IWAWAKI Takao

FacultyDepartment of Life Sciences
PositionProfessor

Researcher Profile & Settings

Research

    Overview of research:
    Physiological and pathological function of cellular stress response

Special Field

  • Basic medicine
  • Cell biology
  • Laboratory animal science

Degree

  • Ph. D

Research Activities

Published Papers

  • The IRE1/XBP1 signaling axis promotes skeletal muscle regeneration through a cell non-autonomous mechanism, (Roy A), Tomaz da Silva M, Bhat R, Bohnert KR, Iwawaki T, Kumar A, Elife10:e73215Nov. 2021
  • Inhibition of skin fibrosis in systemic sclerosis by botulinum toxin B via the suppression of oxidative stress, (Baral H), Sekiguchi A, Uchiyama A, Nisaa Amalia S, Yamazaki S, Inoue Y, Yokoyama Y, Ogino S, Torii R, Hosoi M, Akai R, Iwawaki T, Ishikawa O, Motegi SI, J Dermatol48:1052-1061Jul. 2021
  • Hepatocyte-specific deletion of XBP1 sensitizes mice to liver injury through hyperactivation of IRE1α, (Duwaerts CC), Siao K, Soon RK Jr, Her C, Iwawaki T, Kohno K, Mattis AN, Maher JJ, Cell Death Differ28:1455-1465May 2021
  • Spatiotemporal analysis of the UPR transition induced by methylmercury in the mouse brain, (Hiraoka H), Nomura R, Takasugi N, Akai R, Iwawaki T, Kumagai Y, Fujimura M, Uehara T, Arch Toxicol95:1241-1250Apr. 2021
  • Protein quality control through endoplasmic reticulum-associated degradation maintains haematopoietic stem cell identity and niche interactions, Xu L, Liu X, Peng F, Zhang W, Zheng L, Ding Y, Gu T, Lv K, Wang J, Ortinau L, Hu T, Shi X, Shi G, Shang G, Sun S, Iwawaki T, Ji Y, Li W, Rosen JM, Zhang XH, Park D, Adoro S, Catic A, Tong W, Qi L, Nakada D, Chen X, Nat Cell Biol22:1162-11692020
  • Protective effect of dimethyl fumarate for the development of pressure ulcers after cutaneous ischemia-reperfusion injury, Inoue Y, Uchiyama A, Sekiguchi A, Yamazaki S, Fujiwara C, Yokoyama Y, Ogino S, Torii R, Hosoi M, Akai R, Iwawaki T, Ishikawa O, Motegi SI, Wound Repair Regen28:600-6082020
  • Transgenic mouse model exhibiting weak red fluorescence before and strong green fluorescenceafter Cre/loxP-mediated recombination, Akai R, Saito M, Kohno K, Iwawaki T, Exp Anim69:306-3182020
  • IRE1α regulates macrophage polarization, PD-L1 expression, and tumor survival, Batista A, Rodvold JJ, Xian S, Searles SC, Lew A, Iwawaki T, Almanza G, Waller TC, Lin J, Jepsen K, Carter H, Zanetti M, PLoS Biol18:e30006872020
  • AAV-mediated ERdj5 overexpression protects against P23H rhodopsin toxicity, Aguilà M, Bellingham J, Athanasiou D, Bevilacqua D, Duran Y, Maswood R, Parfitt DA, Iwawaki T, Spyrou G, Smith AJ, Ali RR, Cheetham ME, Hum Mol Genet29:1310-13182020
  • IRE1α Promotes Zika Virus Infection via XBP1, Kolpikova EP, Tronco AR, Hartigh ABD, Jackson KJ, Iwawaki T, Fink SL, Viruses12:2782020
  • Apelin/APJ signaling suppresses the pressure ulcer formation in cutaneous ischemia-reperfusion injury mouse model, Yamazaki S, Sekiguchi A, Uchiyama A, Fujiwara C, Inoue Y, Yokoyama Y, Ogino S, Torii R, Hosoi M, Akai R, Iwawaki T, Ishikawa O, Motegi SI, Sci Rep10:13492020
