KAWAI Yasuyuki

■FacultyDepartment of Cardiology
■PositionProfessor

Researcher Profile & Settings

Research

    Overview of research:
    1. Clinical use of deoxiribonuclease I 2. Study on pro-atherosclerotic effects of aldosterone and salt

Education

  • Fukui Medical School Graduate School Division of Medicine

Research Activities

Published Papers

  • Comparison of serum cell-free DNA between postmortem and living samples., (Fujihara Junko), Takinami Yoshikazu, Kawai Yasuyuki, Kimura-Kataoka Kaori, Takeshita Haruo, Clinica chimica acta; international journal of clinical chemistry, 519:255, 2021
  • Monitoring the roles of prothrombin activation fragment 1 and 2 (F1+2) in patients with atrial fibrillation receiving rivaroxaban and apixaban, Ueno Ei-ichi, Fujibayashi Kosuke, Sawaguchi Jun, Yasuda Yushi, Takano Shintaro, Fujioka Nakaba, Kawai Yasuyuki, Fujita Harumi, Tanaka Yoshi, Kajinami Kouji, Journal of Thrombosis and Thrombolysis, 50:371-379, Aug. 2020
  • Preliminary quantitative evaluation of radiation-induced DNA damage in peripheral blood lymphocytes after cardiac dual-isotope imaging, Koichi Okuda, Naoto Watanabe, Mitsumasa Hashimoto, Mariko Doai, Yasuyuki Kawai, Tomoko Takahashi, Tomohiro Arikawa, Kazumasa Ooiso, Yumi Sunatani, Kuniyoshi Iwabuchi, Koji Kajinami, Munetaka Matoba, Applied Radiation and Isotopes, 154:108890, Dec. 2019
  • Evaluation of the functional effects of genetic variants-missense and nonsense SNPs, indels and copy number variations-in the gene encoding human deoxyribonuclease I potentially implicated in autoimmunity, (Misuzu Ueki), Kaori Kimura-Kataoka, Junko Fujihara, Reiko Iida, Yasuyuki Kawai, Akari Kusaka, Takamitsu Sasaki, Haruo Takeshita, Toshihiro Yasuda, SCIENTIFIC REPORTS, 9:13660, Sep. 2019
  • Circulating malondialdehyde-modified low-density lipoprotein (MDA-LDL) as a novel predictor of clinical outcome after endovascular therapy in patients with peripheral artery disease (PAD), Takamura, Taka-aki;Tsuchiya, Taketsugu;Oda, Minako;Watanabe, Makoto;Saito, Ryuhei;Sato-Ishida, Ryoko;Akao, Hironobu;Kawai, Yasuyuki;Kitayama, Michihiko;Kajinami, Kouji, ATHEROSCLEROSIS, 263:192-197, Aug. 2017
  • Diurnal glycemic fluctuation is associated with severity of coronary artery disease in prediabetic patients: Possible role of nitrotyrosine and glyceraldehyde-derived advanced glycation end products., M.Watanabe, Y.Kawai, M.Kitayama, H.Akao, A.Motoyama, M.Wakasa , R.Saito, H.Aoki, K.Fujibayashi, T.Tsuchiya, H.Nakanishi, K.Saito, M.Takeuchi, K.Kajinami, Journal of Cardiology, 69:625-631, Apr. 2017
  • Chronic total occlusions of the right coronary and left anterior descending coronary arteries in a young adult patient with antiphospholipid syndrome, Y.Kawai, M.Kitayama, A.Motoyama, M.Wakasa, R.Saito, H.Aoki, K.Fujibayashi, M.Watanabe, T.Takamura, H.Akao, T.Tsuchiya, K.Kajinami, Journal of Cardiology Cases, 14:46-48, Aug. 2016
  • A possible role for HLA-DRB1*04:06 in statin-related myopathy in Japanese patients, (K.Sai), K.Kajinami, H.Akao, M.Iwadare, R.Sato-Ishida, Y.Kawai, K.Takeda, T.Tanimoto, T.Yamano, T.Akasaka, T.Ishida, K.Hirata, K.Saku, S.Yagi, T.Soeki, M.Sata, M.Ueno, S.Miyazaki, A.Shiraki, J.Oyama, K.Node, K.Sugamura, H.Ogawa, K.Kurose, K.Maekawa, Y.Matsuzawa, T.Imatoh, R.Hasegawa, Y.Saito, Drug metabolism and pharmacokinetics, 31:467-470, 2016
