FacultyMedical Science, Division of Vision Research for Environmental Health, Department of Ophthalmology

Researcher Profile & Settings


    Overview of research:
    In vivo animal experiment for ocular injury by electromagnetic exposure such as ultraviolet, visible light, infrared, microwave, and millimeter wave are investigating. Besides this, risk factors of cataract development and cataract promotion factor are investigation from epidemiological study of ophthalmology in different environmental conditions.

Special Field

  • Ophthalmology


  • Kobe Gakuin University Faculty of Nutrition


  • Doctor of Medicine

Association Memberships

  • 20012004The Association for Research in Vision and Ophthalmology International Members Committee
  • 1996European Association for Vision and Eye Research Member
  • 1986The International Society for Eye Research Member
  • 19972000International Society of Ocular Toxicology Director
  • 19982015Scheimpflug Club for Eye Research Director
  • 19962003Japan Contact Lens Society Member
  • 1885Nippon Ganka Gakkai (Japanese Ophthalmological Society) Member
  • 1984Japanese Society for Ocular Pharmacology Member
  • 20012015The Japanese Society for Cataract Research Board of Tustees

Academic & Professional Experience

  • Apr. 1982Mar. 1985Kanazawa Medical University trainee
  • Apr. 1985Mar. 1988Kanazawa Medical University
  • Jan. 1988Feb. 1991Alexander von Humboldt Foundation
  • 1995Mar. 2007Kanazawa Medical University lecturer
  • Apr. 2007Kanazawa Medical University Associate Professor

