KATO Nobuo

FacultyDepartment of Physiology Ⅰ

Researcher Profile & Settings



    Overview of research:
    Intracellular calcium is a versatile messenger involved in numerous intracellular processes. However, in particular cellular contexts, definite signals are adequately carried by calcium ions. How such context-dependent choice of adequate signals is achieved is studied by using two experimental paradigms in the neocortex: synaptic plasticiry and regulation of excitability.


  • Ph.D in Medicine

Research Activities

Published Papers

  • Remodeling of projections from ventral hippocampus to prefrontal cortex in Alzheimer's mice., Feng Xu, Munenori Ono, Tetsufumi Ito, Osamu Uchiumi, Furong Wang, Yu Zhang, Peng Sun, Qing Zhang, Sachiko Yamaki, Ryo Yamamoto, Nobuo Kato, The Journal of comparative neurology529:1486-1498May 2021
  • Amyloid β and Amyloid Precursor Protein Synergistically Suppress Large-Conductance Calcium-Activated Potassium Channel in Cortical Neurons, (Kenji Yamamoto), Ryo Yamamoto, Nobuo Kato, Frontiers in aging neuroscience13:660319Jan. 2021
  • Effects of a Lower Lipid Diet and Exercise on Cognitive Disturbances with the Induction of Calcineurin 1 and Brain-derived Neurotrophic Factor Expressions in the Hippocampi of Obese Apolipoprotein E Knockout Mice, Shuo Wang, Haicong Li, Mineko Nishijo, Yoshikazu Nishino, Nobuo Kato, Yuji Kasamaki, Tadashi Ueda, Tsugiyasu Kanda, JMA Journal4:409-4142021
  • Combination effects of a fatty diet and exercise on the depressive state and cardioprotection in apolipoprotein E knockout mice with a change in RCAN1 expression, Wang Shuo, Haicong Li, Nishijo Muneko, Nishino Yoshikazu, Nobuo Kato, Yuji Kasamaki, Tadashi Ueda, Tsugiyasu Kanda, Journal of International Medical Research48:300060520964016Nov. 2020
  • Significance of Autoantibodies in Autoimmune Encephalitis in Relation to Antigen Localization: An Outline of Frequently Reported Autoantibodies with a Non-Systematic Review, (Tanaka Keiko), Kawamura Meiko, Sakimura Kenji, Kato Nobuo, International Journal of Molecular Sciences21:4941Jul. 2020
  • Acoustic trauma induced the alteration of the activity balance of excitatory and inhibitory neurons in the inferior colliculus of mice, Lanlan Ma, Munenori Ono, Ling Qin, Nobuo Kato, Hearing Research391:107957Jun. 2020
  • Combinational Approach of Genetic SHP-1 Suppression and Voluntary Exercise Promotes Corticospinal Tract Sprouting and Motor Recovery Following Brain Injury, Tanaka Takashi, Ito Tetsufumi, Sumizono Megumi, Ono Munenori, Kato Nobuo, Honma Satoru, Ueno Masaki, Neurorehabilitation and Neural Repair34:558-570Jun. 2020
  • The enantiomer pair of 24S‐ and 24R‐hydroxycholesterol differentially alter activity of large‐conductance Ca2+‐dependent K+ (slo1 BK) channel, Xiaoyan Liu, Nobuyoshi Tajima, Makoto Taniguchi, Nobuo Kato, Chirality32:223-230Feb. 2020
  • Serotonergic control of GABAergic inhibition in the lateral amygdala, Ryo Yamamoto, Takafumi Furuyama, Tokio Sugai, Munenori Ono, Denis Pare, Nobuo Kato, Journal of Neurophysiology123:670-681Feb. 2020
  • 24S-hydroxycholesterol alters activity of large-conductance Ca2+- dependent K+ (slo1 BK) channel through intercalation into plasma membrane, Tajima, Nobuyoshi;Liu Xiaoyan;Taniguchi, Makoto;Kato, Nobuo, BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS1864:1525-1535Oct. 2019
