SHIMASAKI Miyako

Researcher Profile & Settings

Research

Overview of research:
In recent years, we have focused on in vivo and in vitro research toward the clinical application of regenerative medicine using bone marrow-derived mesenchymal stem cells. We are actively conducting research on steroid-induced osteonecrosis and osteoarthritis, and in addition to conventional morphological and gene/molecular expression analysis using human materials, we are conducting research on the latest molecules using animal experimental models and cultured cells. We aim to "integrate pathological morphology and molecular pathology" by introducing pathological methods to analyze the functions of genes and molecules in vitro and in vivo.

Special Field

• bone marrow-derived mesenchymal stem cells

Research Activities

Published Papers

• Glioblastoma/high-grade glioma with a primitive neuronal component including rhabdoid differentiation that was difficult to diagnose: A case report, Motona Kumagai, Sho Takata, Takuya Watanabe, Akihiro Shioya, Jia Han, Miyako Shimasaki, Yoshimichi Ueda, Yasuhiko Hayashi, Sohsuke Yamada, 251:154830, Nov. 2023
• Inhibitory effect of taurine on rotator cuff degeneration via mitochondrial protection, Shusuke Ueda, Toru Ichiseki, Miyako Shimasaki, Hiroaki Hirata, Norio Kawahara, Yoshimichi Ueda, American Journal of Translational Research, 14:6286-6294, Sep. 2022
• Prognostic Impact of Sphingosine Kinase 1 in Nonsmall Cell Lung Cancer., Motono N, Ueda Y, Shimasaki M, Iwai S, Iijima Y, Usuda K, Uramoto H., Clinical Pathology, 14:1970430, Sep. 2021
  DOI:10.1177/2632010X20988531
• Glucocorticoid-induced osteocytic cell death in a hypoxic environment is associated with necroptosis, Shusuke Ueda, Toru Ichiseki, Miyako Shimasaki, Hiroaki Hirata, Norio Kawahara, Yoshimichi Ueda, BioChem, 1:98-106, Aug. 2021
  DOI:10.3390/biochem1020009
• Resistance of bone marrow mesenchymal stem cells in a stressed environment - Comparison with osteocyte cells, Miyako Shimasaki, Shusuke Ueda, Toru Ichiseki, Hiroaki Hirata, Norio Kawahara, Yoshimichi Ueda, International Journal of Medical Sciences, 18:1375-1381, Jan. 2021
  DOI:10.7150/ijms.52104
• Taurine inhibits glucocorticoid-induced bone mitochondrial injury, preventing osteonecrosis in rabbits and cultured osteocytes, Hiroaki Hirata, Shusuke Ueda, Toru Ichiseki, Miyako Shimasaki, Yoshimichi Ueda, Ayumi Kaneuji, Norio Kawahara, International journal of molecular sciences, 21:6892, Sep. 2020
  DOI:10.3390/ijms21186892
• Mitochondrial transcription factor A added to osteocytes in a stressed environment has a cytoprotective effect, Shusuke Ueda, Miyako Shimasaki, Toru Ichiseki, Hiroaki Hirata, Norio kawahara, Yoshimichi Ueda, International journal of medical sciences, 17:1293-1299, May 2020
  DOI:10.7150/ijms.45335
• Reverse shoulder arthroplasty for primary synovial osteochondromatosis of the shoulder with massive rotator cuff tear and marked degenerative arthropathy, Toru.Ichiseki, Shusuke.Ueda, Daisuke.Souma, Miyako.Shimasaki, Yoshimichi.Ueda, Norio.Kawahara, Journal of Clinical Medicine, 7:189, Jul. 2018
