Japanese

OTSUKA Toshimi

■Faculty	Department of Gastroenterology
■Position	Associate Professor

Researcher Profile & Settings

Research

Overview of research:

Clinico-pathological study of nonalcoholic steatohepatitis

Degree

Ph.D in Medicine

Research Activities

Published Papers

Durvalumab-induced Immune-related Hepatitis in a Patient with Non-small Cell Lung Cancer, Nakamura Masakatsu, Otsuka Toshimi, Hayashi Ranji, Horita Tomoe, Ota Masafumi, Sakurai Naoko, Takano Hikaru, Hayashi Tasuku, Kumagai Motona, Yamada Sohsuke, Arisawa Tomiyasu, Internal Medicine, 59:2711-2717, Nov. 2020
DOI:10.2169/internalmedicine.4699-20
Influence of MIF polymorphisms on CpG island hyper-methylation of CDKN2A in the patients with ulcerative colitis, Naoko Sakurai, Tomoyuki Shibata, Masakatsu Nakamura, Hikaru Takano, Tasuku Hayashi, Masafumi Ota, Tomoe Nomura-Horita, Ranji Hayashi, Takeo Shimasaki, Toshimi Ostuka, Tomomitsu Tahara, Tomiyasu Arisawa, BMC Medical Genetics, 21:201, Oct. 2020
Effect of DNMT3A polymorphisms on CpG island hypermethylation in gastric mucosa, Takano Hikaru, Shibata Tomoyuki, Nakamura Masakatsu, Sakurai Naoko, Hayashi Tasuku, Ota Masafumi, Nomura-Horita Tomoe, Hayashi Ranji, Shimasaki Takeo, Otsuka Toshimi, Tahara Tomomitsu, Arisawa Tomiyasu, BMC Medical Genetics, 21:205, Oct. 2020
DOI:10.1186/s12881-020-01142-7
A Case of Severe Duodenitis in an Adult Patient with Hyper IgESyndrome, Tomoe Nomura-Horita, Tasuku Hayashi, Toshimi Otsuka, Naoko Sakurai, Hikaru Takano, Masafumi Ota, Ranji Hayashi, Takeo Shimasaki, Masakatsu Nakamura, Sohsuke Yamada, Takashi Mochizuki, Tomiyasu Arisawa, Japanese Journal of Gastroenterology and Hepatology, 4:1-3, Jul. 2020
Polymorphism rs7521584 in miR-429 is associated with the severity of atrophic gastritis in patients with Helicobacter pylori infection, Toshimi Otsuka,Tomomitu Tahara,Masakatsu Nakamura, Wu Ging,Masafumi Ota, Tomoe Nomura, Ranji Hayashi, Takeo Shimasaki, Tomoyuki Shibata, Tomiyasi Arisawa, Molecular Medicine Reports, 18:2381-2386, Aug. 2018
Association between receptor interacting serine/threonine kinase 2 polymorphisms and gastric cancer susceptibility, Masafumi Ota,Tomomitu Tahara, Toshimi Otsuka, Wu Jing,Tomoe Nomura,Ranji Hayashi,Takeo Shimasaki,Masakatsu Nakamura,Tomoyuki Shibata,Tomoyasu Arisawa, ONCOLOGY LETTERS, 15:3772-3778, Mar. 2018
Genetic polymorphisms of MAFK, encoding a small Maf protein, are associated with susceptibility to ulcerative colitis in Japan, Arisawa, Tomiyasu;Nakamura, Masakatsu;Otsuka, Toshimi;Jing, Wu;Sakurai, Naoko;Takano, Hikaru;Hayashi, Tasuku;Ota, Masafumi;Nomura, Tomoe;Hayashi, Ranji;Shimasaki, Takeo;Tahara, Tomomitsu;Shibata, Tomoyuki, WORLD JOURNAL OF GASTROENTEROLOGY, 23:5364-5370, Aug. 2017
DOI:10.3748/wjg.v23.i29.5364
The effect of short-term proton pump inhibitor plus anti-ulcer drug on the healing of endoscopic submucosal dissection-derived artificial ulcer: A randomized controlled trial, M.Nakamura, T.Tahara, H.Shiroeda, K.Matsunaga, T.Otsuka, J.Yonemura, T.Shibata, T.Arisawa, Hepato-Gastroenterology, 62:219-224, 2015
DOI:10.5754/hge13631
The *1244A>G polymorphism of MyD88(rs7744)is closely associated with susceptibility to ulcerative colitis, K.Matsunaga, T.Tahara, H.Shiroeda, T.Otsuka, M.Nakamura, T.Shimasaki, N.Toshikuni, N.Kawada, T.Shibata, T.Arisawa, Molecular medicine reports., 9:28-32, Jan. 2014
