IWAWAKI Takao

FacultyDepartment of Life Sciences
PositionProfessor

Researcher Profile & Settings

Research

    Overview of research:
    Physiological and pathological function of cellular stress response

Degree

  • Ph. D

Association Memberships

  • Aug. 2000THE MOLECULAR BIOLOGY SOCIETY OF JAPAN
  • Feb. 2001JAPAN SOCIETY FOR CELL BIOLOGY
  • Aug. 2008The Biomedical Society for Stress Response
  • Apr. 2012Japanese Society of Fatigue Science
  • Dec. 2017Japanese Association for Laboratory Animal Science

Research Activities

Published Papers

  • Stabilization of cytokine mRNAs in iNKT cells requires the serine-threonine kinase IRE1alpha, Govindarajan S, Gaublomme D, Van der Cruyssen R, Verheugen E, Van Gassen S, Saeys Y, Tavernier S, Iwawaki T, Bloch Y, Savvides SN, Lambrecht BN, Janssens S, Elewaut D, Drennan MB, Nat Commun9:53402018
  • IRE1α governs cytoskeleton remodelling and cell migration through a direct interaction with filamin A, Urra H, Henriquez DR, Cánovas J, Villarroel-Campos D, Carreras-Sureda A, Pulgar E, Molina E, Hazari YM, Limia CM, Alvarez-Rojas S, Figueroa R, Vidal RL, Rodriguez DA, Rivera CA, Court FA, Couve A, Qi L, Chevet E, Akai R, Iwawaki T, Concha ML, Glavic Á, Gonzalez-Billault C, Hetz C, Nat Cell Biol20:942-9532018
  • Botulinum toxin B suppresses the pressure ulcer formation in cutaneous ischemia-reperfusion injury mouse model: Possible regulation of oxidative and endoplasmic reticulum stress, Sekiguchi A, Motegi SI, Uchiyama A, Uehara A, Fujiwara C, Yamazaki S, Perera B, Nakamura H, Ogino S, Yokoyama Y, Akai R, Iwawaki T, Ishikawa O, J Dermatol Sci90:144-1532018
  • Activation of host IRE1α-dependent signaling axis contributes the intracellular parasitism of Brucella melitensis, Pandey A, Lin F, Cabello AL, da Costa LF, Feng X, Feng HQ, Zhang MZ, Iwawaki T, Rice-Ficht A, Ficht TA, de Figueiredo P, Qin QM, Front Cell Infect Microbiol8:1032018
  • IRE1-XBP1 pathway regulates oxidative proinsulin folding in pancreatic β cells, Tsuchiya Y, Saito M, Kadokura H, Miyazaki JI, Tashiro F, Imagawa Y, Iwawaki T, Kohno K, J Cell Biol217:1287-13012018
  • ERα promotes murine hematopoietic regeneration through the Ire1α-mediated unfolded protein response, Chapple RH, Hu T, Tseng YJ, Liu L, Kitano A, Luu V, Hoegenauer KA, Iwawaki T, Li Q, Nakada D, Elife7:e311592018
  • Defective ATG16L1-mediated removal of IRE1α drives Crohn's disease-like ileitis, (Tschurtschenthaler M), Adolph TE, Ashcroft JW, Niederreiter L, Bharti R, Saveljeva S, Bhattacharyya J, Flak MB, Shih DQ, Fuhler GM, Parkes M, Kohno K, Iwawaki T, Janneke van der Woude C, Harding HP, Smith AM, Peppelenbosch MP, Targan SR, Ron D, Rosenstiel P, Blumberg RS, Kaser A, The Journal of Experimental Medicine214:401-4222017
  • Deletion of Inositol-Requiring Enzyme-1α in Podocytes Disrupts Glomerular Capillary Integrity and Autophagy, Kaufman DR, Papillon J, Larose L, Iwawaki T, Cybulsky AV, Molecular Biology of the Cell28:1636-16512017
  • IRE1 signaling exacerbates Alzheimer's disease pathogenesis, Duran-Aniotz C, Cornejo VH, Espinoza S, Ardiles ÁO, Medinas DB, Salazar C, Foley A, Gajardo I, Thielen P, Iwawaki T, Scheper W, Soto C, Palacios AG, Hoozemans JJ, Hetz C, Acta Neuropathologica134:489-5062017