  DOI:10.3390/jcm7080189
• Expression and Prognostic Impact of VEGF, CD31 and alpha SMA in Resected Primary Lung Cancers, Usuda, Katsuo;Iwai, Syun;Funasaki, Aika;Sekimura, Atsushi;Motono, Nozomu;Ueda, Yoshimiti;Shimazaki, Miyako;Uramoto, Hidetaka, ANTICANCER RESEARCH, 38:4057-4063, Jul. 2018
  DOI:10.21873/anticanres.12695
• Expression of Sphingosine Kinase-1 Is Associated with Invasiveness and Poor Prognosis of Oral Squamous Cell Carcinoma, Koichiro.Kato, Miyako.Shimasaki, Takao.Kato, Natsuki.Segami, Yoshimichi.Ueda, Anticancer Research, 38:1361-1368, Mar. 2018
  DOI:10.21873/anticanres.12359
• Intraarticularly-injected mesenchymal stem cells stimulate anti-inflammatory molecules and inhibit pain related protein and chondrolytic enzymes in a monoiodoacetate-induced rat arthritis model, Toru.Ichiseki, Miyako.Shimasaki, Yoshimichi.Ueda, Shusuke.Ueda, Masanobu.Tsuchiya, Daisuke.Souma, Ayumi.Kaneuji, Norio.Kawahara, International Journal of Molecular Sciences, 19:203, Jan. 2018
  DOI:10.3390/ijms19010203
• Mitochondrial stress and redox failure in steroid-associated osteonecrosis, Masanobu.Tsuchiya, Toru.Ichiseki, Shusuke.Ueda, Yoshimichi.Ueda, Miyako.Shimazaki, Ayumi.Kaneuji, Norio.Kawahara, International Journal of Medical Sciences, 15:205-209, Jan. 2018
  DOI:10.7150/ijms.22525
• Aquaporin-1 and -5 are involved in the invasion and proliferation of soft tissue sarcomas, Shimasaki Miyako;Kanazawa Yoshimitsu;Sato Katsuaki;Tsuchiya Hiroyuki;Ueda Yoshimichi, Pathology-Research and Practice, 214:80-88, 2018
  DOI:10.1016/j.prp.2017.11.006
• Prevention of glucocorticoid-associated osteonecrosis by intravenous administration of mesenchymal stem cells in a rabbit model, Shusuke.Ueda, Miyako.Shimasaki, Toru.Ichiseki, Yoshimichi.Ueda, Masanobu.Tsuchiya, Ayumi.Kaneuji, Norio.Kawahara, BMC musculoskeletal disorders, 18:480, Nov. 2017
  DOI:10.1186/s12891-017-1837-1
• High FDG uptake on PET is associated with negative cell-to-cell adhesion molecule E-cadherin expression in lung adenocarcinoma., (Kotaro.Higashi), Yoshimichi.Ueda, Miyako.Shimasaki,　Yasuhito.Ishigaki , Yuka.Nakamura, Managu.Oguchi, Tsutomu.Takegami, Naoto.Watanabe., Annals of nuclear medicine, 31:590-595, 2017
• Correlation of HIF-1α/HIF-2α expression with FDG uptake in lung adenocarcinoma., (K.Higashi), T.Yamagishi, Y.Ueda, Y.Ishigaki, M.Shimasaki, Y.Nakamura, M.Oguchi, T.Takegami, M.Sagawa, H.Tonami, Annals of nuclear medicine, 30:708-715, 2016
• Relationship of aquaporin 1,3,and 5 expression in lung cancer cells to cellular differentiation, invasive growth, and metastasis potential, Y.Machida, Y.Ueda, M.Shimasaki, K.Sato, M.Sagawa, S.Katsuda, T.Sakuma, Human pathology., 42:669-678, Jan. 2011
• Aquaporin as a novel player in cancer cell the invasion of cancer cells, Y.Ueda, M.Shimasaki, Y.Machida, Y.Takahara, Y.Himi, Y.Ishigaki, K.Sato, T.Sakuma, H.Toga, S.Kawakami, S.Katsuda, 35:55-60, Aug. 2010