  • Layer-specific modulation of pyramidal cell excitability by electroconvulsive shock, (Ueta Yoshifumi),Yamamoto Ryo,Kato Nobuo, NEUROSCIENCE LETTERS709:134383Sep. 2019
  • Optogenetics Identification of a Neuronal Type with a Glass Optrode in Awake Mice., Munenori.Ono, Shinji.Muramoto, Lanlan.Ma, Nobuo.Kato, Journal of visualized experiments136:e57781Jun. 2018
  • Impaired retention of depression-like behavior in a mouse model of Alzheimer's disease., Xianwen.Luo, Yuan.Shui, Furong.Wang, Ryo.Yamamoto, Nobuo.Kato, IBRO Reports2:81-86May 2017
  • JunB regulates angiogenesis and neurovascular parallel alignment in mouse embryonic skin, Y.Yoshitomi,T.Ikeda,H.Saito,Y.Yoshitake,Y.Ishigaki,T.Hatta,N.Kato,H.Yonekura, Jonal of Cell Science130:916-926Jan. 2017
  • Interplay between non-NMDA and NMDA receptor activation during oscillatory wave propagation: Analyses of caffeine-induced oscillations in the visual cortex of rats., (H.Yoshimura), T.Sugai, N.Kato, T.Tominaga, Y.Tominaga, T.Hasegawa, C.Yao, T.Akamatsu, Neural networks : the official journal of the International Neural Network Society79:141-149Apr. 2016
  • Long-term activation of group I metabotropic glutamate receptors increases functional TRPV1-expressing neurons in mouse dorsal root ganglia, T.Masuoka, M.Kudo, J.Yoshida, T.Ishibashi, I.Muramatsu, N.Kato, N.Imaizumi, M.Nishio, Frontiers in Cellular Neuroscience10:79-79Mar. 2016
  • Learning impairment by minimal cortical injury in a mouse model of Alzheimer's disease., J.Zou, M.Wang, O.Uchiumi, Y.Shui, Y.Ishigaki, X.Liu, N.Tajima, T.Akai, H.Iizuka, N.Kato, Brain research1637:56-63Feb. 2016
  • Induction of memory deficit in mice with chronic exposure to cerebrospinal fluid from patients with Anti-N-Methyl-D-Aspartate receptor encephalitis, Y.Li, K.Tanaka, L.Wang, Y.Ishigaki, N.Kato, The Tohoku Journal of Experimental Medicine237:329-338Nov. 2015
  • Improvement of spatial learning by facilitating large-conductance calcium-activated potassium channel with transcranial magnetic stimulation in Alzheimer's disease model mice, F.Wang, Y.Zhang, L.Wang, P.Sun, X.Luo, Y.Ishigaki, T.Sugai, R.Yamamoto, N.Kato, Neuropharmacology97:210-219Jun. 2015
  • Homer1a-dependent recovery from depression-like behavior by photic stimulation in mice, P Sun, Q Zhang, Y Zhang, F Wang, R Chen, R Yamamoto, N Kato, Physiology & Behavior147:334-341Mar. 2015
  • Homer1a disruption increases vulnerability to predictable subtle stress normally sub-threshold for behavioral changes, Y.Shui, L.Wang, X.Luo, O.Uchiumi, R.Yamamoto, T.Sugai, N.Kato, Brain Research.1605:70-75Feb. 2015
  • Expression of hyaluronidase-4 in a rat spinal cord hemisection model, Y.Tachi, T.Okuda, N.Kawahara, N.Kato, Y.Ishigaki, T.Matsumoto, Asian Spine Journal9:7-13Feb. 2015
  • Biphasic modulation by mGlu5 receptors of TRPV1-mediated intracellular calcium elevation in sensory neurons contributes to heat sensitivity., T.Masuoka, T.Nakamura, M.Kudo, J.Yoshida, Y.Takaoka, N.Kato, T.Ishibashi, N.Imaizumi, M.Nishio, British Journal of Pharmacology172:1020-1033Feb. 2015