  • Role of IRE1α in podocyte proteostasis and mitochondrial health, Navarro-Betancourt JR, Papillon J, Guillemette J, Iwawaki T, Chung CF, Cybulsky AV, Cell Death Discov6:1282020
  • Danger-associated extracellular ATP counters MDSC therapeutic efficacy in acute GVHD, Koehn BH, Saha A, McDonald-Hyman C, Loschi M, Thangavelu G, Ma L, Zaiken M, Dysthe J, Krepps W, Panthera J, Hippen K, Jameson SC, Miller JS, Cooper MA, Farady CJ, Iwawaki T, Ting JP, Serody JS, Murphy WJ, Hill GR, Murray PJ, Bronte V, Munn DH, Zeiser R, Blazar BR, Blood134:1670-16822019
  • Inhibitory effect of kaempferol on skin fibrosis in systemic sclerosis by the suppression of oxidative stress, Sekiguchi A, Motegi SI, Fujiwara C, Yamazaki S, Inoue Y, Uchiyama A, Akai R, Iwawaki T, Ishikawa O, J Dermatol Sci96:8-172019
  • Zinc deficiency exacerbates pressure ulcers by increasing oxidative stress and ATP in the skin, Nakamura H, Sekiguchi A, Ogawa Y, Kawamura T, Akai R, Iwawaki T, Makiguchi T, Yokoo S, Ishikawa O, Motegi SI, J Dermatol Sci95:62-692019
  • MITOL prevents ER stress-induced apoptosis by IRE1α ubiquitylation at ER-mitochondria contact sites, Takeda K, Nagashima S, Shiiba I, Uda A, Tokuyama T, Ito N, Fukuda T, Matsushita N, Ishido S, Iwawaki T, Uehara T, Inatome R, Yanagi S, EMBO J38:e1009992019
  • IRE1α-XBP1 signaling in leukocytes controls prostaglandin biosynthesis and pain, Chopra S, Giovanelli P, Alvarado-Vazquez PA, Alonso S, Song M, Sandoval TA, Chae CS, Tan C, Fonseca MM, Gutierrez S, Jimenez L, Subbaramaiah K, Iwawaki T, Kingsley PJ, Marnett LJ, Kossenkov AV, Crespo MS, Dannenberg AJ, Glimcher LH, Romero-Sandoval EA, Cubillos-Ruiz JR, Science365:eaau64992019
  • Molecular Mechanism of Cellular Oxidative Stress Sensing by Keap1, Suzuki T, Muramatsu A, Saito R, Iso T, Shibata T, Kuwata K, Kawaguchi SI, Iwawaki T, Adachi S, Suda H, Morita M, Uchida K, Baird L, Yamamoto M, Cell Rep28:746-7582019
  • ERdj5 in Innate Immune Cells Is a Crucial Factor for the Mucosal Adjuvanticity of Cholera Toxin, Kim MS, Yi EJ, Kim YI, Kim SH, Jung YS, Kim SR, Iwawaki T, Ko HJ, Chang SY, Front Immunol10:12492019
  • Adaptive endoplasmic reticulum stress signalling via IRE1α-XBP1 preserves self-renewal of haematopoietic and pre-leukaemic stem cells, Liu L, Zhao M, Jin X, Ney G, Yang KB, Peng F, Cao J, Iwawaki T, Del Valle J, Chen X, Li Q, Nat Cell Biol21:328-3372019
  • Ablation of the Chaperone Protein ERdj5 Results in a Sjögren's Syndrome-Like Phenotype in Mice, Consistent With an Upregulated Unfolded Protein Response in Human Patients, Apostolou E, Moustardas P, Iwawaki T, Tzioufas AG, Spyrou G, Front Immunol10:5062019
  • IRE1α Activation in Bone Marrow-Derived Dendritic Cells Modulates Innate Recognition of Melanoma Cells and Favors CD8+ T Cell Priming, Medel B, Costoya C, Fernandez D, Pereda C, Lladser A, Sauma D, Pacheco R, Iwawaki T, Salazar-Onfray F, Osorio F, Front Immunol9:30502019
  • Salmonella exploits HLA-B27 and host unfolded protein responses to promote intracellular replication, Antoniou AN, Lenart I, Kriston-Vizi J, Iwawaki T, Turmaine M, McHugh K, Ali S, Blake N, Bowness P, Bajaj-Elliott M, Gould K, Nesbeth D, Powis SJ, Ann Rheum Dis78:74-822019