  • IRE1α promotes viral infection by conferring resistance to apoptosis, Fink SL, Jayewickreme TR, Molony RD, Iwawaki T, Landis CS, Lindenbach BD, Iwasaki A, Science Signaling10:eaai78142017
  • Endoplasmic Reticulum Stress Sensor IRE1α Enhances IL-23 Expression by Human Dendritic Cells, Márquez S, Fernández JJ, Terán-Cabanillas E, Herrero C, Alonso S, Azogil A, Montero O, Iwawaki T, Cubillos-Ruiz JR, Fernández N, Crespo MS, Frontiers in Immunology8:6392017
  • Modulation of Unfolded Protein Response by Methylmercury, Hiraoka H, Nakahara K, Kaneko Y, Akiyama S, Okuda K, Iwawaki T, Fujimura M, Kumagai Y, Takasugi N, Uehara T, Biological and Pharmaceutical Bulletin40:1595-15982017
  • Nuclear factor (erythroid derived 2)-like 2 activation increases exercise endurance capacity via redox modulation in skeletal muscles, Oh S, Komine S, Warabi E, Akiyama K, Ishii A, Ishige K, Mizokami Y, Kuga K, Horie M, Miwa Y, Iwawaki T, Yamamoto M, Shoda J, Scientific Reports7:129022017
  • Protective effect of mesenchymal stem cells on the pressure ulcer formation by the regulation of oxidative and endoplasmic reticulum stress, (Motegi SI), Sekiguchi A, Uchiyama A, Uehara A, Fujiwara C, Yamazaki S, Perera B, Nakamura H, Ogino S, Yokoyama Y, Akai R, Iwawaki T, Ishikawa O, Scientific Reports7:171862017
  • Real-time in vivo imaging reveals localised Nrf2 stress responses associated with direct and metabolism-dependent drug toxicity, Forootan SS, Mutter FE, Kipar A, Iwawaki T, Francis B, Goldring CE, Park BK, Copple IM, Scientific Reports7:160842017
  • Regulated IRE1-dependent mRNA decay sets the threshold for dendritic cell survival, Tavernier SJ, Osorio F, Vandersarren L, Vetters J, Vanlangenakker N, Van Isterdael G, Vergote K, De Rycke R, Parthoens E, van de Laar L, Iwawaki T, Del Valle JR, Hu CA, Lambrecht BN, Janssens S, Nature Cell Biology19:698-7102017
  • Transgenic mouse model for imaging of ATF4 translational activation-related cellular stress responses in vivo, Iwawaki T, Akai R, Toyoshima T, Takeda N, Ishikawa T, Yamamura K, Scientific Reports7:462302017
  • From property of IL-1β to imaging of inflammation, Takao.Iwawaki, Japanese Journal of Clinical Immunology40:329-3362017
  • Necrotic Cell Sensor Clec4e Promotes a Pro-Atherogenic Macrophage Phenotype Through Activation of the Unfolded Protein Response., Clément M, Basatemur G, Masters L, Baker L, Bruneval P, Iwawaki T, Kneilling M, Yamasaki S, Goodall J, Mallat Z, Circulation134:1039-1051Sep. 2016
  • Crocetin protects ultraviolet A-induced oxidative stress and cell death in skin in vitro and in vivo., Ohba T, Ishisaka M, Tsujii S, Tsuruma K, Shimazawa M, Kubo K, Umigai N, Iwawaki T, Hara H, European Journal of Pharmacology789:244-253Jul. 2016
  • Saturated Fatty Acids Engage an IRE1α-Dependent Pathway to Activate the NLRP3 Inflammasome in Myeloid Cells., Robblee MM, Kim CC, Porter Abate J, Valdearcos M, Sandlund KL, Shenoy MK, Volmer R, Iwawaki T, Koliwad SK, Cell Reports14:2611-2623Mar. 2016
  • IRE1α is an endogenous substrate of endoplasmic-reticulum-associated degradation., Sun S, Shi G, Sha H, Ji Y, Han X, Shu X, Ma H, Inoue T, Gao B, Kim H, Bu P, Guber RD, Shen X, Lee AH, Iwawaki T, Paton AW, Paton JC, Fang D, Tsai B, Yates JR 3rd, Wu H, Kersten S, Long Q, Duhamel GE, Simpson KW, Qi L, Nature Cell Biology17:1546-1555Dec. 2015
