Japanese

KAWANAMI Takafumi

■Faculty	Department of Hematology and Immunology
■Position	Senior Assistant Professor

Researcher Profile & Settings

Research

Overview of research:

Stem cell therapy is expected to be the promising method for the compensation of lost organs. We identified side population cells (SP cells), which are highly enriched for stem cell activity, in cultured salivary epithelial cells to apply them for the cell therapy of hypofunction in that damaged glands.

Degree

Doctor(Engineering)

Association Memberships

Japanese Society of Rhematology

Academic & Professional Experience

2002Kanazawa Medical University, Faculty of Medicine Research Associate

Research Activities

Published Papers

Impaired expression of innate immunity-related genes in IgG4-related disease: A possible mechanism in the pathogenesis of IgG4-RD, Takuji Nakamura, Tomomi Satoh-Nakamura, Akio Nakajima, Takafumi Kawanami, Tomoyuki Sakai, Yoshimasa Fujita, Haruka Iwao, Miyuki Miki, Yasufumi Masaki, Toshiro Okazaki, Yasuhito Ishigaki, Mitsuhiro Kawano, Kazunori Yamada, Shoko Matsui, Takako Saeki, Terumi Kamisawa, Motohisa Yamamoto, Hideaki Hamano, Tomoki Origuchi, Shintaro Hirata, Yoshiya Tanaka, Hiroto Tsuboi, Takayuki Sumida, Kazuichi Okazaki, Masao Tanaka, Tsutomu Chiba, Tsuneo Mimori, Hisanori Umehara, Modern Rheumatology, 30:551-557, May 2020
Osteosarcoma Manifesting Systemic Inflammation and Histological Features Mimicking Plasma Cell-type Castleman Disease, Shino Fujimoto, Tomoyuki Sakai, Hiroshi Kawabata, Nozomu Kurose, Sohsuke Yamada, Mariko Doai, Munetaka Matoba, Haruka Iwao-Kawanami, Takafumi Kawanami, Shuichi Mizuta, Toshihiro Fukushima, Hiroki Mizumaki, Masaki Yamaguchi, Yasufumi Masaki, Internal Medicine, 58:2555-2560, Sep. 2019
Is TAFRO syndrome a subtype of idiopathic multicentric Castleman disease?, Shino Fujimoto, Tomoyuki Sakai, Hiroshi Kawabata, Nozomu Kurose, Sohsuke Yamada, Kazue Takai, Sadao Aoki, Junya Kuroda, Makoto Ide, Keigo Setoguchi, Norifumi Tsukamoto, Haruka Iwao-Kawanami, Takafumi Kawanami, Shuichi Mizuta, Toshihiro Fukushima, Yasufumi Masaki, American Journal of Hematology, 94:975-983, Sep. 2019
Natural History and Predictors of Progression to Sjögren's Syndrome Among Participants of the Sjögren's International Collaborative Clinical Alliance Registry., Caroline H Shiboski, Alan N Baer, Stephen C Shiboski, Mi Lam, Stephen Challacombe, FDSRCS, FRCPath, FMedSci, Hector E Lanfranchi, Morten Schiødt, Penelope Shirlaw, Muthiah Srinivasan, Hisanori Umehara, Frederick B Vivino, Esen Akpek, Vatinee Bunya, Cristina F Vollenweider, John S Greenspan, Troy E Daniels, Lindsey A Criswell, and for the Sjögren’s International Collaborative Clinical Alliance (SICCA) Research Groups, Arthritis care & research., 70:284-294, Feb. 2018
The treatment strategy of IgG4-related disease - from the result of prospective clinical study -, Yasufumi.Masaki, Shino.Fujimoto, Haruka.Kawanami (Iwao), Tomoyuki.Sakai, Takafumi.Kawanami, Yopshimasa.Fujita, Hiroshi.Kawabata, Toshihiro.Fukushima, 29:140-146, Jun. 2017
A multicenter phase II prospective clinical trial of glucocorticoid for patients with untreated IgG4-related disease, Yasufumi.Masaki, shoko.Matsui, Takako.Saeki, Hiroto.Tsuboi, Shintaro.Hirata, Yasumori.Izumi, Taiichiro.Miyashita, Keita.Fujikawa, Hiroaki.Dobashi, Kentaro.Susaki, Hisanori.Morimoto, Kasutaka.Takagi, Mitsuhiro.Kawano,Tomoki.Origuchi, Yoko.Wada, Naoki.Takahashi, Masanobu.Horikashi, Hiroshi.Ogishima, Yasunori.Suzuki, Takafumi.Kawanami, Haruka.Kawanami Iwao, Tomoyuki.Sakai, Yoshimasa.Fujita, Toshihiro.Fukushima, Masatoshi.Saito, Ritsuro.Suzuki, Yuko.Morikawa, Tadashi.Yoshino, Shigeo.Nakamura, Masaru.Kojima, Nozomu.Kurose, Yasuharu.Sato, Yoshiya.Tanaka, Susumu.Sugai, Takayuki.Sumida, Modern Rheumatology, 27:849-854, May 2017
