Japanese

YONEKURA Hideto

■Faculty	Department of Biochemistry Ⅱ, Division of Innovative Research
■Position	Professor

Researcher Profile & Settings

Research

Overview of research:

1. Mechanisms of regulation of alternative pre-mRNA processing 2. Molecular mechanisms of angiogenesis regulation 3. Identification of genes involved in neuro-vascular interaction 4. Molecular mechanisms of development of diabetic vascular complications

Special Field

General medical chemistry
Functional biochemistry
Functional biochemistry
Pathological medical chemistry

Education

Nagoya University Graduate School Division of Medicine
Nagoya University Faculty of Science

Association Memberships

Nov. 2015- Nov. 2017The Japanease Biochemical Society
1985The Molecular Biology Society of Japan

Academic & Professional Experience

Apr. 1985- Nov. 1990Kissei Pharmaceutical Co., Ltd. Researcher
Nov. 1990- Nov. 1994Tohoku University Assistant professor
Dec. 1994- Mar. 1996Tohoku University Associate professor
Apr. 1996- Mar. 2006Kanazawa University Associate professor
Apr. 2006Kanazawa Medical University Professor

Research Activities

Published Papers

Role of Arginine Methylation in Alternative Polyadenylation of VEGFR-1 (Flt-1) pre-mRNA, Takayuki Ikeda, Hidehito Saito-Takatsuji, Yasuo Yoshitomi, Hideto Yonekura, International Journal of Molecular Sciences, 21:6460, Sep. 2020
Ultraviolet B-induced Otx2 expression in lens epithelial cells promotes epithelial-mesenchymal transition, Yoshitomi Y, Osada H, Satake H, Kojima M, Saito-Takatsuji H, Ikeda T, Yoshitake Y, Ishigaki Y, Kubo E, Sasaki H, Yonekura H, Biology Open, 8:bio035691, Feb. 2019
Effect of Collagen Tripeptide on Atherosclerosis in Healthy Humans., N.Tomosugi, S.Yamamoto, M.Takeuchi, H.Yonekura, Y.Ishigaki, N.Numata, S.Katsuda, Y.Sakai, Journal of atherosclerosis and thrombosis, 24:530-538, May 2017
Effect of Collagen Tripeptide on Atherosclerosis in Healthy Humans, Naohisa Tomosugi, Shoko Yamamoto, Masayoshi Takeuchi, Hideto Yonekura, Yasuhito Ishigaki, Noriaki Numata, Shogo Katsuda, Yasuo Sakai, Journal of Atherosclerosis and Thrombosis, 24:530-538, May 2017
JunB regulates angiogenesis and neurovascular parallel alignment in mouse embryonic skin, Y.Yoshitomi,T.Ikeda,H.Saito,Y.Yoshitake,Y.Ishigaki,T.Hatta,N.Kato,H.Yonekura, Jonal of Cell Science, 130:916-926, Jan. 2017
Regulation of soluble Flt-1(VEGFR-1) production by hnRNP D and protein arginine methylation, T.Ikeda, Y.Yoshitomi, H.Saito, T.Shimasaki, H.Yamaya, T.Kobata, Y.Ishigaki, N.Tomosugi, Y.Yoshitake, H.Yonekura, Molecular and Cellular Biochemistry, 413:155-164, 2016
Melanocortins contribute to sequential differentiation and enucleation of human erythroblasts via melanocortin receptors 1, 2 and 5, E.Simamura, T.Arikawa, T.Ikeda, H.Shimada, H.Shoji, H,Masuta, Y.Nakajima, H.Otani, H.Yonekura, T.Hatta, PLoS One, 10:e0123232-e0123232, 2015
DOI:10.1371/journal.pone.0123232
Osteocytic cell necrosis is caused by a combination of glucocorticoid-induced Dickkopf-1 and hypoxia, S.Ueda, T.Ichiseki, Y.Yoshitomi, H.Yonekura, Y.Ueda, A.Kaneuji, T.Matsumoto, Medical Molecular Morphology, 48:69-75, Jun. 2015