  • Constitutive role of GADD34 and CReP in cancellation of phospho-eIF2α-dependent translational attenuation and insulin biosynthesis in pancreatic β cells., Akai R, Hosoda A, Yoshino M, Iwawaki T, Genes to Cells20:871-886Nov. 2015
  • 2-Phenyl-APB-144-Induced Retinal Pigment Epithelium Degeneration and Its Underlying Mechanisms., Hirai S, Kurashima H, Nakamura D, Komatsu T, Yasuda Y, Habashita-Obata S, Ichikawa S, Katsuta O, Iwawaki T, Kohno K, Journal of Ocular Pharmacology and Therapeutics31:570-584Nov. 2015
  • In Vivo Visualization of Endoplasmic Reticulum Stress in the Retina Using the ERAI Reporter Mouse., Alavi MV, Chiang WC, Kroeger H, Yasumura D, Matthes MT, Iwawaki T, LaVail MM, Gould DB, Lin JH, Investigative Ophthalmology & Visual Science56:6961-6970Oct. 2015
  • IRE1α/XBP1-mediated branch of the unfolded protein response regulates osteoclastogenesis., Tohmonda T, Yoda M, Iwawaki T, Matsumoto M, Nakamura M, Mikoshiba K, Toyama Y, Horiuchi K, The Journal of Clinical Investigation125:3269-3279Aug. 2015
  • Correlation between attenuation of protein disulfide isomerase activity through S-mercuration and neurotoxicity induced by methylmercury., Makino K, Okuda K, Sugino E, Nishiya T, Toyama T, Iwawaki T, Fujimura M, Kumagai Y, Uehara T, Neurotoxicity Research27:99-105Feb. 2015
  • Transgenic mouse model for imaging of interleukin-1β-related inflammation in vivo., Iwawaki T, Akai R, Oikawa D, Toyoshima T, Yoshino M, Suzuki M, Takeda N, Ishikawa TO, Kataoka Y, Yamamura K, Scientific Reports5:17205Nov. 2015
  • Regulation of the unfolded protein response via S-nitrosylation of sensors of endoplasmic reticulum stress., Nakato R, Ohkubo Y, Konishi A, Shibata M, Kaneko Y, Iwawaki T, Nakamura T, Lipton SA, Uehara T5:14812Oct. 2015
  • The co-chaperone and reductase ERdj5 facilitates rod opsin biogenesis and quality control., Athanasiou D, Bevilacqua D, Aguila M, McCulley C, Kanuga N, Iwawaki T, Chapple JP, Cheetham ME, Human Molecular Genetics23:6594-6606Dec. 2014
  • Evaluating experimental cerebral malaria using oxidative stress indicator OKD48 mice., Imai T, Iwawaki T, Akai R, Suzue K, Hirai M, Taniguchi T, Okada H, Hisaeda H, International Journal for Parasitology44:681-685Sep. 2014
  • Protection afforded by pre- or post-treatment with 4-phenylbutyrate against liver injury induced by acetaminophen overdose in mice., Shimizu D, Ishitsuka Y, Miyata K, Tomishima Y, Kondo Y, Irikura M, Iwawaki T, Oike Y, Irie T, Pharmacological Research87:26-41Sep. 2014
  • Temporal activation of Nrf2 in the penumbra and Nrf2 activator-mediated neuroprotection in ischemia-reperfusion injury., Takagi T, Kitashoji A, Iwawaki T, Tsuruma K, Shimazawa M, Yoshimura S, Iwama T, Hara H, Free Radical Biology & Medicine72:124-133Jul. 2014
  • Regulated IRE1-dependent decay participates in curtailing immunoglobulin secretion from plasma cells., Benhamron S, Hadar R, Iwawaki T, So JS, Lee AH, Tirosh B, European Journal of Immunology44:867-876Mar. 2014
  • The unfolded-protein-response sensor IRE-1α regulates the function of CD8α+ dendritic cells., Osorio F, Tavernier SJ, Hoffmann E, Saeys Y, Martens L, Vetters J, Delrue I, De Rycke R, Parthoens E, Pouliot P, Iwawaki T, Janssens S, Lambrecht BN, Nature Immunology15:248-257Mar. 2014
