KATO Nobuo

FacultyDepartment of Physiology Ⅰ

Researcher Profile & Settings



    Overview of research:
    Intracellular calcium is a versatile messenger involved in numerous intracellular processes. However, in particular cellular contexts, definite signals are adequately carried by calcium ions. How such context-dependent choice of adequate signals is achieved is studied by using two experimental paradigms in the neocortex: synaptic plasticiry and regulation of excitability.


  • Ph.D in Medicine

Research Activities

Published Papers

  • Induction of memory deficit in mice with chronic exposure to cerebrospinal fluid from patients with Anti-N-Methyl-D-Aspartate receptor encephalitis, Y.Li, K.Tanaka, L.Wang, Y.Ishigaki, N.Kato, The Tohoku Journal of Experimental Medicine237:329-338Nov. 2015
  • Improvement of spatial learning by facilitating large-conductance calcium-activated potassium channel with transcranial magnetic stimulation in Alzheimer's disease model mice, F.Wang, Y.Zhang, L.Wang, P.Sun, X.Luo, Y.Ishigaki, T.Sugai, R.Yamamoto, N.Kato, Neuropharmacology97:210-219Jun. 2015
  • Homer1a-dependent recovery from depression-like behavior by photic stimulation in mice, P Sun, Q Zhang, Y Zhang, F Wang, R Chen, R Yamamoto, N Kato, Physiology & Behavior147:334-341Mar. 2015
  • Homer1a disruption increases vulnerability to predictable subtle stress normally sub-threshold for behavioral changes, Y.Shui, L.Wang, X.Luo, O.Uchiumi, R.Yamamoto, T.Sugai, N.Kato, Brain Research.1605:70-75Feb. 2015
  • Expression of hyaluronidase-4 in a rat spinal cord hemisection model, Y.Tachi, T.Okuda, N.Kawahara, N.Kato, Y.Ishigaki, T.Matsumoto, Asian Spine Journal9:7-13Feb. 2015
  • Biphasic modulation by mGlu5 receptors of TRPV1-mediated intracellular calcium elevation in sensory neurons contributes to heat sensitivity., T.Masuoka, T.Nakamura, M.Kudo, J.Yoshida, Y.Takaoka, N.Kato, T.Ishibashi, N.Imaizumi, M.Nishio, British Journal of Pharmacology172:1020-1033Feb. 2015
  • Fear conditioning suppresses large-conductance calcium-activated potassium channels in lateral amygdala neurons., P.Sun, Q.Zhang, Y.Zhang, F.Wang, L.Wang, R.Yamamoto, T.Sugai, N.Kato, Physiology & Behavior138:279-284Jan. 2015
  • Cognitive recovery by chronic activation of the large-conductance calcium-activated potassium channel in a mouse model of Alzheimer's disease, L.Wang, H.Kang, Y.Li, Y.Shui, R.Yamamoto, T.Sugai, N.Kato, Neuropharmacology92:8-15Jan. 2015
  • Cognitive improvement by photic stimulation in a mouse model of Alzheimer's disease, Y.Zhang, F.Wang, X.Luo, L.Wang, P.Sun, M.Wang, Y.Jiang, J.Zou, O.Uchiumi, R.Yamamoto, T.Sugai, K.Yamamoto, N.Kato, Current Alzheimer Research12:860-8692015
  • Serotonin induces depolarization in lateral amygdala neurons by activation of TRPC-like current and inhibition of GIRK current depending on 5-HT2C receptor, R.Yamamoto; N.Hatano; T.Sugai;N.Kato, Neuropharmacology82:49-58Mar. 2014
  • Enhancement of oscillatory activity in the endopiriform nucleus of rats raised under abnormal oral conditions., (H.Yoshimura), M.Hasumoto, T.Sugai, N.Segami, N.Kato, Neurosci Lett.561:162-165Feb. 2014
  • Age-dependent emergence of caffeine-assisted voltage oscillations in the endopiriform nucleus of rats., H.Yoshimura, T.Sugai, T.Hasegawa, C.Yao, T.Akamatsu, N.Kato, Neurosci Res.76:16-21May. 2013
  • Role of the lateral habenula in shaping context-dependent locomotor activity during cognitive tasks., Z-D Wang, L Wang, R.Yamamoto, T.Sugai, N.Kato, Neuroreport.24:276-280Jan. 2013