DOI:10.1007/s00795-014-0077-9
Low-molecular weight fractions of Japanese soy sauce act as a RAGE antagonist via inhibition of RAGE trafficking to lipid rafts., (S.Munesue), Y.Yamamoto, R.Urushihara, K.Inomata, H.Saito, S.Motoyoshi, T.Watanabe, H.Yonekura, H.Yamamoto, Food & function., 4:1835-1842, Dec. 2013
Low molecular weight heparin suppresses receptor for advanced glycation end products-mediated expression of malignant phenotype in human fibrosarcoma cells., (A.Takeuchi), Y.Yamamoto, S.Munesue, A.Harashima, T.Watanabe, H.Yonekura, H.Yamamoto, H.Tsuchiya, Cancer science., 104:740-749, Jun. 2013
Identification of a major enzyme for the synthesis and hydrolysis of cyclic ADP-ribose in amphibian cells and evolutional conservation of the enzyme from human to invertebrate, T.Ikeda, S.Takasawa, N.Noguchi, K.Nata, A.Yamauchi, I.Takahashi, T.Yoshikawa, A.Sugawara, H.Yonekura, H.Okamoto, Molecular and cellular biochemistry., 366:69-80, Jul. 2012
Loss of HITS(FAM107B) expression in cancers of multiple organs: tissue microarray analysis, (H.Nakajima), K.Koizumi, T.Tanaka, Y.Ishigaki, Y.Yoshitake, H.Yonekura, T.Sakuma, T.Fukushima, H.Umehara, S.Ueno, T.Minamoto, Y.Motoo, International journal of oncology, 41:1347-1357, May 2012
Endogenous secretory receptor for advanced glycation end-products inhibits amyloid-β1-42 uptake into mouse brain, (T.Sugihara), S.Munesue, Y.Yamamoto, S.Sakurai, N.Akhter, Y.Kitamura, K.Shiba, T.Watanabe, H.Yonekura, Y.Hayashi, J.Hamada, H.Yamamoto, Journal of Alzheimer's disease : JAD, 28:709-720, Feb. 2012
Suppression of a neocortical potassium channel activity by intracellular amyloid-β and its rescue with homer1a, K.Yamamoto, Y.Ueta, L.Wang, R.Yamamoto, N.Inoue, K.Inokuchi, A.Aiba, H.Yonekura, N.Kato, The Journal of neuroscience : the official journal of the Society for Neuroscience, 31:11100-11109, Aug. 2011
Hypoxia down-regulates sFlt-1 (sVEGFR-1) expression in human microvascular endothelial cells by a mechanism involving mRNA alternative processing, T.Ikeda, L.Sun, N.Tsuruoka, Y.Ishigaki, Y.Yoshitomi, Y.Yoshitake, H.Yonekura, The Biochemical journal., 436:399-407, Jun. 2011
Identification of the COL2A1 mutation in patients with type I Stickler syndrome using RNA from freshly isolated peripheral white blood cells, H.Yaguchi, T.Ikeda, H.Osada, Y.Yoshitake, H.Sasaki, H.Yonekura, Genetic testing and molecular biomarkers., 15:231-237, Apr. 2011
Ultraviolet B-induced expression of amphiregulin and growth differentiation factor 15 in human lens epithelial cells, H.Osada, Y.Yoshitake, T.Ikeda, Y.Ishigaki, T.Takata, N.Tomosugi, H.Sasaki, H.Yonekura, Molecular vision, 17:159-169, Jan. 2011
Septic shock is associated with receptor for advanced glycation end products ligation of LPS, (Y.Yamamoto), A.Harashima, H.Saito, K.Tsuneyama, S.Munesue, S.Motoyoshi, D.Han, T.Watanabe, M.Asano, S.Takasawa, H.Okamoto, S.Shimura, T.Karasawa, H.Yonekura, H.Yamamoto, Journal of immunology (Baltimore, Md. : 1950), 186:3248-3257, 2011