How to diagnose and treat IgG4-related disease, Y.Masaki, S.Fujimoto, H.Kawanami(Iwao), T.Sakai, T.Kawanami, Y.Fujita, H.Kawabata, T.Fukushima, Journal of Kanazawa Medical University, 41:67-72, Dec. 2016
Isolation of vascular smooth muscle antigen-reactive CD4(+)αβTh1 clones that induce pulmonary vasculitis in MRL/Mp-Fas(+/+) mice., Y.Fujita, T.Fujii, H.Shimizu, T.Sato, T.Nakamura, H.Iwao, A.Nakajima, M.Miki, T.Sakai, T.Kawanami, M.Tanaka, Y.Masaki, T.Fukushima, T.Okazaki, H.Umehara, T.Mimori, Cellular immunology, 303:50-54, 2016
DOI:10.1016/j.cellimm.2016.03.004
Proposed diagnostic criteria, disease severity classification and treatment strategy for TAFRO syndrome, 2015 version., Y.Masaki, H.Kawabata, K.Takai, M.Kojima, N.Tsukamoto, Y.Ishigaki , N.Kurose, M.Ide, J.Murakami, K.Nara, H.Yamamoto, Y.Ozawa, H.Takahashi, K.Miura, T.Miyauchi, S.Yoshida, A.Momoi, N.Awano, S.Ikushima, Y.Ohta, N.Furuta, S.Fujimoto, H.Kawanami, T.Sakai, T.Kawanami, Y.Fujita, T.Fukushima, S.Nakamura, T.Kinoshita, S.Aoki, International journal of hematology, 103:686-692, 2016
DOI:10.1007/s12185-016-1979-1
Diagnosis and treatment of IgG4-related disease-Including IgG4-related skin disease-, Y.Masaki, H.Shimizu, T.Nakamura(Satoh), T.Nakamura, A.Nakajima, H.Kawanami(Iwao), T.Kawanami, K.Yamada, Y.Hamaguchi, M.Kawano, Y.Fujita, T.Fukushima, Journal of Environmental Dermatology and Cutaneous Allergology, 9:212-217, Oct. 2015
Decreased expression of innate immunity-related genes in peripheral blood mononuclear cells from patients with IgG4-related disease, A.Nakajima, Y.Masaki, T.Nakamura, T.Kanawami, Y.Ishigaki, T.Takegami, M.Kawano, K.Yamada, N.Tsukamoto, S.Matsui, T.Saeki, K.Okazaki, T.Kamisawa, T.Miyashita, Y.Yakushijin, K.Fujikawa, M.Yamamoto, H.Hamano, T.Origuchi, S.Hirata, H.Tsuboi, T.Sumida, H.Morimoto, T.Sato, H.Iwao, M.Miki, T.Sakai, Y.Fujita, M.Tanaka, T.Fukushima, T.Okazaki, H.Umehara, PLoS One, 10:e0126582-e0126582, May 2015
DOI:10.1371/journal.pone.0126582
CD14+ follicular dendritic cells in lymphoid follicles may play a role in the pathogenesis of IgG4-related disease, T.Satoh-Nakamura, N.Kurose, T.Kawanami, T.Nakamura, H.Iwao-Kawanami, A.Nakajima, M.Miki, T.Sakai, Y.Fujita, M.Tanaka, T.Fukushima, Y.Masaki, Biomedical Research, 36:143-153, Feb. 2015
Prospective clinical study of R-CMD therapy for indolent B cell lymphoma and mantle cell lymphoma from the Hokuriku Hematology Oncology Study Group, T.Sakai, Y.Masaki, N.Otsuki, I.Sakamaki, S.Kishi, T.Miyazono, Y.Urasaki, J.Murakami, T.Satoh, T.Nakamura, H.Iwao, A.Nakajima, T.Kawanami, M.Miki, Y.Fujita, M.Tanaka, T.Fukushima, T.Okazaki, T.Ueda, Medical Oncology, 32:232-238, 2015
Long-term heat exposure prevents hypoxia-induced apoptosis in mouse fibroblast cells, (N.Sugimoto), O.Shido, K.Matsuzaki, M.Katakura, Y.Hitomi, M.Tanaka, T.Sawaki, Y.Fujita, T.Kawanami, Y.Masaki, T.Okazaki, H.Nakamura, S.Koizumi, A.Yachie, H.Umehara, Cell biochemistry and biophysics., 70:301-307, Sep. 2014