  • Stabilization of cytokine mRNAs in iNKT cells requires the serine-threonine kinase IRE1alpha, Govindarajan S, Gaublomme D, Van der Cruyssen R, Verheugen E, Van Gassen S, Saeys Y, Tavernier S, Iwawaki T, Bloch Y, Savvides SN, Lambrecht BN, Janssens S, Elewaut D, Drennan MB, Nat Commun9:53402018
  • IRE1α governs cytoskeleton remodelling and cell migration through a direct interaction with filamin A, Urra H, Henriquez DR, Cánovas J, Villarroel-Campos D, Carreras-Sureda A, Pulgar E, Molina E, Hazari YM, Limia CM, Alvarez-Rojas S, Figueroa R, Vidal RL, Rodriguez DA, Rivera CA, Court FA, Couve A, Qi L, Chevet E, Akai R, Iwawaki T, Concha ML, Glavic Á, Gonzalez-Billault C, Hetz C, Nat Cell Biol20:942-9532018
  • Botulinum toxin B suppresses the pressure ulcer formation in cutaneous ischemia-reperfusion injury mouse model: Possible regulation of oxidative and endoplasmic reticulum stress, Sekiguchi A, Motegi SI, Uchiyama A, Uehara A, Fujiwara C, Yamazaki S, Perera B, Nakamura H, Ogino S, Yokoyama Y, Akai R, Iwawaki T, Ishikawa O, J Dermatol Sci90:144-1532018
  • Activation of host IRE1α-dependent signaling axis contributes the intracellular parasitism of Brucella melitensis, Pandey A, Lin F, Cabello AL, da Costa LF, Feng X, Feng HQ, Zhang MZ, Iwawaki T, Rice-Ficht A, Ficht TA, de Figueiredo P, Qin QM, Front Cell Infect Microbiol8:1032018
  • ERα promotes murine hematopoietic regeneration through the Ire1α-mediated unfolded protein response, Chapple RH, Hu T, Tseng YJ, Liu L, Kitano A, Luu V, Hoegenauer KA, Iwawaki T, Li Q, Nakada D, Elife7:e311592018
  • IRE1-XBP1 pathway regulates oxidative proinsulin folding in pancreatic β cells., Tsuchiya Y, Saito M, Kadokura H, Miyazaki JI, Tashiro F, Imagawa Y, Iwawaki T, Kohno K217:1287-13012018
  • Defective ATG16L1-mediated removal of IRE1α drives Crohn's disease-like ileitis, (Tschurtschenthaler M), Adolph TE, Ashcroft JW, Niederreiter L, Bharti R, Saveljeva S, Bhattacharyya J, Flak MB, Shih DQ, Fuhler GM, Parkes M, Kohno K, Iwawaki T, Janneke van der Woude C, Harding HP, Smith AM, Peppelenbosch MP, Targan SR, Ron D, Rosenstiel P, Blumberg RS, Kaser A, J Exp Med214:401-4222017
  • Deletion of Inositol-Requiring Enzyme-1α in Podocytes Disrupts Glomerular Capillary Integrity and Autophagy, Kaufman DR, Papillon J, Larose L, Iwawaki T, Cybulsky AV, Mol Biol Cell28:1636-16512017
  • IRE1 signaling exacerbates Alzheimer's disease pathogenesis, Duran-Aniotz C, Cornejo VH, Espinoza S, Ardiles ÁO, Medinas DB, Salazar C, Foley A, Gajardo I, Thielen P, Iwawaki T, Scheper W, Soto C, Palacios AG, Hoozemans JJ, Hetz C, Acta Neuropathol134:489-5062017
  • IRE1α promotes viral infection by conferring resistance to apoptosis, Fink SL, Jayewickreme TR, Molony RD, Iwawaki T, Landis CS, Lindenbach BD, Iwasaki A, Sci Signal10:eaai78142017
  • Endoplasmic Reticulum Stress Sensor IRE1α Enhances IL-23 Expression by Human Dendritic Cells, Márquez S, Fernández JJ, Terán-Cabanillas E, Herrero C, Alonso S, Azogil A, Montero O, Iwawaki T, Cubillos-Ruiz JR, Fernández N, Crespo MS, Front Immunol8:6392017