  • Comparative analysis of ER stress response into HIV protease inhibitors: lopinavir but not darunavir induces potent ER stress response via ROS/JNK pathway., Taura M, Kariya R, Kudo E, Goto H, Iwawaki T, Amano M, Suico MA, Kai H, Mitsuya H, Okada S, Free Radical Biology & Medicine65:778-788Dec. 2013
  • Paneth cells as a site of origin for intestinal inflammation., Adolph TE, Tomczak MF, Niederreiter L, Ko HJ, Böck J, Martinez-Naves E, Glickman JN, Tschurtschenthaler M, Hartwig J, Hosomi S, Flak MB, Cusick JL, Kohno K, Iwawaki T, Billmann-Born S, Raine T, Bharti R, Lucius R, Kweon MN, Marciniak SJ, Choi A, Hagen SJ, Schreiber S, Rosenstiel P, Kaser A, Blumberg RS, Nature503:272-276Nov. 2013
  • Identification of the redox partners of ERdj5/JPDI, a PDI family member, from an animal tissue., Kadokura H, Saito M, Tsuru A, Hosoda A, Iwawaki T, Inaba K, Kohno K, Biochemical and Biophysical Research Communications440:245-250Oct. 2013
  • ER stress transcription factor Xbp1 suppresses intestinal tumorigenesis and directs intestinal stem cells., Niederreiter L, Fritz TM, Adolph TE, Krismer AM, Offner FA, Tschurtschenthaler M, Flak MB, Hosomi S, Tomczak MF, Kaneider NC, Sarcevic E, Kempster SL, Raine T, Esser D, Rosenstiel P, Kohno K, Iwawaki T, Tilg H, Blumberg RS, Kaser A, The Journal of Experimental Medicine210:2041-2056Sep. 2013
  • Membrane lipid saturation activates IRE1α without inducing clustering., Kitai Y, Ariyama H, Kono N, Oikawa D, Iwawaki T, Arai H, Genes to Cells18:798-809Sep. 2013
  • CHOP is a critical regulator of acetaminophen-induced hepatotoxicity., Uzi D, Barda L, Scaiewicz V, Mills M, Mueller T, Gonzalez-Rodriguez A, Valverde AM, Iwawaki T, Nahmias Y, Xavier R, Chung RT, Tirosh B, Shibolet O, Journal of Hepatology59:495-503Sep. 2013
  • Microsomal triglyceride transfer protein inhibition induces endoplasmic reticulum stress and increases gene transcription via Ire1α/cJun to enhance plasma ALT/AST., Josekutty J, Iqbal J, Iwawaki T, Kohno K, Hussain MM, The Journal of Biological Chemistry288:14372-14383May 2013
  • The role of the unfolded protein response in diabetes mellitus., Iwawaki T, Oikawa D, Seminars in Immunopathology35:333-350May 2013
  • Positive contribution of IRE1α-XBP1 pathway to the expression of placental cathepsins., Oikawa D, Iwawaki T, Biochemical and Biophysical Research Communications433:426-431Apr. 2013
  • Endoplasmic reticulum stress signal impairs erythropoietin production: a role for ATF4., Chiang CK, Nangaku M, Tanaka T, Iwawaki T, Inagi R, American Journal of Physiology Cell Physiology304:C342-53Feb. 2013
  • Negative feedback by IRE1β optimizes mucin production in goblet cells., Tsuru A, Fujimoto N, Takahashi S, Saito M, Nakamura D, Iwano M, Iwawaki T, Kadokura H, Ron D, Kohno K, Proceedings of the National Academy of Sciences of the United States of America110:2864-2869Feb. 2013
  • Silencing of lipid metabolism genes through IRE1α-mediated mRNA decay lowers plasma lipids in mice., So JS, Hur KY, Tarrio M, Ruda V, Frank-Kamenetsky M, Fitzgerald K, Koteliansky V, Lichtman AH, Iwawaki T, Glimcher LH, Lee AH, Cell Metabolism16:487-499Oct. 2012
  • IRE1α activation protects mice against acetaminophen-induced hepatotoxicity., Hur KY, So JS, Ruda V, Frank-Kamenetsky M, Fitzgerald K, Koteliansky V, Iwawaki T, Glimcher LH, Lee AH, The Journal of Experimental Medicine209:307-318Feb. 2012