  • Cardiac BDNF/TrkB signaling can be induced by calorie restriction with improved physical activity in obese mice., T.Kanda, R.Chen, T.Mizuno, D.Sakamoto, D.Usuda, M.Mori, M.Takahashi, N.Kato, H.Sumino, The Internet Journal of Cardiovascular Research82013
  • Multimodal cross-talk of olfactory and gustatory information in the endopiriform nucleus in rats, T.Sugai, R.Yamamoto, H.Yoshimura, N.Kato, Chemical senses.37:681-688Oct. 2012
  • Suppression of synaptic plasticity by cerebrospinal fluid from anti-NMDA receptor encephalitis patients, Q.Zhang, K.Tanaka, P.Sun, M.Nakata, R.Yamamoto, K.Sakimura, M.Matsui, N.Kato, Neurobiol Dis.45:610-615Jan. 2012
  • Intraneuronally injected amyloid beta inhibits long-term potentiation in rat hippocampal slices, I.Nomura, H.Takechi, N.Kato, J Neurophysiol.107:2526-25312012
  • A serotonergic discrimination favoring synaptic inputs that accompany robust spike firing in lateral amygdala neurons, R.Yamamoto, Y.Ueta, T.Sugai, N.Kato, Neuroscience.220:119-1302012
  • Increase in cortical pyramidal cell excitability accompanies depression-like behavior in mice: a transcranial magnetic stimulation study, P.Sun, F-R.Wang, L.Wang, Yu.Zhang, R.Yamamoto, T.Sugai, Q.Zhang, Z-D.Wang, N.Kato, J Neurosci.31:16464-16472Nov. 2011
  • Influences of audio-visual environments on feelings of deliciousness during having sweet foods: an electroencephalogram frequency analysis study, H.Yoshimura, M.Honjyo, T.Sugai, M.Kawabe, K.Kaneyama, N.Segami, N.Kato, Nutritional Neurosci.14:210-215Sep. 2011
  • Suppression of a neocortical potassium channel activity by intracellular amyloid-β and its rescue with homer1a, K.Yamamoto, Y.Ueta, L.Wang, R.Yamamoto, N.Inoue, K.Inokuchi, A.Aiba, H.Yonekura, N.Kato, J Neurosci.31:11100-11109Aug. 2011
  • Correlation between stimulation strength and onset time of signal traveling within the neocortical neural circuits under caffeine application, H.Yoshimura, M.Honjyo, T.Sugai, K.Kaneyama, N.Segami, N.Kato, Neurosci Res.70:370-375Aug. 2011
  • Evaluations of dementia by EEG frequency analysis and psychological examination, H.Yoshimura, S.Morimoto, M.Okuro, N.Segami, N.Kato, J Physiol Sci : JPS60:383-388Sep. 2010
  • Application of caffeine reveals input frequency-dependent determination of signal-traveling routes between primary and secondary visual cortices in rats, H.Yoshimura, T.Sugai, M.Honjo, K.Kaneyama, N.Segami, N.Kato, Neurosci Res.66:30-36Oct. 2009
  • Neurophysiological mechanisms of electroconvulsive therapy for depression., N.Kato, Neurosci Res.64:3-11May. 2009
  • Functional connections between olfactory and gustatory information via the endopiriform nucleus in the rat., T.Sugai, R.Yamamoto, H.Yoshimura, N.Kato15:345-346Dec. 2008
  • Multiple tooth-losses during development suppress age-dependent emergence of oscillatory neural activities in the oral somatosensory cortex., H.Yoshimura, M.Honjo, Y.Mashiyama, K.kaneyama, N.Segami, J.Sato, T.Sugai, N.kato, N.Onoda, Brain Res.1224:37-42Aug. 2008
  • Homer 1a suppresses neocortex long-term depression in a cortical layer-specific manner., Y.Ueta, R.Yamamoto, S.Sugiura, K.Inokuchi, N.Kato, J Neurophysiol.99:950-9572008
  • Signal propagation between the piriform cortex and the endopiriform nucleus in the rat horizontal slice preparation., T.Sugai, R.Yamamoto, H.Yoshimura, N.Kato14:521-522Dec. 2007
  • Dopamine induces a slow afterdepolarization in lateral amygdale neurons., R.Yamamoto, Y.Ueta, N.Kato, J Neurophysiol.98:984-992Aug. 2007