Research Activities

Published Papers

  • Ultraviolet B-induced Otx2 expression in lens epithelial cells promotes epithelial-mesenchymal transition, Yoshitomi Y, Osada H, Satake H, Kojima M, Saito-Takatsuji H, Ikeda T, Yoshitake Y, Ishigaki Y, Kubo E, Sasaki H, Yonekura H, Biology Open8:bio035691Feb. 2019
  • Ocular Effects of Exposure to 40, 75, and 95 GHz Millimeter Waves, Masami Kojima, Yukihisa Suzuki, Kensuke Sasaki, Masao Taki, Kanako Wake, Soichi Watanabe, Maya Mizuno, Takafumi Tasaki, Hiroshi Sasaki, Journal of Infrared, Millimeter, and Terahertz Waves39:912-925Sep. 2018
  • Dielectric property measurement of ocular tissues up to 110 GHz using 1 mm coaxial sensor, (K.Sasaki), Y.Isimura, K.Fujii, K.Wake, S.Watanabe, M.Kojima, R.Suga, O.Hashimoto, Physics in Medicine and Biology60:6273-6288Aug. 2015
  • Characteristics of ocular temperature elevations after exposure to quasi- and millimeter waves (18-40 GHz), M.Kojima, Y.Suzuki, CY.Tsai, K.Sasaki, K.Wake, S.Watanabe, M.Taki, Y.Kamimura, A.Hirata, K.Sasaki, H.Sasaki, Journal of Infrared Millimeter and Terahertz Waves36:390-399Apr. 2015
  • Dosimetry on high-frequency electromagnetic field exposure with micro-encapsulated thermo-chromic liquid crystal, (Y.Suzuki), M.Taki, M.Kojima, IEICE technical report:1-62015
  • Dosimetry using a localized exposure system in the Millimeter-Wave band for in vivo studies on ocular effects, (K.Sasaki), T.Sakai, T.Nagaoka, K.Wake, S.Watanabe, M.Kojima, N.Hasanova, H.Sasaki, K.Sasaki, Y.Suzuki, M.Taki, Y.Kamimura, A.Hirata, H.Shirai, IEEE transactions on microwave theory and techniques62:1554-1564Jul. 2014
  • FDTD analysis of temperature elevation in the lens of human and rabbit models due to near-field and far-field exposures at 2.45 GHz., (T.Oiszmi), I.Laakso, A.Hirata, O.Fujiwara, S.Watanabe, M.Taki, M.Kojima, H.Sasaki, K.Sasaki, Radiation protection dosimetry.155:284-291Jul. 2013
  • Acute dosimetry and estimation of threshold-inducing behavioral signs of thermal stress in rabbits at 2.45-GHz microwave exposure, (A.Hirata), M.Kojima, H.Kawai, Y.Yamashiro, S.Watanabe, H.Sasaki, O.Fujiwara, IEEE transactions on microwave theory and techniques57:1234-1242May. 2010
  • Effect of 5-S-GAD on UV-B-Induced cataracts in rats, H.Kawada, M.Kojima, T.Kimura, S.Natori, K.Sasaki, H.Sasaki, Japanese journal of ophthalmology.53:531-535Sep. 2009
  • Assessment of pinguecula and pterygium in the aging eye with ultraviolet fluorescence photography (UVFP) : Data analysis of eye disease survey in Shanxi, China, K.Sasaki, Y.Yamashiro, M.Kojima, R.Honda, Y.Sakamoto, HM.Cheng, H.Sasaki5:31-40Mar. 2009
  • Computation of temperature elevation in rabbit eye irradiated by 2.45-GHz microwaves with different field configurations, (A.Hirata), S.Watanabe, M.Taki, O.Fujiwara, M.Kojima, K.Sasaki, Health physics.92:134-144Feb. 2008
  • Temperature elevation in the eye of anatomically based human head models for plane-wave exposures, (A.Hirata), S.Watanabe, O.Fujiwara, M.Kojima, K.Sasaki, T.Shiozawa, Physics in medicine and biology52:6389-6399Oct. 2007
  • Current status about blindness among low‐income farmers in Sanya district, hainan, China, Q.Jingtao, H.Sasaki, L.Zhongxin, Z.Jinsheng, W.Kaili, M.Kojima, Y.Sakamoto, R.Honda, Y.Kawakami, Y.Yamashiro, Z.Jinsong, K.Sasaki, Japan-China Co-operative Study Group61:411-416Mar. 2007
  • Development of a 2.45-GHz local exposure system for In Vivo study on ocular effects, (K.Wake), H.Hongo, S.Watanabe, M.Taki, Y.Kamimura, Y.Yamanaka, T.Uno, M.Kojima, I.Hata, K.Sasaki, IEEE transactions on microwave theory and techniques55:588-596Mar. 2007
  • Efficacy of α-lipoic acid against diabetic cataract in rat, M.Kojima, L.Sun, I.Hata, Y.Sakamoto, H.Sasaki, K.Sasaki, Japanese journal of ophthalmology.51:10-13Jan. 2007
  • Temperature elevation in the eye of Japanese male and female models for plane wave exposures, (A.Hirata), S.Watanabe, O.Fujiwara, M.Kojima, K.Sasaki, T.Shiozawa, EMC17:29-32Oct. 2006
  • Temperature elevation in rabbit eye irradiated by 2.45-GHz exposure systems, (A.Hirata), S.Watanabe, M.Taki, O.Fujiwara, M.Kojima, K.Sasaki, THE INSTITUTE OF ELECTRONICS, INFORMATION AND COMMUNICATION ENGINEERS50:29-34Oct. 2006