  • Modulation of Unfolded Protein Response by Methylmercury, Hiraoka H, Nakahara K, Kaneko Y, Akiyama S, Okuda K, Iwawaki T, Fujimura M, Kumagai Y, Takasugi N, Uehara T, Biol Pharm Bull40:1595-15982017
  • Nuclear factor (erythroid derived 2)-like 2 activation increases exercise endurance capacity via redox modulation in skeletal muscles, Oh S, Komine S, Warabi E, Akiyama K, Ishii A, Ishige K, Mizokami Y, Kuga K, Horie M, Miwa Y, Iwawaki T, Yamamoto M, Shoda J, Sci Rep7:129022017
  • Protective effect of mesenchymal stem cells on the pressure ulcer formation by the regulation of oxidative and endoplasmic reticulum stress, (Motegi SI), Sekiguchi A, Uchiyama A, Uehara A, Fujiwara C, Yamazaki S, Perera B, Nakamura H, Ogino S, Yokoyama Y, Akai R, Iwawaki T, Ishikawa O, Sci Rep7:171862017
  • Real-time in vivo imaging reveals localised Nrf2 stress responses associated with direct and metabolism-dependent drug toxicity, Forootan SS, Mutter FE, Kipar A, Iwawaki T, Francis B, Goldring CE, Park BK, Copple IM, Sci Rep7:160842017
  • Regulated IRE1-dependent mRNA decay sets the threshold for dendritic cell survival, Tavernier SJ, Osorio F, Vandersarren L, Vetters J, Vanlangenakker N, Van Isterdael G, Vergote K, De Rycke R, Parthoens E, van de Laar L, Iwawaki T, Del Valle JR, Hu CA, Lambrecht BN, Janssens S, Nat Cell Biol19:698-7102017
  • Transgenic mouse model for imaging of ATF4 translational activation-related cellular stress responses in vivo, Iwawaki T, Akai R, Toyoshima T, Takeda N, Ishikawa T, Yamamura K, Sci Rep7:462302017
  • From property of IL-1β to imaging of inflammation, Takao.Iwawaki, Japanese Journal of Clinical Immunology40:329-3362017
  • Necrotic Cell Sensor Clec4e Promotes a Pro-Atherogenic Macrophage Phenotype Through Activation of the Unfolded Protein Response., Clément M, Basatemur G, Masters L, Baker L, Bruneval P, Iwawaki T, Kneilling M, Yamasaki S, Goodall J, Mallat Z, Circulation134:1039-10512016
  • Crocetin protects ultraviolet A-induced oxidative stress and cell death in skin in vitro and in vivo., Ohba T, Ishisaka M, Tsujii S, Tsuruma K, Shimazawa M, Kubo K, Umigai N, Iwawaki T, Hara H, Eur J Pharmacol789:244-2532016
  • Saturated Fatty Acids Engage an IRE1α-Dependent Pathway to Activate the NLRP3 Inflammasome in Myeloid Cells., Robblee MM, Kim CC, Porter Abate J, Valdearcos M, Sandlund KL, Shenoy MK, Volmer R, Iwawaki T, Koliwad SK, Cell Rep14:2611-26232016
  • IRE1α is an endogenous substrate of endoplasmic-reticulum-associated degradation., Sun S, Shi G, Sha H, Ji Y, Han X, Shu X, Ma H, Inoue T, Gao B, Kim H, Bu P, Guber RD, Shen X, Lee AH, Iwawaki T, Paton AW, Paton JC, Fang D, Tsai B, Yates JR 3rd, Wu H, Kersten S, Long Q, Duhamel GE, Simpson KW, Qi L, Nat Cell Biol17:1546-15552015
  • Constitutive role of GADD34 and CReP in cancellation of phospho-eIF2α-dependent translational attenuation and insulin biosynthesis in pancreatic β cells., Akai R, Hosoda A, Yoshino M, Iwawaki T, Genes Cells20:871-8862015
  • 2-Phenyl-APB-144-Induced Retinal Pigment Epithelium Degeneration and Its Underlying Mechanisms., Hirai S, Kurashima H, Nakamura D, Komatsu T, Yasuda Y, Habashita-Obata S, Ichikawa S, Katsuta O, Iwawaki T, Kohno K, J Ocul Pharmacol Ther31:570-5842015