  • Circulating Glutamate and Taurine Levels Are Associated with the Generation of Reactive Oxygen Species in Paroxysmal Atrial Fibrillation, S.Takano, K.Fujibayashi, N.Fujioka, E.Ueno, M.Wakasa, Y.Kawai, K.Kajinami, Disease Markers, 2016:1-7, 2016
  • Nutri-pharmacogenomics of warfarin anticoagulation therapy : VKORC1 genotype-dependent influence of dietary vitamin K intake, R.Saito, K.Takeda, K.Yamamoto, A.Nakagawa, H.Aoki, K.Fujibayashi, M.Wakasa, A.Motoyama, M.Iwadare, R.Ishida, N.Fujioka, T.Tsuchiya, H.Akao, Y.Kawai, M.Kitayama, K.Kajinami, Journal of thrombosis and thrombolysis., 38:105-114, Jul. 2014
  • Increased levels of the oxidative stress marker, nitrotyrosine in patients with provocation test-induced coronary vasospasm, K.Tanabe, Y.Kawai, M.Kitayama, H.Akao, R.Ishida, A.Motoyama, M.Wakasa, R.Saito, H.Aoki, K.Fujibayashi, M.Watanabe, T.Tsuchiya, H.Kimura, K.Yoshida, K.Kajinami, Journal of cardiology, 64:86-90, Jan. 2014
  • Chk1-mediated phosphorylation of receptor-associated late transducer at serine 250 increases its stability by stimulating its interaction with 14-3-3., K.Takeda, T.Takata, Y.Kawai, Y.Ishigaki, K.Kajinami, Genes to cells : devoted to molecular & cellular mechanisms, 18:369-386, 2013
  • The mitochondria mediate the induction of NOX1 gene expression by aldosterone in an ATF-1-dependent manner, (Fu Y), Shi G, Wu Y, Kawai Y, Tian Q, Yue L, Xia Q, Miyamori I, Fan C, Cell Mol Biol Lett, 16: 156-163, Jun. 2011
  • Activation of Src-ATF1 pathway is involved in upregulation of NOX1, a catalytic subunit of NADPH oxidase, by aldosterone, (Shi G), Fu Y, Jiang W, Yin A, Feng M, Wu Y, Kawai Y, Miyamori I, Fan C, Endocr J, 58: 491-499, Apr. 2011
  • Beyond C-reactive Protein; new evidence for another inflammatory biomarker predicting cardiovascular disease risk, K.Kajinami, Y.Kawai, Atherosclerosis., 214:39-40, 2011
  • Abnormal myocardial energy-production state in mitochondrial cadiomyopathy and acute response to L-arginine infusion: C-11 acetate kinetics revealed by positron emission tomography, (K. Arakawa), T. Kudoh, M. Ikawa, N. Morikawa, Y.Kawai, J. Lee, M. Kuriyama, I. Miyamori, H. Okazawa, M. Yoneda, Circulation Journal, 74:2702-2711, Nov. 2010
  • Levels of serum deoxyribonuclease Ⅰactivity on admission in patients with acute myocardial infarction can be useful in predicting left ventricular enlargement due to remodeling, (J.Kuribara), H.Tada, Y.Kawai, R.Kawaguchi, H.Hoshizaki, K.Arakawa, M.Kitayama, K.Kajinami, M.Kurabayashi, S.Oshima, K.Taniguchi, Y.Kominato, T.Yasuda, Journal of cardiology, 53:196-203, Oct. 2009
  • Synergy of aldosterone and high salt induces vascular smooth muscle hypertrophy through up-regulation of NOX1, (CY Fan), Y.Kawai, M Katsuyama, C Yabe-Nishimura, K Arakawa, T Yasuda, K.Kajinami, S Inaba, T Konoshita, I Miyamori, J Steroid Biochem Mol Biol, 111:29-36, Aug. 2008
  • Regulation of pssitive feedback loop of HB-EGF signal by gene 33/ralt in H9c2 cells, K.Takeda, S.Akazawa, Y.Kawai, K.Kajinami, 33:76-85, Aug. 2008
  • Association of Gln222Arg polymorphism in the deoxyribonuclease I (DNase I) gene with myocardial infarction, 16; 189-193, Jun. 2008
  • Serum deoxyribonuclease I activity can be used as a novel marker of transient myocardial ischemia:results in vasospastic angina pectoris induced by provocation test, (N.Morikawa), Y.Kawai, K.Arakawa, T.Kumamoto, I.Miyamori, H.Akao, M.Kitayama, K.Kajinami, Jong-Dag Lee, H.Takeshita, Y.Kominato, T.Yasuda, European heart journal, 28:2992-2997, Dec. 2007