  • Autocorrelogram sorting: A novel method for evaluating negative-feedback regulation of spike firing., (M.Murata), N.Kato, Brain Res.1133:27-33Feb. 2007
  • Component-dependent urine responses in the rat accessory olfactory bulb, T.Sugai, H.Yoshimura, N.Kato, N.Onoda, Neuroreport.17:1663-1667Nov. 2006
  • Blocking L-type calcium channels enhances long-term depression induced by low-frequency stimulation at hippocampal CA1 synapses, (R.Udagawa), M.Nakano, N.Kato, Brain Res.1124:28-36Nov. 2006
  • Mechanism of impairment of long-term potentiation by amyloid beta is independent of NMDA receptors or voltage-dependent calcium channels in hippocampal CA1 pyramidal neurons, (I.Nomura), N.Kato, T.Kita, H.Takechi, Neurosci lett.391:1-6Nov. 2005
  • Homer 1a enhances spike-induced calcium influx via L-type calcium channels in neocortex pyramidal cells, (K.Yamamota), Y.Sakagami, S.Sugiura, K.Inokuchi, S.Shimohama, N.Kato, The European journal of neuroscience22;1338-1348Sep. 2005
  • Essential roles of Homer-1a in homeostatic regulation of pyramidal cell excitability: a possible link to clinical benefits of electroconvulsive shock, (Y.Sakagami), K.Yamamoto, S.Sugiura, K.Inokuchi, T.Hayashi, N.Kato, Eur J Neurosci.21:3229-3239Jun. 2005
  • Learning impairment by minimal cortical injury in a mouse model of Alzheimer's disease., J.Zou, M.Wang, O.Uchiumi, Y.Shui, Y.Ishigaki, X.Liu, N.Tajima, T.Akai, H.Iizuka, N.Kato, Brain research1637:56-63Feb. 2016
  • Interplay between non-NMDA and NMDA receptor activation during oscillatory wave propagation: Analyses of caffeine-induced oscillations in the visual cortex of rats., (H.Yoshimura), T.Sugai, N.Kato, T.Tominaga, Y.Tominaga, T.Hasegawa, C.Yao, T.Akamatsu, Neural networks : the official journal of the International Neural Network Society79:141-149Apr. 2016
  • Long-term activation of group I metabotropic glutamate receptors increases functional TRPV1-expressing neurons in mouse dorsal root ganglia, T.Masuoka, M.Kudo, J.Yoshida, T.Ishibashi, I.Muramatsu, N.Kato, N.Imaizumi, M.Nishio, Frontiers in Cellular Neuroscience10:79-79Mar. 2016
  • JunB regulates angiogenesis and neurovascular parallel alignment in mouse embryonic skin, Y.Yoshitomi,T.Ikeda,H.Saito,Y.Yoshitake,Y.Ishigaki,T.Hatta,N.Kato,H.Yonekura, Jonal of Cell Science130:916-926Jan. 2017
  • Impaired retention of depression-like behavior in a mouse model of Alzheimer's disease., Xianwen.Luo, Yuan.Shui, Furong.Wang, Ryo.Yamamoto, Nobuo.Kato, IBRO Reports2:81-86May. 2017
  • Optogenetics Identification of a Neuronal Type with a Glass Optrode in Awake Mice., Munenori.Ono, Shinji.Muramoto, Lanlan.Ma, Nobuo.Kato, Journal of visualized experiments136:e57781Jun. 2018
  • Layer-specific modulation of pyramidal cell excitability by electroconvulsive shock, (Ueta Yoshifumi),Yamamoto Ryo,Kato Nobuo, NEUROSCIENCE LETTERS709:134383Sep. 2019
  • 24S-hydroxycholesterol alters activity of large-conductance Ca2+- dependent K+ (slo1 BK) channel through intercalation into plasma membrane, Tajima, Nobuyoshi;Liu Xiaoyan;Taniguchi, Makoto;Kato, Nobuo, BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS1864:1525-1535Oct. 2019
  • The enantiomer pair of 24S‐ and 24R‐hydroxycholesterol differentially alter activity of large‐conductance Ca2+‐dependent K+ (slo1 BK) channel, Xiaoyan Liu, Nobuyoshi Tajima, Makoto Taniguchi, Kato Nobuo, Chirality32:223-230Feb. 2020

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