  • Transgenic mouse model for imaging of interleukin-1β-related inflammation in vivo., Iwawaki T, Akai R, Oikawa D, Toyoshima T, Yoshino M, Suzuki M, Takeda N, Ishikawa TO, Kataoka Y, Yamamura K, Sci Rep5:172052015
  • In Vivo Visualization of Endoplasmic Reticulum Stress in the Retina Using the ERAI Reporter Mouse., Alavi MV, Chiang WC, Kroeger H, Yasumura D, Matthes MT, Iwawaki T, LaVail MM, Gould DB, Lin JH, Invest Ophthalmol Vis Sci56:6961-69702015
  • Regulation of the unfolded protein response via S-nitrosylation of sensors of endoplasmic reticulum stress., Nakato R, Ohkubo Y, Konishi A, Shibata M, Kaneko Y, Iwawaki T, Nakamura T, Lipton SA, Uehara T, Sci Rep5:148122015
  • IRE1α/XBP1-mediated branch of the unfolded protein response regulates osteoclastogenesis., Tohmonda T, Yoda M, Iwawaki T, Matsumoto M, Nakamura M, Mikoshiba K, Toyama Y, Horiuchi K, J Clin Invest125:3269-32792015
  • Correlation between attenuation of protein disulfide isomerase activity through S-mercuration and neurotoxicity induced by methylmercury., Makino K, Okuda K, Sugino E, Nishiya T, Toyama T, Iwawaki T, Fujimura M, Kumagai Y, Uehara T, Neurotox Res27:99-1052015
  • The co-chaperone and reductase ERdj5 facilitates rod opsin biogenesis and quality control., Athanasiou D, Bevilacqua D, Aguila M, McCulley C, Kanuga N, Iwawaki T, Chapple JP, Cheetham ME, Hum Mol Genet23:6594-66062014
  • Evaluating experimental cerebral malaria using oxidative stress indicator OKD48 mice., Imai T, Iwawaki T, Akai R, Suzue K, Hirai M, Taniguchi T, Okada H, Hisaeda H, Int J Parasitol44:681-6852014
  • Protection afforded by pre- or post-treatment with 4-phenylbutyrate against liver injury induced by acetaminophen overdose in mice., Shimizu D, Ishitsuka Y, Miyata K, Tomishima Y, Kondo Y, Irikura M, Iwawaki T, Oike Y, Irie T, Pharmacol Res87:26-412014
  • Temporal activation of Nrf2 in the penumbra and Nrf2 activator-mediated neuroprotection in ischemia-reperfusion injury., Takagi T, Kitashoji A, Iwawaki T, Tsuruma K, Shimazawa M, Yoshimura S, Iwama T, Hara H, Free Radic Biol Med72:124-1332014
  • Regulated IRE1-dependent decay participates in curtailing immunoglobulin secretion from plasma cells., Benhamron S, Hadar R, Iwawaki T, So JS, Lee AH, Tirosh B, Eur J Immunol44:867-8762014
  • The unfolded-protein-response sensor IRE-1α regulates the function of CD8α+ dendritic cells., Osorio F, Tavernier SJ, Hoffmann E, Saeys Y, Martens L, Vetters J, Delrue I, De Rycke R, Parthoens E, Pouliot P, Iwawaki T, Janssens S, Lambrecht BN, Nat Immunol15:248-2572014
  • Comparative analysis of ER stress response into HIV protease inhibitors: lopinavir but not darunavir induces potent ER stress response via ROS/JNK pathway., Taura M, Kariya R, Kudo E, Goto H, Iwawaki T, Amano M, Suico MA, Kai H, Mitsuya H, Okada S, Free Radic Biol Med65:778-7882013