  • Computational verification of anesthesia effect on temperature variations in rabbit eyes exposed to 2.45 GHz microwave energy, (A.Hirata), S.Watanabe, M.Kojima, I.Hata, K.Wake, M.Taki, K.Sasaki, O.Fujisawa, T.Shiozawa, Bioelectromagnetics27:602-612Aug. 2006
  • Differential analysis of D-β-Asp- containing proteins found in normal and infrared irradiated rabbit lens, (T.Takata), T.Shimo-Oka, M.Kojima, K.Miki, N.Fujii, Biochemical and biophysical research communications344:263-271Jan. 2006
  • The effects of protective eyewear on glare and crystalline lens transparency, KOJIMA Masami, Developments in Ophthalmology2002
  • Infrared cataract and intraocular temperature, KOJIMA Masami, Photomedicine and Photobiology2002
  • Environmental temperature and cataract progression in experimental rat cataract model, KOJIMA Masami, Developments in Ophthalmology2002
  • Intracameral and lenticular penetration of locally applied stable isotope-labeled vitamin E, KOJIMA Masami, Jap J. Ophthalmol2001
  • Cortical lens opacification in Iceland risk factor analysis-Reykjavik Eye Study-, KOJIMA Masami, Acta Ophthalmol. Scand2001
  • Characteristics of cataracts in the Chineses Singaporean, KOJIMA Masami, J. Epidemiol2001
  • Acute ultraviolet B induced lens epithelial cell photo-damage and its repair process, KOJIMA Masami, J Jpn Ophthalmol Soc2001
  • Ultraviolet exposure as a risk factor of cataract formation, KOJIMA Masami, Environmental Sciences2000
  • The effect of iris melanin in the crystalline lens light injury-Ultraviolet ray protective effect of the pigmented and albino iris.-, KOJIMA Masami, Proceedings of the Japanese Committee for Sunlight Protection2000
  • Solar UV-Light Induced Ocular Diseases, KOJIMA Masami, Environmental Sciences2000
  • Reykjavik Eye Study-Prevalence of Lens Opacification with reference to identical Japanese Studies., KOJIMA Masami, Ophthalmologica2000
  • Morphological observation on all death and phagocytosis induced by ultraviolet irradiation in a cultured human lens epithelial cell line, KOJIMA Masami, Exp. Eye Res2000
  • Long-term observation of lens findings noticed in NC/Num mouse, KOJIMA Masami, J. Kanazawa Med. Univ.2000
  • Lens changes in rat eyes induced solely by long term administration of Prednisolone sodium succinate, KOJIMA Masami, J. Kanazawa Med. Univ.2000
  • Intracameral and lenticalar penetration of locally applied deuterium-labeled vitamin E in rats, KOJIMA Masami, J Jpn Ophthalmol Soc2000
  • High hurdle of clinical trials to demonstrate efficacy of anticataractogenic drugs, KOJIMA Masami, Ophthalmologica2000
  • Effect of environmental temperature on cataract progression in diabetic rats, KOJIMA Masami, Atarashii Ganka(J Eye)2000
  • UV damage to the eye lens : further results from animal model studies : a review, KOJIMA Masami, J. Epidemiol1999
  • Epidemiological survey of ocular diseases in K island, Amami Islands : Prevalence of Cataract and Pterygium, KOJIMA Masami, Journal of Japanese Ophthalmological Society1999
  • Epidemiological survey of Ocular diseases in K island, Amami islands Prevalence of cataract and Pterygium, KOJIMA Masami, J Jpn Ophthalmol Soc1999
  • Epidemiological studies on UV-related cataract in climatically different countries, KOJIMA Masami, J. Epidemiol1999
  • Effectiveness of eyeglasses for protection against ultraviolet, KOJIMA Masami, Journal of Japanese Ophthalmological Society1999
  • Effectiveness of eyeglasses for Protection against ultraviolet rays, KOJIMA Masami, J Jpn Opthalmol Soc1999
  • Effect of vitamin E eye drops on naphthalene-induced cataract in rats, KOJIMA Masami, Journal of Ocular Pharmacology and Therapeutics1999
  • Effect of vitamin E eye drops on naphthalene induced cataract in rats, KOJIMA Masami, Journal of Ocular Pharmacology and Therapeutics1999
  • Changes in eyelid fissure height and pupillary size induced by different illuminations, KOJIMA Masami, Rinsho Ganka(Jpn J Clin Ophthalmol)1999
  • Changes in eyelid fissure height and pupillary size induced by different illuminations, KOJIMA Masami, Japanese Jornal of Clinical Ophthalmology(RINSHO GANKA)1999
  • Characteristics of lens figures observed in patients with atopic dermatitis and their systemic background, KOJIMA Masami, Journal of Kanazawa Medical University1999
  • Repairing process of rabbit lens epithelial cells dameged by ultraviolet-B, KOJIMA Masami, Journal of Kanazawa Medical University1998