  • Identification of Toyocamycin, an agent cytotoxic for multiple myeloma cells, as a potent inhibitor of ER stress-induced XBP1 mRNA splicing., Ri M, Tashiro E, Oikawa D, Shinjo S, Tokuda M, Yokouchi Y, Narita T, Masaki A, Ito A, Ding J, Kusumoto S, Ishida T, Komatsu H, Shiotsu Y, Ueda R, Iwawaki T, Imoto M, Iida S, Blood Cancer Journal2:e79Jul. 2012
  • Direct association of unfolded proteins with mammalian ER stress sensor, IRE1β., Oikawa D, Kitamura A, Kinjo M, Iwawaki T, PloS One7:e512902012
  • A transgenic mouse model for monitoring oxidative stress., Oikawa D, Akai R, Tokuda M, Iwawaki T, Scientific Reports2:2292012
  • Function of yeast and amphioxus tRNA ligase in IRE1alpha-dependent XBP1 mRNA splicing., Iwawaki T, Tokuda M, Biochemical and Biophysical Research Communications413:527-531Oct. 2011
  • C/EBP homologous protein deficiency attenuates myocardial reperfusion injury by inhibiting myocardial apoptosis and inflammation., Miyazaki Y, Kaikita K, Endo M, Horio E, Miura M, Tsujita K, Hokimoto S, Yamamuro M, Iwawaki T, Gotoh T, Ogawa H, Oike Y, Arteriosclerosis, Thrombosis, and Vascular Biology31:1124-1132May 2011
  • A reporter for tracking the UPR in vivo reveals patterns of temporal and cellular stress during atherosclerotic progression., Thorp E, Iwawaki T, Miura M, Tabas I, Journal of Lipid Research52:1033-1038May 2011
  • The IRE1α-XBP1 pathway is essential for osteoblast differentiation through promoting transcription of Osterix., Tohmonda T, Miyauchi Y, Ghosh R, Yoda M, Uchikawa S, Takito J, Morioka H, Nakamura M, Iwawaki T, Chiba K, Toyama Y, Urano F, Horiuchi K, EMBO Reports12:451-457May 2011
  • Detection of ER stress in vivo by Raman spectroscopy., Hosoda A, Maruyama A, Oikawa D, Oshima Y, Komachi Y, Kanai G, Sato H, Iwawaki T, Biochemical and Biophysical Research Communications405:37-41Feb. 2011
  • Identification of a consensus element recognized and cleaved by IRE1 alpha., Oikawa D, Tokuda M, Hosoda A, Iwawaki T, Nucleic Acids Research38:6265-6273Oct. 2010
  • The endoplasmic reticulum stress-C/EBP homologous protein pathway-mediated apoptosis in macrophages contributes to the instability of atherosclerotic plaques., Tsukano H, Gotoh T, Endo M, Miyata K, Tazume H, Kadomatsu T, Yano M, Iwawaki T, Kohno K, Araki K, Mizuta H, Oike Y, Arteriosclerosis, Thrombosis, and Vascular Biology30:1925-1932Oct. 2010
  • Positive contribution of the IRE1alpha-XBP1 pathway to placental expression of CEA family genes., Oikawa D, Akai R, Iwawaki T, FEBS Letters584:1066-1070Mar. 2010
  • IRE1α disruption causes histological abnormality of exocrine tissues, increase of blood glucose level, and decrease of serum immunoglobulin level., Iwawaki T, Akai R, Kohno K, PloS One5:e13052Sep. 2010
  • Activation of mammalian IRE1alpha upon ER stress depends on dissociation of BiP rather than on direct interaction with unfolded proteins., Oikawa D, Kimata Y, Kohno K, Iwawaki T, Experimental Cell Research315:2496-2504Sep. 2009
  • Angiopoietin-like protein 2 promotes chronic adipose tissue inflammation and obesity-related systemic insulin resistance., Tabata M, Kadomatsu T, Fukuhara S, Miyata K, Ito Y, Endo M, Urano T, Zhu HJ, Tsukano H, Tazume H, Kaikita K, Miyashita K, Iwawaki T, Shimabukuro M, Sakaguchi K, Ito T, Nakagata N, Yamada T, Katagiri H, Kasuga M, Ando Y, Ogawa H, Mochizuki N, Itoh H, Suda T, Oike Y, Cell Metabolism10:178-188Sep. 2009
