced glycation end-products inhibits amyloid-β1-42 uptake into mouse brain, (T.Sugihara), S.Munesue, Y.Yamamoto, S.Sakurai, N.Akhter, Y.Kitamura, K.Shiba, T.Watanabe, H.Yonekura, Y.Hayashi, J.Hamada, H.Yamamoto, Journal of Alzheimer's disease : JAD28:709-720Feb. 2012
  • Suppression of a neocortical potassium channel activity by intracellular amyloid-β and its rescue with homer1a, K.Yamamoto, Y.Ueta, L.Wang, R.Yamamoto, N.Inoue, K.Inokuchi, A.Aiba, H.Yonekura, N.Kato, The Journal of neuroscience : the official journal of the Society for Neuroscience31:11100-11109Aug. 2011
  • Hypoxia down-regulates sFlt-1 (sVEGFR-1) expression in human microvascular endothelial cells by a mechanism involving mRNA alternative processing, T.Ikeda, L.Sun, N.Tsuruoka, Y.Ishigaki, Y.Yoshitomi, Y.Yoshitake, H.Yonekura, The Biochemical journal.436:399-407Jun. 2011
  • Identification of the COL2A1 mutation in patients with type I Stickler syndrome using RNA from freshly isolated peripheral white blood cells, H.Yaguchi, T.Ikeda, H.Osada, Y.Yoshitake, H.Sasaki, H.Yonekura, Genetic testing and molecular biomarkers.15:231-237Apr. 2011
  • Ultraviolet B-induced expression of amphiregulin and growth differentiation factor 15 in human lens epithelial cells, H.Osada, Y.Yoshitake, T.Ikeda, Y.Ishigaki, T.Takata, N.Tomosugi, H.Sasaki, H.Yonekura, Molecular vision17:159-169Jan. 2011
  • Septic shock is associated with receptor for advanced glycation end products ligation of LPS, (Y.Yamamoto), A.Harashima, H.Saito, K.Tsuneyama, S.Munesue, S.Motoyoshi, D.Han, T.Watanabe, M.Asano, S.Takasawa, H.Okamoto, S.Shimura, T.Karasawa, H.Yonekura, H.Yamamoto, Journal of immunology (Baltimore, Md. : 1950)186:3248-32572011
  • Regulation of alternative splicing of the receptor for advanced glycation endproducts (RAGE) through G-rich cis-elements and heterogenous nuclear ribonucleoprotein H, (K.Ohe), T.Watanabe, S.Harada, S.Munesue, Y.Yamamoto, H.Yonekura, H.Yamamoto, Journal of biochemistry.147:651-659May 2010
  • Induction of HITS, a newly identified family with sequence similarity 107 protein (FAM107B), in cancer cells by heat shock stimulation, H.Nakajima, Y.Ishigaki, QI-S.Xia, T.Ikeda, Y.Yoshitake, H.Yonekura, T.Nojima, T.Tanaka, H.Umehara, N.Tomosugi, T.Takata, T.Shimasaki, N.Nakaya, I.Sato, K.Kawakami, K.Koizumi, T.Minamoto, Y.Motoo, International journal of oncology37:583-5932010
  • Solution structure of the variable-type domain of the receptor for advanced glycation end products:new insight into AGE-RAGE interaction, (S.Matsumoto), T.Yoshida, H.Murata, S.Harada, N.Fujita, S.Nakamura, Y.Yamamoto, T.Watanabe, H.Yonekura, H.Yamamoto, T.Ohkubo, Y.Kobayashi, Biochemistry.47:12299-12311Nov. 2008
  • Reduced expression of endogenous secretory receptor for advanced glycation endproducts in hippocampal neurons of Alzheimer's disease brains, (I.Nozaki), T.Watanabe, M.Kawaguchi, H.Akatsu, K.Tsuneyama, Y.Yamamoto, K.Ohe, H.Yonekura, M.Yamada, H.Yamamoto, Archives of histology and cytology.70:279-290Dec. 2007
  • Promotion by collagen tripeptide of Type I collagen gene expression in human osteoblastic cells and fracture healing of rat femur, N.Tsuruoka, R.Yamato, Y.Sakai, Y.Yoshitake, H.Yonekura, Bioscience, biotechnology, and biochemistry71:2680-2687Nov. 2007
  • De-N-glycosylation or G82S mutation of RAGE sensitizes its interaction with advanced glycation endproducts, (M.Osawa), Y.Yamamoto, S.Munesue, N.Murakami, S.Sakurai, T.Watanabe, H.Yonekura, Y.Uchigata, Y.Iwamoto, H.Yamamoto, Biochimica et biophysica acta-molecular and cell biology of lipids1770:1468-1474Oct. 2007