  • Evaluation of respiratory chain failure in mitochondrial cardiomyopathy by assessment of (99m)Tc-MIBI washout and (123)I-BMIPP/(99m)Tc-MIBI mismatch, (M Ikawa), Y Kawai, K Arakawa, T Tsuchida, I Miyamori, M Kuriyama, M Tanaka, M Yonada, Mitochondrion, 7:164-170, Apr. 2007
  • Expression of mineralocorticoid receptor and effect of aldosterone blocker in failing heart, Endocrinology & Diabetology, 23:607-612, Dec. 2006
  • Association of Gln222Arg polymorphism in the deoxiribonuclease I (DNase1) gene with myocardial infarction in the Japanese patients, (T. Kumamoto), Y. Kawai, K. Arakawa, N. Morikawa, J. Kuribara, H. Tada, K. Taniguchi, R. Tatami, I. Myamori, Y. Kominato, K. Kishi, T. Yasuda, Eur Heart J., 27:2081-2087, Sep. 2006
  • Characterization of human deoxiribonuclease I gene (DNASE 1) promoters reveals the utilization of two transcription-starting exons an the involvement of Sp1 in its transcriptional regulation, (Y. Kominato), M. Ueki, R. Iida, Y. Kawai, T. Nakajima, C. Makita, M. Itoi, Y. Tajima, K. Kishi, T. Yasuda, FEBS J., 273:3094-3105, Jan. 2006
  • Serum deoxiribonuclease I activity can be used as a sensitive marker for detection of transient myocardial ischaemia induced by percutaneous coronary intervention, (K. Arakawa), Y. Kawai, T. Kumamoto, N. Morikawa, M. Yoshida, H. Tada, R. Kawaguchi, K. Taniguchi, I. Miyamori, Y. Kominato, K. Kishi, T. Ysuda, Eur Heart J., 26.2375-2380, Oct. 2005
  • A novel variable tandem repeat polymorphism in human deoxiribonuclease I gene, DNA polymorphism, 13:38-40, Jun. 2005
  • Clinical applications of DNase I, a genetic marker already used for forensic identification, (T. Yasuda), Y. Kawai, M. Ueki, K. Kishi, Legal Medicine, 7:274-277, Apr. 2005
  • Mineralocorticoid receptor is overexpressed in cardiomyocytes of patients with congestive heart failure, (M. Yoshida), J. Ma, T. Tomita, N. Morikawa, N. Tanaka, K. Masamura, Y. Kawai, I. Miyamori, Congest. Heart Fail., 11:12-16, Jan. 2005
  • Survey of the association of SNP in human deoxiribonuclease I gene with diseases, DNA polymorphism, 12:276-279, Jun. 2004
  • Diagnostic use of serum deoxiribonuclease I activity as a novel early-phase marker in acute myocardial infarction, Y. Kawai, M. Yoshida, K. Arakawa, T. Kumamoto, N. Morikawa, K. Masamura, H. Tada, S. Ito, H. Hoshizaki, S. Oshima, K. Taniguchi, H. Terasawa, I. Miyamori, K. Kishi, T. Yasuda, Circulation., 109:2398-2400, Jun. 2004
  • Amphiregulin is a potent mitogen for the vascular smooth muscle cell line, A7r5, (M. Kato), T. Inazu, Y. Kawai, K. Masamura, M. Yoshida, N. Tanaka, K. Miyamoto, I. Miyamori, Biochemical and biophysical research communications, 301:1109-1115, Apr. 2003
  • A role of heparin-binding epidermal growth factor-like growth factor in cardiac remodeling after myocardial infarction, (N. Tanaka), K. Masamura, M. Yoshida, M. Kato, Y. Kawai, I. Miyamori, Biochemical and biophysical research communications, 297:375-381, Apr. 2002
  • A case of paroxysmal atrioventricular block induced by abrupt change in head position, ４７：299-302, May 1999
  • Effects of brief glucocorticoid exposure on growth of vascular smooth muscle cells in culture, Y. Kawai, T. Hayashi, K. Eguchi, K. Asazuma, K. Masamura, A. Iwamuro, Y. Takano, H. Tada, S. Matsukawa, I. Miyamori, Biochemical and biophysical research communications, 245:493-496, Jun. 1998