• Endogenous catecholamine stimulates alveolar fluid clearance in rats with acute pancreatitis, J.Xu, Z.Wang, G.Ma, M.Sagawa, M.Shimazaki, Y.Ueda, T.Sakuma, Respirology (Carlton, Vic.), 14:195-202, Apr. 2009
• Proliferetive and differentiative effects of basic fibroblast grouwth factor(bFGF) on perichondium of rabbit's ear, N.Koizumi, T.Miyanaga, S.Kawakami, M.Shimasaki, Y.Ueda, 増11：14-20, Feb. 2009
• Recent advance in the pathology of lung cancer, Y.Ueda, M.Shimasaki, K.Higashi, G.Guo, K.Sato, M.Sagawa, T.Sakuma, S.Katsuda, 33:21-30, Jun. 2008
• Identification of novel genes involved in the synergistic antitumor effect of caffeine in osteosarcoma cells using cDNA macroarray, (S. Ii), Y. Ueda, M. Shimasaki, S. Katsuda, K. Takazawa, Y. Kanazawa, K. Tomita, H. Tsuchiya, Anticancer research., 28:645-653, 2008
• Down-regulation of plakoglobin in soft tissue sarcoma is associated with a higher risk of pulmonary metastasis, (Y. Kanazawa), Y. Ueda, M. Shimasaki, S. Katsuda, N. Yamamoto, K. Tomita, H. Tsuchiya, Anticancer research., 28:655-664, 2008
• Chronic pulmonary artery occlusion increases alveolar fluid clearance in rats, Z.Wang, J.Xu, G.Ma, M.Sagawa, M.Shimazaki, Y.Ueda, T.Sakuma, The Journal of thoracic and cardiovascular surgery., 134:1213-1219, Nov. 2007
• Plakoglobin, a novel tumor supressing protein, to control metastasis of soft tissue sarcomas, Y.Ueda, Y.Kanazawa, M.Shimazaki, K.Sato, G.Ming, D.Jiang, H.Tsuchiya, K.Tomita, S.Katsuda, 32:1-7, Jun. 2007
• Efficacy of rectal systemic administration of mesenchymal stem cells to injury sites via the CXCL12/CXCR4 axis to promote regeneration in a rabbit skeletal muscle injury model, Toru Ichiseki, Miyako Shimasaki, Shusuke Ueda, Hiroaki Hirata, Daisuke Souma, Norio Kawahara and Yoshimichi Ueda, Cells, 12:1729, Jun. 2023
  DOI:10.3390/cells12131729
• The Possibility of IPC to Prevent Ischemic-Reperfusion Injury in Skeletal Muscle in a Rat, Takanori Morikawa, Miyako Shimasaki, Toru Ichiseki, Shusuke Ueda, Yoshimichi Ueda, Kan Takahashi, Journal of Clinical Medicine, 12:1501, Feb. 2023
• Mesenchymal Stem Cells Preconditioned with Hypoxia and Dexamethasone Promote Osteoblast Differentiation Under Stress Conditions, Miyako Shimasaki, Toru Ichiseki, Shusuke Ueda, Hiroaki Hirata, Norio Kawahara, Yoshimichi Ueda, International Journal of Medical Sciences, 21:1511-1517, May 2024
  DOI:10.7150/ijms91222
• Effect of high-dose vitamin C on tendon cell degeneration —An In vitro study, Shusuke Ueda, Toru Ichiseki, Miyako Shimasaki, Daisuke Soma, Masaru Sakurai, Ayumi Kaneuji, Norio Kawahara, International Journal of Molecular Sciences, 25:13358, Dec. 2024
  DOI:10.3390/ijms252413358
• Celecoxib Combined with Tocilizumab Has Anti-Inflammatory Effects and Promotes the Recovery of Damaged Cartilage via the Nrf2/HO-1 Pathway In Vitro, Miyako Shimasaki, Shusuke Ueda, Masaru Sakurai, Norio Kawahara, Yoshimichi Ueda, Toru Ichiseki, Biomolecules, 14:1636, Dec. 2024
  DOI:10.3390/biom14121636