  • Fear conditioning suppresses large-conductance calcium-activated potassium channels in lateral amygdala neurons., P.Sun, Q.Zhang, Y.Zhang, F.Wang, L.Wang, R.Yamamoto, T.Sugai, N.Kato, Physiology & Behavior138:279-284Jan. 2015
  • Cognitive recovery by chronic activation of the large-conductance calcium-activated potassium channel in a mouse model of Alzheimer's disease, L.Wang, H.Kang, Y.Li, Y.Shui, R.Yamamoto, T.Sugai, N.Kato, Neuropharmacology92:8-15Jan. 2015
  • Cognitive improvement by photic stimulation in a mouse model of Alzheimer's disease, Y.Zhang, F.Wang, X.Luo, L.Wang, P.Sun, M.Wang, Y.Jiang, J.Zou, O.Uchiumi, R.Yamamoto, T.Sugai, K.Yamamoto, N.Kato, Current Alzheimer Research12:860-8692015
  • Serotonin induces depolarization in lateral amygdala neurons by activation of TRPC-like current and inhibition of GIRK current depending on 5-HT2C receptor, R.Yamamoto; N.Hatano; T.Sugai;N.Kato, Neuropharmacology82:49-58Mar. 2014
  • Enhancement of oscillatory activity in the endopiriform nucleus of rats raised under abnormal oral conditions., (H.Yoshimura), M.Hasumoto, T.Sugai, N.Segami, N.Kato, Neurosci Lett.561:162-165Feb. 2014
  • Age-dependent emergence of caffeine-assisted voltage oscillations in the endopiriform nucleus of rats., H.Yoshimura, T.Sugai, T.Hasegawa, C.Yao, T.Akamatsu, N.Kato, Neurosci Res.76:16-21May 2013
  • Role of the lateral habenula in shaping context-dependent locomotor activity during cognitive tasks., Z-D Wang, L Wang, R.Yamamoto, T.Sugai, N.Kato, Neuroreport.24:276-280Jan. 2013
  • Cardiac BDNF/TrkB signaling can be induced by calorie restriction with improved physical activity in obese mice., T.Kanda, R.Chen, T.Mizuno, D.Sakamoto, D.Usuda, M.Mori, M.Takahashi, N.Kato, H.Sumino, The Internet Journal of Cardiovascular Research82013
  • Multimodal cross-talk of olfactory and gustatory information in the endopiriform nucleus in rats, T.Sugai, R.Yamamoto, H.Yoshimura, N.Kato, Chemical senses.37:681-688Oct. 2012
  • Suppression of synaptic plasticity by cerebrospinal fluid from anti-NMDA receptor encephalitis patients, Q.Zhang, K.Tanaka, P.Sun, M.Nakata, R.Yamamoto, K.Sakimura, M.Matsui, N.Kato, Neurobiol Dis.45:610-615Jan. 2012
  • Intraneuronally injected amyloid beta inhibits long-term potentiation in rat hippocampal slices, I.Nomura, H.Takechi, N.Kato, J Neurophysiol.107:2526-25312012
  • A serotonergic discrimination favoring synaptic inputs that accompany robust spike firing in lateral amygdala neurons, R.Yamamoto, Y.Ueta, T.Sugai, N.Kato, Neuroscience.220:119-1302012
  • Increase in cortical pyramidal cell excitability accompanies depression-like behavior in mice: a transcranial magnetic stimulation study, P.Sun, F-R.Wang, L.Wang, Yu.Zhang, R.Yamamoto, T.Sugai, Q.Zhang, Z-D.Wang, N.Kato, J Neurosci.31:16464-16472Nov. 2011
  • Influences of audio-visual environments on feelings of deliciousness during having sweet foods: an electroencephalogram frequency analysis study, H.Yoshimura, M.Honjyo, T.Sugai, M.Kawabe, K.Kaneyama, N.Segami, N.Kato, Nutritional Neurosci.14:210-215Sep. 2011
  • Suppression of a neocortical potassium channel activity by intracellular amyloid-β and its rescue with homer1a, K.Yamamoto, Y.Ueta, L.Wang, R.Yamamoto, N.Inoue, K.Inokuchi, A.Aiba, H.Yonekura, N.Kato, J Neurosci.31:11100-11109Aug. 2011