  • Positive contribution of ERdj5/JPDI to endoplasmic reticulum protein quality control in the salivary gland., Hosoda A, Tokuda M, Akai R, Kohno K, Iwawaki T, The Biochemical Journal425:117-125Sep. 2009
  • Function of IRE1 alpha in the placenta is essential for placental development and embryonic viability., Iwawaki T, Akai R, Yamanaka S, Kohno K, Proceedings of the National Academy of Sciences of the United States of America106:16657-16662Sep. 2009
  • Cotranslational targeting of XBP1 protein to the membrane promotes cytoplasmic splicing of its own mRNA., Yanagitani K, Imagawa Y, Iwawaki T, Hosoda A, Saito M, Kimata Y, Kohno K, Molecular Cell34:191-200Apr. 2009
  • Pioglitazone reduces ER stress in the liver: direct monitoring of in vivo ER stress using ER stress-activated indicator transgenic mice., Yoshiuchi K, Kaneto H, Matsuoka TA, Kasami R, Kohno K, Iwawaki T, Nakatani Y, Yamasaki Y, Shimomura I, Matsuhisa M, Endocrine Journal56:1103-11112009
  • An N-terminal 78 amino acid truncation of REIC/Dkk-3 effectively induces apoptosis., Abarzua F, Kashiwakura Y, Takaoka M, Watanabe M, Ochiai K, Sakaguchi M, Iwawaki T, Tanimoto R, Nasu Y, Huh NH, Kumon H, Biochemical and Biophysical Research Communications375:614-618Oct. 2008
  • Direct monitoring of in vivo ER stress during the development of insulin resistance with ER stress-activated indicator transgenic mice., Yoshiuchi K, Kaneto H, Matsuoka TA, Kohno K, Iwawaki T, Nakatani Y, Yamasaki Y, Hori M, Matsuhisa M, Biochemical and Biophysical Research Communications366:545-550Feb. 2008
  • Site-specific cleavage of CD59 mRNA by endoplasmic reticulum-localized ribonuclease, IRE1., Oikawa D, Tokuda M, Iwawaki T, Biochemical and Biophysical Research Communications360:122-127Aug. 2007
  • Analysis of the XBP1 splicing mechanism using endoplasmic reticulum stress-indicators., Iwawaki T, Akai R, Biochemical and Biophysical Research Communications350:709-715Nov. 2006
  • Regulation of human STARD4 gene expression under endoplasmic reticulum stress., Yamada S, Yamaguchi T, Hosoda A, Iwawaki T, Kohno K, Biochemical and Biophysical Research Communications343:1079-1085May 2006
  • A transgenic mouse model for monitoring endoplasmic reticulum stress., Iwawaki T, Akai R, Kohno K, Miura M, Nature Medicine10:98-102Jan. 2004
  • Liver regeneration in heparin-binding EGF-like growth factor transgenic mice after partial hepatectomy., Kiso S, Kawata S, Tamura S, Inui Y, Yoshida Y, Sawai Y, Umeki S, Ito N, Yamada A, Miyagawa J, Higashiyama S, Iwawaki T, Saito M, Taniguchi N, Matsuzawa Y, Kohno K, Gastroenterology124:701-707Mar. 2003
  • Diphtheria toxin receptor-mediated conditional and targeted cell ablation in transgenic mice., Saito M, Iwawaki T, Taya C, Yonekawa H, Noda M, Inui Y, Mekada E, Kimata Y, Tsuru A, Kohno K, Nature Biotechnology19:746-750Aug. 2001
  • Translational control by the ER transmembrane kinase/ribonuclease IRE1 under ER stress., Iwawaki T, Hosoda A, Okuda T, Kamigori Y, Nomura-Furuwatari C, Kimata Y, Tsuru A, Kohno K, Nature Cell Biology3:158-164Feb. 2001
  • Identification of a potential nurr1 response element that activates the tyrosine hydroxylase gene promoter in cultured cells., Iwawaki T, Kohno K, Kobayashi K, Biochemical and Biophysical Research Communications274:590-595Aug. 2000