Regulation of alternative splicing of the receptor for advanced glycation endproducts (RAGE) through G-rich cis-elements and heterogenous nuclear ribonucleoprotein H, (K.Ohe), T.Watanabe, S.Harada, S.Munesue, Y.Yamamoto, H.Yonekura, H.Yamamoto, Journal of biochemistry., 147:651-659, May 2010
Induction of HITS, a newly identified family with sequence similarity 107 protein (FAM107B), in cancer cells by heat shock stimulation, H.Nakajima, Y.Ishigaki, QI-S.Xia, T.Ikeda, Y.Yoshitake, H.Yonekura, T.Nojima, T.Tanaka, H.Umehara, N.Tomosugi, T.Takata, T.Shimasaki, N.Nakaya, I.Sato, K.Kawakami, K.Koizumi, T.Minamoto, Y.Motoo, International journal of oncology, 37:583-593, 2010
Solution structure of the variable-type domain of the receptor for advanced glycation end products:new insight into AGE-RAGE interaction, (S.Matsumoto), T.Yoshida, H.Murata, S.Harada, N.Fujita, S.Nakamura, Y.Yamamoto, T.Watanabe, H.Yonekura, H.Yamamoto, T.Ohkubo, Y.Kobayashi, Biochemistry., 47:12299-12311, Nov. 2008
Reduced expression of endogenous secretory receptor for advanced glycation endproducts in hippocampal neurons of Alzheimer's disease brains, (I.Nozaki), T.Watanabe, M.Kawaguchi, H.Akatsu, K.Tsuneyama, Y.Yamamoto, K.Ohe, H.Yonekura, M.Yamada, H.Yamamoto, Archives of histology and cytology., 70:279-290, Dec. 2007
Promotion by collagen tripeptide of Type I collagen gene expression in human osteoblastic cells and fracture healing of rat femur, N.Tsuruoka, R.Yamato, Y.Sakai, Y.Yoshitake, H.Yonekura, Bioscience, biotechnology, and biochemistry, 71:2680-2687, Nov. 2007
De-N-glycosylation or G82S mutation of RAGE sensitizes its interaction with advanced glycation endproducts, (M.Osawa), Y.Yamamoto, S.Munesue, N.Murakami, S.Sakurai, T.Watanabe, H.Yonekura, Y.Uchigata, Y.Iwamoto, H.Yamamoto, Biochimica et biophysica acta-molecular and cell biology of lipids, 1770:1468-1474, Oct. 2007
Short-chain aldehyde-derived ligands for RAGE and their actions on endothelial cells, (Y.Yamamoto), H.Yonekura, T.Watanabe, S.Sakurai, H.Li, A.Harashima, KM.Myint, M.Osawa, A.Takeuchi, M.Takeuchi, H.Yamamoto, Diabetes research and clinical practice., 77 (Suppl 1):S30-40, Jun. 2007
Endogenous secretory receptor for advanced glycation endproducts as a novel prognostic marker in chondrosarcoma, (A.Takeuchi), Y.Yamamoto, K.Tsuneyama, C.Cheng, H.Yonekura, T.Watanabe, K.Shimizu, K.Tomita, H.Yamamoto, H.Tsuchiya, Cancer, 109:2532-2540, Jun. 2007
Endogenous secretory receptor for advanced glycation endproducts levels are correlated with serum pentosidine and CML in patients with type 1 diabetes., (Miura, J.), Yamamoto, Y., Osawa, M., Watanabe, T., Yonekura, H., Uchigata, Y., Yamamoto, H., Iwamoto, Y., Arteriosclerosis, thrombosis, and vascular biology., 27: 253-254, Jan. 2007
RAGE in diabetic nephropathy, (H.Yamamoto), T.Watanabe, Y.Yamamoto, H.Yonekura, S.Munesue, A.Harashima, K.Ooe, S.Hossain, H.Saito, N.Murakami, Current molecular medicine, 7:752-757, 2007