  • Short-chain aldehyde-derived ligands for RAGE and their actions on endothelial cells, (Y.Yamamoto), H.Yonekura, T.Watanabe, S.Sakurai, H.Li, A.Harashima, KM.Myint, M.Osawa, A.Takeuchi, M.Takeuchi, H.Yamamoto, Diabetes research and clinical practice.77 (Suppl 1):S30-40Jun. 2007
  • Endogenous secretory receptor for advanced glycation endproducts as a novel prognostic marker in chondrosarcoma, (A.Takeuchi), Y.Yamamoto, K.Tsuneyama, C.Cheng, H.Yonekura, T.Watanabe, K.Shimizu, K.Tomita, H.Yamamoto, H.Tsuchiya, Cancer109:2532-2540Jun. 2007
  • Endogenous secretory receptor for advanced glycation endproducts levels are correlated with serum pentosidine and CML in patients with type 1 diabetes., (Miura, J.), Yamamoto, Y., Osawa, M., Watanabe, T., Yonekura, H., Uchigata, Y., Yamamoto, H., Iwamoto, Y., Arteriosclerosis, thrombosis, and vascular biology.27: 253-254Jan. 2007
  • RAGE in diabetic nephropathy, (H.Yamamoto), T.Watanabe, Y.Yamamoto, H.Yonekura, S.Munesue, A.Harashima, K.Ooe, S.Hossain, H.Saito, N.Murakami, Current molecular medicine7:752-7572007
  • Assaying soluble forms of receptor for advanced glycation end products. (Response), (Y.Yamamoto), J.Miura, S.Sakurai, T.Watanabe, H.Yonekura, H.Tamei, H.Matsuki, K.Obata, Y.Uchigata, Y. Iwamoto, H.Koyama, H.Yamamoto, Arteriosclerosis, thrombosis, and vascular biology.27:e33-342007
  • RAGE control of diabetic nephropathy in a mouse model: effects of RAGE gene disruption and administration of low-molecular weight heparin, (K.M.Myint), Y.Yamamoto, T.Doi, I.Kato, A.Harashima, H.Yonekura, T. Watanabe, H.Shinohara, M.Takeuchi, K. Tsuneyama, N.Hashimoto, M.Asano, S.Takasawa, H. Okamoto, H.Yamamoto, Diabetes.55:2510-2522Sep. 2006
  • Receptor for advanced glycation endproducts is involved in impaired angiogenic response in diabetes., (T. Shoji), H. Koyama, T. Morioka, S. Tanaka, A. Kizu, K. Motoyama, K. Mori, S. Fukumoto, A. Shioi, N. Shimogaito, M. Takeuchi, Y. Yamamoto, H. Yonekura, H. Yamamoto, Y. Nishizawa, Diabetes.55:2245-2255Aug. 2006
  • Development of an ELISA for esRAGE and its application to type 1 diabetic patients., (S. Sakurai), Y. Yamamoto, H. Tamei, H. Matsuki, K.-I. Obata, H. Hui, J. Miura, M. Osawa, Y. Uchigata, Y. Iwamoto, T. Watanabe, H. Yonekura, H. Yamamoto, Diabetes research and clinical practice.73:158-165Aug. 2006
  • Identification of mouse ortholog of endogenous secretory receptor for advanced glycation endproducts: structure, function and expression., (A. Harashima), Y. Yamamoto, C. Cheng, K. Tsuneyama, K.M. Myint, A. Takeuchi, K. Yoshimura, H. Li, T. Watanabe, S. Takasawa, H. Yonekura, H. Okamoto, H. Yamamoto, The Biochemical journal.396:109-115Mar. 2006
  • EAPC2 acts as a negative regulator in Matrigel-driven tubulogenesis of human microvascular endothelial cells, Takayuki Ikeda, Yoshino Yoshitake, Yasuo Yoshitomi, Hidehito Saito-Takatsuji, Yasuhito Ishigaki, Hideto Yonekura, Scientific reports11:19453Sep. 2021
  • Protective Effects of Collagen Tripeptides in Human Aortic Endothelial Cells by Restoring ROS-Induced Transcriptional Repression, Hidehito Saito-Takatsuji, Yasuo Yoshitomi, Yasuhito Ishigaki, Shoko Yamamoto, Noriaki Numata, Yasuo Sakai, Masayoshi Takeuchi, Naohisa Tomosugi, Shogo Katuda, hideto Yonekura, Takayuki Ikeda, Nutrients13:2226Jun. 2021
  • Emerging Role of AP-1 Transcription Factor JunB in Angiogenesis and Vascular Development, Yasuo Yoshitomi, Takayuki Ikeda, Hidehito Saito-Takatsuji, Hideto Yonekura, International Journal of Molecular Sciences22:2804Mar. 2021
  • Role of Decorin in Posterior Capsule Opacification and Eye Lens Development., Shinsuke Shibata, Naoko Shibata, Satoshi Ohtsuka, Yasuo Yoshitomi, Etsuko Kiyokawa, Hideto Yonekura, Dhirendra P. Singh, Hiroshi Sasaki, Eri Kubo, Cells10:863Apr. 2021