Awards & Honors

  • Apr. 2012 Poster presentation award in UK-Japan Research Symposium on Molecular Mechanisms of Stress Response in Disease “High-sensitive in vivo detection of oxidative stress with OKD48 transgenic mice”
    Daisuke Oikawa, Ryoko Akai, Mio Tokuda, Takao Iwawaki
  • Jun. 2012 Presentation award in the 65th Annual Meeting of Society for Free Radical Research Japan “High-sensitive in-vivo detection of oxidative stress with OKD48 mice”
    Daisuke Oikawa, Ryoko Akai, Mio Tokuda, Takao Iwawaki
  • May 2011 Poster presentation award in the 2011 Cold Spring Harbor Asia Conference of New Advances in Optical Imaging of Live Cells & Organisms “A transgenic mouse model for monitoring oxidative stress”
    Daisuke Oikawa, Ryoko Akai, Mio Tokuda, Takao Iwawaki
  • Nov. 2011 SPI (Organizer) Award in the 6th IVIS User Forum “High-sensitive in vivo detection of oxidative stress with IVIS and new model mice”
    Ryoko Akai, Daisuke Oikawa, Mio Tokuda, Takao Iwawaki
  • Jan. 2004 Best poster presentation award in the annual meeting of Life of Proteins “Development of new system for monitoring endoplasmic reticulum stress”
    Takao Iwawaki, Ryoko Akai, Kenji Kohno, Masayuki Miura
  • Dec. 2003 Incentive award in the 4th Bio Business Competition Japan “Business strategy with new system for monitoring endoplasmic reticulum stress”
    Takao Iwawaki

Seeds

  • Genetic tools and model mice for visualization of endoplasmic reticulum stress
  • Genetic tools and model mice for visualization of oxidative stress
  • Genetic tools and model mice for visualization of inflammation
  • Genetic tools and model mice for visualization of integrated stress response


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