Assaying soluble forms of receptor for advanced glycation end products. (Response), (Y.Yamamoto), J.Miura, S.Sakurai, T.Watanabe, H.Yonekura, H.Tamei, H.Matsuki, K.Obata, Y.Uchigata, Y. Iwamoto, H.Koyama, H.Yamamoto, Arteriosclerosis, thrombosis, and vascular biology., 27:e33-34, 2007
RAGE control of diabetic nephropathy in a mouse model: effects of RAGE gene disruption and administration of low-molecular weight heparin, (K.M.Myint), Y.Yamamoto, T.Doi, I.Kato, A.Harashima, H.Yonekura, T. Watanabe, H.Shinohara, M.Takeuchi, K. Tsuneyama, N.Hashimoto, M.Asano, S.Takasawa, H. Okamoto, H.Yamamoto, Diabetes., 55:2510-2522, Sep. 2006
Receptor for advanced glycation endproducts is involved in impaired angiogenic response in diabetes., (T. Shoji), H. Koyama, T. Morioka, S. Tanaka, A. Kizu, K. Motoyama, K. Mori, S. Fukumoto, A. Shioi, N. Shimogaito, M. Takeuchi, Y. Yamamoto, H. Yonekura, H. Yamamoto, Y. Nishizawa, Diabetes., 55:2245-2255, Aug. 2006
Development of an ELISA for esRAGE and its application to type 1 diabetic patients., (S. Sakurai), Y. Yamamoto, H. Tamei, H. Matsuki, K.-I. Obata, H. Hui, J. Miura, M. Osawa, Y. Uchigata, Y. Iwamoto, T. Watanabe, H. Yonekura, H. Yamamoto, Diabetes research and clinical practice., 73:158-165, Aug. 2006
Identification of mouse ortholog of endogenous secretory receptor for advanced glycation endproducts: structure, function and expression., (A. Harashima), Y. Yamamoto, C. Cheng, K. Tsuneyama, K.M. Myint, A. Takeuchi, K. Yoshimura, H. Li, T. Watanabe, S. Takasawa, H. Yonekura, H. Okamoto, H. Yamamoto, The Biochemical journal., 396:109-115, Mar. 2006
EAPC2 acts as a negative regulator in Matrigel-driven tubulogenesis of human microvascular endothelial cells, Takayuki Ikeda, Yoshino Yoshitake, Yasuo Yoshitomi, Hidehito Saito-Takatsuji, Yasuhito Ishigaki, Hideto Yonekura, Scientific reports, 11:19453, Sep. 2021
Protective Effects of Collagen Tripeptides in Human Aortic Endothelial Cells by Restoring ROS-Induced Transcriptional Repression, Hidehito Saito-Takatsuji, Yasuo Yoshitomi, Yasuhito Ishigaki, Shoko Yamamoto, Noriaki Numata, Yasuo Sakai, Masayoshi Takeuchi, Naohisa Tomosugi, Shogo Katuda, hideto Yonekura, Takayuki Ikeda, Nutrients, 13:2226, Jun. 2021
Emerging Role of AP-1 Transcription Factor JunB in Angiogenesis and Vascular Development, Yasuo Yoshitomi, Takayuki Ikeda, Hidehito Saito-Takatsuji, Hideto Yonekura, International Journal of Molecular Sciences, 22:2804, Mar. 2021
Role of Decorin in Posterior Capsule Opacification and Eye Lens Development., Shinsuke Shibata, Naoko Shibata, Satoshi Ohtsuka, Yasuo Yoshitomi, Etsuko Kiyokawa, Hideto Yonekura, Dhirendra P. Singh, Hiroshi Sasaki, Eri Kubo, Cells, 10:863, Apr. 2021
Transthyretin Is Commonly Upregulated in the Hippocampus of Two Stress-Induced Depression Mouse Models., Hidehito Saito-Takatsuji, Yasuo Yoshitomi, Ryo Yamamoto, Takafumi Furuyama, Yasuhito Ishigaki, Nobuo Kato, Hideto Yonekura, Takayuki Ikeda, International Journal of Molecular Sciences, 24:3736, Feb. 2023

Note: Performance information for the past 1-2 years may be revised at a later date due to inspections conducted by the committee from July to September every year.