  • Relation between ultra-violet and cataract, KOJIMA Masami1998
  • Lens epithelium cells damege-Comparison of ultraviolet sensitivity between Rats and guinea pigs-, KOJIMA Masami1998
  • Lens changes observed in NC/Nga mice with dermatitis, KOJIMA Masami, Jornal of Kanazawa Medical University1998
  • Early lens chages seen in patients with atopic dermatitis applying image analysis processing of Scheimpflug and specular microscopic images, KOJIMA Masami, Ophthalmologica1998
  • Ultraviolet dosimetry utilizing a mannequin model, KOJIMA Masami, Developments in Ophthalmology, Cataract Epidemiology, Karger1997
  • Ultraviolet as a risk factor for the cataract development -It's direct and indirect effects-, KOJIMA Masami, Proceedings of the Japanese Committee for Sunlight Protection1997
  • Relationship between pure cortical cataract appearance and the wearing of Glasses, KOJIMA Masami, Developments in Ophthalmology, Cataract Epidemiology, Karger1997
  • Location and severity of UVB irradiation damage in the rat lens, KOJIMA Masami, Japanese Jornal of Ophthalmology1997
  • Localization of cortical cataracts examined through photographic images, KOJIMA Masami, Developments in Ophthalmology, Cataract Epidemiology, Karger1997
  • Invitro UV-B effect on lens protein solutions, KOJIMA Masami, Ophthalmic Research1997
  • Experimentally induced steroid cataract in the rat : a Scanning electron microscopic study, KOJIMA Masami, Survey of Ophthalmology1997
  • Difference in the grading and type of lens opacification between both eyes examined in a population-Based survey in three areas of Japan, KOJIMA Masami, Developments in Ophthalmology, Cataract Epidemiology, Karger1997
  • Cataract formation : Its scenario and the present state, KOJIMA Masami1997
  • Aging changes of lens transparency in subjects with noncataractous eyes, KOJIMA Masami, Developments in Ophthalmology, Cataract Epidemiology, Karger1997
  • A new grading system for nuclear cataracts-An alternative to the Japanese cooperative cataract epidemiology study group's grading system, KOJIMA Masami, Developments in Ophthalmology, Cataract Epidemiology, Karger1997
  • A current UV-B-related cataract epidemiology study in Japan, KOJIMA Masami, Developments in Ophthalmology, Cataract Epidemiology, Karger1997
  • Visual acuity disturbance in subjects over 50 years of age in a population-based cataract survey, KOJIMA Masami, Ophthalmic Epidemiology1996
  • UV-B-induced cataract model in brown-norway rat eyes combined with preadministration of buthionine sulfoximine, KOJIMA Masami, Ophthalmic Research1996
  • Three-Dimensional volume visualization of the in vivo human ocular lens showing localization of the cataract, KOJIMA Masami, Ophthalmic Research1996
  • Inhibition of steroid-induced cataract in rat eyes by administration of vitamin-E ophthalmic solution, KOJIMA Masami, Ophthalmic Research1996
  • Effectiveness of a new sulfonylurea(Glime piride)in inhibiting cataract development in rats with experimentally induced diabetes, KOJIMA Masami, Folia Ophthalmologica Japonica1996
  • Distributional change of alpha-tocopherol in the rat lens with age, KOJIMA Masami, Ophthalmic Research1996
  • Composition of crystalline lens (Ion・ Protein), KOJIMA Masami, Practical Ophthalmology1996
  • A rabbit model for In Vivo evaluation of ultraviolet light absorption by UV-absorbing contact lenses, KOJIMA Masami, Jornal of Japan Contact Lens Society1996
  • A new steroid-induced cataract model in the rat : Long-term prednisolone applications with a minimum of X-irradiation, KOJIMA Masami, Ophthalmic Research1996
  • Ultraviolet radiation as a risk factor for cataracts, KOJIMA Masami, Journal of Kanazawa Medical University1995
  • Topographic distribution of prednisolone in the lens after organ culture, KOJIMA Masami, Ophthalmic research1995
  • Topical flucorazale : High penetration without corneal Toxicity, KOJIMA Masami, Ocular Toxicology1995
  • Protection against exposure to ultraviolet radiation, KOJIMA Masami, INTERSUN -A global UV project-, World Health Organization1995
  • Population based cataract epidemiology surveys utilizing a photo-documentation system, KOJIMA Masami, Documenta Ophthalmologica1995
  • Morphological and biochemical changes in lenses of guinea pigs after vitamin C deficient and UV-B radiation, KOJIMA Masami, Ophthalmic research1995