  • Correlation between stimulation strength and onset time of signal traveling within the neocortical neural circuits under caffeine application, H.Yoshimura, M.Honjyo, T.Sugai, K.Kaneyama, N.Segami, N.Kato, Neurosci Res.70:370-375Aug. 2011
  • Evaluations of dementia by EEG frequency analysis and psychological examination, H.Yoshimura, S.Morimoto, M.Okuro, N.Segami, N.Kato, J Physiol Sci : JPS60:383-388Sep. 2010
  • Application of caffeine reveals input frequency-dependent determination of signal-traveling routes between primary and secondary visual cortices in rats, H.Yoshimura, T.Sugai, M.Honjo, K.Kaneyama, N.Segami, N.Kato, Neurosci Res.66:30-36Oct. 2009
  • Neurophysiological mechanisms of electroconvulsive therapy for depression., N.Kato, Neurosci Res.64:3-11May 2009
  • Functional connections between olfactory and gustatory information via the endopiriform nucleus in the rat., T.Sugai, R.Yamamoto, H.Yoshimura, N.Kato15:345-346Dec. 2008
  • Multiple tooth-losses during development suppress age-dependent emergence of oscillatory neural activities in the oral somatosensory cortex., H.Yoshimura, M.Honjo, Y.Mashiyama, K.kaneyama, N.Segami, J.Sato, T.Sugai, N.kato, N.Onoda, Brain Res.1224:37-42Aug. 2008
  • Homer 1a suppresses neocortex long-term depression in a cortical layer-specific manner., Y.Ueta, R.Yamamoto, S.Sugiura, K.Inokuchi, N.Kato, J Neurophysiol.99:950-9572008
  • Signal propagation between the piriform cortex and the endopiriform nucleus in the rat horizontal slice preparation., T.Sugai, R.Yamamoto, H.Yoshimura, N.Kato14:521-522Dec. 2007
  • Dopamine induces a slow afterdepolarization in lateral amygdale neurons., R.Yamamoto, Y.Ueta, N.Kato, J Neurophysiol.98:984-992Aug. 2007
  • Autocorrelogram sorting: A novel method for evaluating negative-feedback regulation of spike firing., (M.Murata), N.Kato, Brain Res.1133:27-33Feb. 2007
  • Component-dependent urine responses in the rat accessory olfactory bulb, T.Sugai, H.Yoshimura, N.Kato, N.Onoda, Neuroreport.17:1663-1667Nov. 2006
  • Blocking L-type calcium channels enhances long-term depression induced by low-frequency stimulation at hippocampal CA1 synapses, (R.Udagawa), M.Nakano, N.Kato, Brain Res.1124:28-36Nov. 2006
  • Mechanism of impairment of long-term potentiation by amyloid beta is independent of NMDA receptors or voltage-dependent calcium channels in hippocampal CA1 pyramidal neurons, (I.Nomura), N.Kato, T.Kita, H.Takechi, Neurosci lett.391:1-6Nov. 2005
  • Homer 1a enhances spike-induced calcium influx via L-type calcium channels in neocortex pyramidal cells, (K.Yamamota), Y.Sakagami, S.Sugiura, K.Inokuchi, S.Shimohama, N.Kato, The European journal of neuroscience22;1338-1348Sep. 2005
  • Essential roles of Homer-1a in homeostatic regulation of pyramidal cell excitability: a possible link to clinical benefits of electroconvulsive shock, (Y.Sakagami), K.Yamamoto, S.Sugiura, K.Inokuchi, T.Hayashi, N.Kato, Eur J Neurosci.21:3229-3239Jun. 2005
  • Pain-related neuronal ensembles in the primary somatosensory cortex contribute to hyperalgesia and anxiety, (Tatsuya Ishikawa), Koshi Murata, Hiroaki Okuda, Ilia Potapenko, Kiyomi Hori, Takafumi Furuyama, Ryo Yamamoto, Munenori Ono, Nobuo Kato, Yugo Fukazawa, Noriyuki Ozaki, iScience26:106332Mar. 2023