  • Paneth cells as a site of origin for intestinal inflammation., Adolph TE, Tomczak MF, Niederreiter L, Ko HJ, Böck J, Martinez-Naves E, Glickman JN, Tschurtschenthaler M, Hartwig J, Hosomi S, Flak MB, Cusick JL, Kohno K, Iwawaki T, Billmann-Born S, Raine T, Bharti R, Lucius R, Kweon MN, Marciniak SJ, Choi A, Hagen SJ, Schreiber S, Rosenstiel P, Kaser A, Blumberg RS, Nature503:272-2762013
  • Identification of the redox partners of ERdj5/JPDI, a PDI family member, from an animal tissue., Kadokura H, Saito M, Tsuru A, Hosoda A, Iwawaki T, Inaba K, Kohno K, Biochem Biophys Res Commun440:245-2502013
  • ER stress transcription factor Xbp1 suppresses intestinal tumorigenesis and directs intestinal stem cells., Niederreiter L, Fritz TM, Adolph TE, Krismer AM, Offner FA, Tschurtschenthaler M, Flak MB, Hosomi S, Tomczak MF, Kaneider NC, Sarcevic E, Kempster SL, Raine T, Esser D, Rosenstiel P, Kohno K, Iwawaki T, Tilg H, Blumberg RS, Kaser A, J Exp Med210:2041-20562013
  • Membrane lipid saturation activates IRE1α without inducing clustering., Kitai Y, Ariyama H, Kono N, Oikawa D, Iwawaki T, Arai H, Genes Cells18:798-8092013
  • CHOP is a critical regulator of acetaminophen-induced hepatotoxicity., Uzi D, Barda L, Scaiewicz V, Mills M, Mueller T, Gonzalez-Rodriguez A, Valverde AM, Iwawaki T, Nahmias Y, Xavier R, Chung RT, Tirosh B, Shibolet O, J Hepatol59:495-5032013
  • Microsomal triglyceride transfer protein inhibition induces endoplasmic reticulum stress and increases gene transcription via Ire1α/cJun to enhance plasma ALT/AST., Josekutty J, Iqbal J, Iwawaki T, Kohno K, Hussain MM, J Biol Chem288:14372-143832013
  • The role of the unfolded protein response in diabetes mellitus., Iwawaki T, Oikawa D, Semin Immunopathol35:333-3502013
  • Positive contribution of IRE1α-XBP1 pathway to the expression of placental cathepsins., Oikawa D, Iwawaki T, Biochem Biophys Res Commun433:426-4312013
  • Endoplasmic reticulum stress signal impairs erythropoietin production: a role for ATF4., Chiang CK, Nangaku M, Tanaka T, Iwawaki T, Inagi R, Am J Physiol Cell Physiol304:C342-532013
  • Negative feedback by IRE1β optimizes mucin production in goblet cells., Tsuru A, Fujimoto N, Takahashi S, Saito M, Nakamura D, Iwano M, Iwawaki T, Kadokura H, Ron D, Kohno K, Proc Natl Acad Sci USA110:2864-28692013
  • Silencing of lipid metabolism genes through IRE1α-mediated mRNA decay lowers plasma lipids in mice., So JS, Hur KY, Tarrio M, Ruda V, Frank-Kamenetsky M, Fitzgerald K, Koteliansky V, Lichtman AH, Iwawaki T, Glimcher LH, Lee AH, Cell Metab16:487-4992012
  • Identification of Toyocamycin, an agent cytotoxic for multiple myeloma cells, as a potent inhibitor of ER stress-induced XBP1 mRNA splicing., Ri M, Tashiro E, Oikawa D, Shinjo S, Tokuda M, Yokouchi Y, Narita T, Masaki A, Ito A, Ding J, Kusumoto S, Ishida T, Komatsu H, Shiotsu Y, Ueda R, Iwawaki T, Imoto M, Iida S, Blood Cancer J2:e792012
  • IRE1α activation protects mice against acetaminophen-induced hepatotoxicity., Hur KY, So JS, Ruda V, Frank-Kamenetsky M, Fitzgerald K, Koteliansky V, Iwawaki T, Glimcher LH, Lee AH, J Exp Med209:307-3182012
  • Direct association of unfolded proteins with mammalian ER stress sensor, IRE1β., Oikawa D, Kitamura A, Kinjo M, Iwawaki T, PLoS ONE7:e512902012