  • Influence of ultraviolet irradiation for the eye, KOJIMA Masami, Creabeaux1995
  • In vivo morphological changes in rat lenses induced by the administration of Prednisolone after subliminal X-irradiation, KOJIMA Masami, Ophthalmic research1995
  • Drug distribution studies in single lens layers through the application of a sectioning technique, KOJIMA Masami, Ocular Toxicology1995
  • Cataract Epidemiology Survey in the Three Climatically Different Areas in Japan -Prevalence of Cataracts and Types of Lens Opacification-, KOJIMA Masami, Journal of Japanese Ophthalmological Society1995
  • Aging changs of the eye, KOJIMA Masami, Current Encyclopedia of Ophthalmology1995
  • A mild progression type of naphthalene-induced cataract in brown-norway rats, KOJIMA Masami, Ophthalmic Research1995
  • Anterior eye segment images of common marmosets obtained through Scheimpflug Photography, KOJIMA Masami, Ophthalmic research1994
  • Analysis of crystalline lens coloration using a black and white charge-coupled device camera, KOJIMA Masami, German Jornal Ophthalmology1994
  • Study of local distribution of aldose reductase inhibitor (AL-04114), KOJIMA Masami, Journal of the eye1993
  • Studies of experimental cataract using regional lens analysis, KOJIMA Masami, The journal of the Japanese Society for Cataract Research1993
  • Reinvestigation of streptozotocin induced diabetic cataract as a standard experimental model, KOJIMA Masami, Journal of Japanese Ophthalmological Society1993
  • Localization of aldose reductase inhibitor (AL-04114) in Naphthalene induced cataract in rats, KOJIMA Masami, Journal of the eye1993
  • Lens changes in patients under longterm DMSO treatment, KOJIMA Masami, Japanese Journal of Clinical Ophthalmology1993
  • Intraocular penetration of Fluconazole after topical administration, KOJIMA Masami, Journal of Eye1993
  • Experimental models, KOJIMA Masami, Current Encyclopedia of Ophthalmology1993
  • Effect of topical fluconazole instillation on the rabbit eye, KOJIMA Masami, Journal of the eye1993
  • Differences in naphthalene cataract formation between albino and pigmented rat eye, KOJIMA Masami, Ophthalmic Research1993
  • Application of a new Scheimpflug camera (EAS-1000) to animal cataract models, KOJIMA Masami, Ophthalmic Research1992
  • Enzymatic distribution patterns of rat lenses and the changes that occur during naphthalene cataract development, KOJIMA Masami, Ophthalmic Research1992
  • Enzymatic distribution patterns of rat lenses and the changes that occur during Naphthalene cataract development, KOJIMA Masami, Ophthalmic Research1992
  • A new approach to the drug penetration study, KOJIMA Masami, Lens and eye toxicity research1992
  • Regional enzymatic analysis of UV-B and Streptozotocin induced diabetic cataract lens, KOJIMA Masami, Lens and Eye Toxicity Research1990
  • Investigations on the presence of 3-hydroxy-3-methylglutaryl coenzyme A reductase (HMG-CoA-reductase, EC in lenses . . . . . . . ., KOJIMA Masami, Lens and Eye Toxicity Research1990
  • Imaging characteristics of three cameras using the Scheimpflug principle, KOJIMA Masami, Ophthalmic Research1990
  • A study on the image analyzing methods for experimental animal cataract, KOJIMA Masami1990
  • Development and aging of the lens, KOJIMA Masami1989
  • The relationship between Capsular Shagreen" and lens epithelium", KOJIMA Masami1988
  • The efficacy of topically administered aldose reductase inhibitor on diabetic rats, KOJIMA Masami, Lens Research1988
  • The change of lens epithelium on diabetic rats and aging rats, KOJIMA Masami1988
  • The intraocular penetration of ARI (M-79175) in rabbit eyes, KOJIMA Masami1987
  • Creating a Stable Short-term Housing Environment for Rabbits in a Cargo Van, Takafumi Tasaki, Masami Kojima, Yukihisa Suzuki, Yoshinori Tatematsu, Hiroshi Sasaki, Journal of American Association for Laboratory Animal Science58:456-461Jul. 2019
  • Ocular Response to Millimeter Wave Exposure Under Different Levels of Humidity, Masami Kojima, Cheng-Yu Tsai, Yukihisa Suzuki, Kensuke Sasaki, Takafumi Tasaki, Masao Taki, Soichi Watanabe, Hiroshi Sasaki, Journal of Infrared, Millimeter, and Terahertz Waves40:574-584May. 2019

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