A case of IgG4-related disease complicated by duodenal bulbitis with IgG4-positive plasma cell infiltration, K.Matsunaga, R.Hayashi, T.Otsuka, D.Kaida, N.Ueda, T.Kosaka, T.Arisawa, 46:E408-E410, 2014
Influence of HRH2 promoter polymorphism on aberrant DNA methylation of DAPK and CDH1 in the gastric epithelium., T.Nomura, T.Tahara, H.Shiroeda, T.Minato, Y.Matsue, R.Hayashi, K.Matsunaga, T.Otsuka, M.Nakamura, N.Toshikuni, T.Shibata, T.Arisawa, BMC gastroenterology, 13:1471-1479, 2013
Genetic polymorphisms of SCN10A are associated with functional dyspepsia in Japanese subjects., T.Arisawa, T.Tahara, H. Shiroeda, T.Minato, Y.Matsue, T.Saito, T.Fukuyama, T.Otsuka, A.Fukumura, M.Nakamura, T.Shibata, Journal of gastroenterology., 48:73-80, 2013
Functional promoter polymorphisms of NFKB1 influence susceptibility to the diffuse type of gastric cancer., T.Arisawa, T.Tahara, H.Shiroeda, K.Yamada, T.Nomura, H.Yamada, R.Hayashi, K.Matsunaga, T.Otsuka, M.Nakamura, T.Shimasaki, N.Toshikuni, N.Kawada, T.Shibata, Oncology reports., 30:3013-3019, 2013
Association between functional promoter polymorphisms of macrophage migration inhibitory factor(MIF)gene and ulcerative colitis in Japan, H.Shiroeda, T.Tahara, M.Nakamura, T.Shibata, T.Nomura, H.Yamada, R.Hayashi, T.Saito, M.Yamada, T.Fukuyama, T.Otsuka, H.Yano, K.Ozaki, M.Tsuchishima, M.Tsutsumi, T.Arisawa, Cytokine., 51:173-177, May 2010
A case ob jejunal GIST diagnosed by double-baloon endoscopy, S.Siroeda, H.Siroeda, T.Ootsuka, M.Yamada, T.Fukuyama, T.Saito, R.Hayashi, T.Nomura, H.Yano, K.Ozaki, T.Arisawa, M.Yokoi, T.Kosaka, M.Tsutsumi, ENDOSCOPIC FORUM for digestive disease, 26:44-49, 2010
Functional promoter polymorphisms of macrophage migration inhibitory factor in peptic ulcer diseases, H.Shiroeda, T.Tahara, M.Nakamura, T.Shibata, H.Yamada, T.Nomura, R.Hayashi, T.saito, T.Fukuyama, T.Otsuka, H.Yano, K.Ozaki, M.Tsuchishima, M.Tsutsumi, T.Arisawa, International journal of molecular medicine, 26:707-711, 2010
MAFK Polymorphisms Located in 3'-UTR are Associated with Severity of Atrophy and CDKN2A Methylation Status in the Gastric Mucosa, Tasuku Hayashi, Tomoyuki Shibata, Masakatsu Nakamura, Naoko Sakurai, Hikaru Takano, Masafumi Ota, Tomoe Nomura-Horita, Ranji Hayashi, Takeo Shimasaki, Toshimi Ostuka, Tomomitsu Tahara, Tomiyasu Arisawa, GENETIC TESTING AND MOLECULAR BIOMARKERS, 25:255-262, 2021
Dissection and removal of bile duct plastic stents penetrating the duodenal papilla: report of three rare cases, Masakatsu Nakamura, Toshimi Otsuka, Ranji Hayashi, Tomoe Horita, Masafumi Ota, Naoko Sakurai, Hikaru Takano, Tasuku Hayashi, Seiko Miura, Nobuhiko Ueda, Hiroyuki Takamura, Tomiyasu Arisawa, Clinical Journal of Gastroenterology, 14:1255-1262, Aug. 2021
Pembrolizumab-induced Eosinophilic Gastrointestinal Disorders, Masakatsu Nakamura, Toshimi Otsuka, Motona Kumagai, and Tomiyasu Arisawa, Internal Medicine, 61:267-269, Jan. 2022
Review of Biliary Drainage in the Management for Preoperative and Unresectable Malignant Distal Biliary Obstructions, Tsuyoshi Mukai, Hiroaki Kunou, Rika Kobayashi, Junji Kamai, Sadafumi Azukisawa, Ken Kawaura, Hidekazu Kitakata, Tasuku Hayashi, Hikaru Takano, Naoko Sakurai, Ranji Hayashi, Toshimi Otsuka, Tohru Ito, 47:7-12, Jun. 2022

Note: Performance information for the past 1-2 years may be revised at a later date due to inspections conducted by the committee from July to September every year.