  • A transgenic mouse model for monitoring oxidative stress., Oikawa D, Akai R, Tokuda M, Iwawaki T, Sci Rep2:2292012
  • Function of yeast and amphioxus tRNA ligase in IRE1alpha-dependent XBP1 mRNA splicing., Iwawaki T, Tokuda M, Biochem Biophys Res Commun413:527-5312011
  • C/EBP homologous protein deficiency attenuates myocardial reperfusion injury by inhibiting myocardial apoptosis and inflammation., Miyazaki Y, Kaikita K, Endo M, Horio E, Miura M, Tsujita K, Hokimoto S, Yamamuro M, Iwawaki T, Gotoh T, Ogawa H, Oike Y, Arterioscler Thromb Vasc Biol31:1124-11322011
  • A reporter for tracking the UPR in vivo reveals patterns of temporal and cellular stress during atherosclerotic progression., Thorp E, Iwawaki T, Miura M, Tabas I, J Lipid Res52:1033-10382011
  • The IRE1α-XBP1 pathway is essential for osteoblast differentiation through promoting transcription of Osterix., Tohmonda T, Miyauchi Y, Ghosh R, Yoda M, Uchikawa S, Takito J, Morioka H, Nakamura M, Iwawaki T, Chiba K, Toyama Y, Urano F, Horiuchi K, EMBO Rep12:451-4572011
  • Detection of ER stress in vivo by Raman spectroscopy., Hosoda A, Maruyama A, Oikawa D, Oshima Y, Komachi Y, Kanai G, Sato H, Iwawaki T, Biochem Biophys Res Commun405:37-412011
  • Identification of a consensus element recognized and cleaved by IRE1 alpha., Oikawa D, Tokuda M, Hosoda A, Iwawaki T, Nucleic Acid Res38:6265-62732010
  • The endoplasmic reticulum stress-C/EBP homologous protein pathway-mediated apoptosis in macrophages contributes to the instability of atherosclerotic plaques., Tsukano H, Gotoh T, Endo M, Miyata K, Tazume H, Kadomatsu T, Yano M, Iwawaki T, Kohno K, Araki K, Mizuta H, Oike Y, Arterioscler Thromb Vasc Biol30:1925-19322010
  • IRE1α disruption causes histological abnormality of exocrine tissues, increase of blood glucose level, and decrease of serum immunoglobulin level., Iwawaki T, Akai R, Kohno K, PLoS ONE5:e130522010
  • Positive contribution of the IRE1alpha-XBP1 pathway to placental expression of CEA family genes., Oikawa D, Akai R, Iwawaki T, FEBS Lett584:1066-10702010
  • Activation of mammalian IRE1alpha upon ER stress depends on dissociation of BiP rather than on direct interaction with unfolded proteins., Oikawa D, Kimata Y, Kohno K, Iwawaki T, Exp Cell Res315:2496-25042009
  • Angiopoietin-like protein 2 promotes chronic adipose tissue inflammation and obesity-related systemic insulin resistance., Tabata M, Kadomatsu T, Fukuhara S, Miyata K, Ito Y, Endo M, Urano T, Zhu HJ, Tsukano H, Tazume H, Kaikita K, Miyashita K, Iwawaki T, Shimabukuro M, Sakaguchi K, Ito T, Nakagata N, Yamada T, Katagiri H, Kasuga M, Ando Y, Ogawa H, Mochizuki N, Itoh H, Suda T, Oike Y, Cell Metab10:178-1882009
  • Positive contribution of ERdj5/JPDI to endoplasmic reticulum protein quality control in the salivary gland., Hosoda A, Tokuda M, Akai R, Kohno K, Iwawaki T, Biochem J425:117-1252009
  • Function of IRE1 alpha in the placenta is essential for placental development and embryonic viability., Iwawaki T, Akai R, Yamanaka S, Kohno K, Proc Natl Acad Sci USA106:16657-166622009
  • Cotranslational targeting of XBP1 protein to the membrane promotes cytoplasmic splicing of its own mRNA., Yanagitani K, Imagawa Y, Iwawaki T, Hosoda A, Saito M, Kimata Y, Kohno K, Mol Cell34:191-2002009
  • Pioglitazone reduces ER stress in the liver: direct monitoring of in vivo ER stress using ER stress-activated indicator transgenic mice., Yoshiuchi K, Kaneto H, Matsuoka TA, Kasami R, Kohno K, Iwawaki T, Nakatani Y, Yamasaki Y, Shimomura I, Matsuhisa M, Endocr J56:1103-11112009
  • An N-terminal 78 amino acid truncation of REIC/Dkk-3 effectively induces apoptosis., Abarzua F, Kashiwakura Y, Takaoka M, Watanabe M, Ochiai K, Sakaguchi M, Iwawaki T, Tanimoto R, Nasu Y, Huh NH, Kumon H, Biochem Biophys Res Commun375:614-6182008
  • Direct monitoring of in vivo ER stress during the development of insulin resistance with ER stress-activated indicator transgenic mice., Yoshiuchi K, Kaneto H, Matsuoka TA, Kohno K, Iwawaki T, Nakatani Y, Yamasaki Y, Hori M, Matsuhisa M, Biochem Biophys Res Commun366:545-5502008
  • Site-specific cleavage of CD59 mRNA by endoplasmic reticulum-localized ribonuclease, IRE1., Oikawa D, Tokuda M, Iwawaki T, Biochem Biophys Res Commun360:122-1272007
  • Analysis of the XBP1 splicing mechanism using endoplasmic reticulum stress-indicators., Iwawaki T, Akai R, Biochem Biophys Res Commun350:709-7152006
  • Regulation of human STARD4 gene expression under endoplasmic reticulum stress., Yamada S, Yamaguchi T, Hosoda A, Iwawaki T, Kohno K, Biochem Biophys Res Commun343:1079-10852006
  • A transgenic mouse model for monitoring endoplasmic reticulum stress., Iwawaki T, Akai R, Kohno K, Miura M, Nat Med10:98-1022004
  • Liver regeneration in heparin-binding EGF-like growth factor transgenic mice after partial hepatectomy., Kiso S, Kawata S, Tamura S, Inui Y, Yoshida Y, Sawai Y, Umeki S, Ito N, Yamada A, Miyagawa J, Higashiyama S, Iwawaki T, Saito M, Taniguchi N, Matsuzawa Y, Kohno K, Gastroenterology124:701-7072003
  • Diphtheria toxin receptor-mediated conditional and targeted cell ablation in transgenic mice., Saito M, Iwawaki T, Taya C, Yonekawa H, Noda M, Inui Y, Mekada E, Kimata Y, Tsuru A, Kohno K, Nat Biotechnol19:746-7502001
  • Translational control by the ER transmembrane kinase/ribonuclease IRE1 under ER stress., Iwawaki T, Hosoda A, Okuda T, Kamigori Y, Nomura-Furuwatari C, Kimata Y, Tsuru A, Kohno K, Nat Cell Biol3:158-1642001
  • Identification of a potential nurr1 response element that activates the tyrosine hydroxylase gene promoter in cultured cells., Iwawaki T, Kohno K, Kobayashi K, Biochem Biophys Res Commun274:590-5952000

Awards & Honors

  • Dec. 2003 Incentive award in the 4th Bio Business Competition Japan “Business strategy with new system for monitoring endoplasmic reticulum stress”
    Takao Iwawaki

Seeds

  • Genetic tools and model mice for visualization of endoplasmic reticulum stress
  • Genetic tools and model mice for visualization of oxidative stress
  • Genetic tools and model mice for visualization of inflammation
  • Genetic tools and model mice for visualization of integrated stress response


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