Long-term heat exposure prevents hypoxia-induced apoptosis in mouse fibroblast cells, (N.Sugimoto), O.Shido, K.Matsuzaki, M.Katakura, Y.Hitomi, M.Tanaka, T.Sawaki, Y.Fujita, T.Kawanami, Y.Masaki, T.Okazaki, H.Nakamura, S.Koizumi, A.Yachie, H.Umehara, Cell biochemistry and biophysics., 70:301-307, Sep. 2014
IgG4-related disease:Diagnostic methods and therapeutic strategies in Japan, Y.Masaki, H.Shimizu, T.Sato, T.Nakamura, A.Nakajima, H.Iwao, M.Miki, T.Sakai, T.Kawanami, Y.Fujita, M.Tanaka, T.Fukushima, Journal of clinical and experimental hematopathology : JCEH., 54:95-101, 2014
IgG4-related disease and its pathogenesis-cross-talk between innated and acquired immunity, (H.Umehara), A.Nakajima, T.Nakamura, T.Kawanami, M.Tanaka, L.Dong, M.Kawano, International immunology., 26:585-595, 2014
Deficient leptin signaling ameliorates systemic lupus erythematosus lesions in MRL/Mp-Faslpr mice, Y.Fujita, T.Fujii, T.Mimori, T.Sato, T.Nakamura, H.Iwao, A.Nakajima, M.Miki, T.Sakai, T.Kawanami, M.Tanaka, Y.Masaki, T.Fukushima, T.Okazaki, H.Umehara, Journal of immunology (Baltimore, Md. : 1950), 192:979-984, 2014
Deficient leptin signaling ameliorates systemic lupus erythematosus lesions in MRL/Mp-Faslpr mice, Y.Fujita, T.Fujii, T.Mimori, T.Sato, T.Nakamura, H.Iwao, A.Nakajima, M.Miki, T.Sakai, T.Kawanami, M.Tanaka, Y.Masaki, T.Fukushima, T.Okazaki, H.Umehara, Journal of immunology (Baltimore, Md. : 1950), 192:979-984, 2014
Japanese variant of multicentirc cattleman's disease associated with serositis and thrombocytopenia-a report of two cases: Is TAFRO syndrome(Castleman-Kojima Disease) a distinct clinicopathological entity?, Y.Masaki, A.Nakajima, H.Iwao, N.Kurose, T.Sato, T.Nakamura, M.Miki, T.Sakai, T.Kawanami, T.Sawaki, Y.Fujita, M.Tanaka, T.Fukushima, T.Okazaki, H.Umehara, Journal of clinical and experimental hematopathology : JCEH., 53:79-85, Jun. 2013
Upregulation of aquaporin expression in the salivary glands of heat-acclimated rats., (N.Sugimoto), K.Matsuzaki, H.Ishibashi, M.Tanaka, T.Sawaki, Y.Fujita, T.Kawanami, Y.Masaki, T.Okazaki, J.Sekine, S.Koizumi, A.Yachie, H.Umehara, O.Shido, Scientific reports, 3:1763;1-8, 2013
High-dose methotrexate with R-CHOP therapy for the treatment of patients with primary central nervous system lymphoma, Y.Masaki, M.Miki, Y.Sun, T.Nakamura, H.Iwao, A.Nakajima, N.Kurose, T.Sakai, Z.Jin, T.Sawaki, T.Kawanami, Y.Fujita, M.Tanaka, T.Fukushima, Y.Hirose, H.Umehara, International journal of hematology., 93:720-726, 2011
Primary neurolymphomatosis of the cervical nerve root, M.miki, Y.Masaki, T.Nakamura, H.Iwao, A.Nakajima, T.Sakai, T.Sawaki, T.Kawanami, M.Kaito, N.Kurose, Y.Fujita, M.Tanaka, T.Fukushima, Y.Hirose, H.Umehara, 51:564-567, Jul. 2010
Synergistic effects of topoisomerase I inhibitor, SN38, on Fas-mediated apoptosis, Y.Cao, Z.Jin, X.Tong, S.Yue, T.Sakai, T.Kawanami, T.Sawaki, M.Miki, H.Iwao, A.Nakajima, Y.Masaki, Y.Fukushima, Y.Fujita, H.Nakajima, T.Okazaki, H.Umehara, Anticancer research., 30:3911-3918, 2010
DIP2 disco-interacting protein 2 homolog A (Drosophila) is a candidate receptor for follistatin-related protein/follistaitin-like 1 - analysis of their binding with TGF-β superfamily proteins, M.Tanaka, K.Murakami, S.Ozaki, Y.Imura, X.Tong, T.Watanabe, T.Sawaki, T.Kawanami, D.Kawabata, T.Fujii, T.Usui, Y.Masaki, T.Fukushima, Z.Jin, H.Umehara, T.Mimori, The FEBS journal, 277:4278-4289, 2010
Cisplatin augments FAS-mediated apoptosis through lipid rafts, C.Huang, Z.Jin, L.Dong, X.Tong, S.Yue, T.Kawanami, T.Sawaki, T.Sakai, M.Miki, H.Iwao, A.Nakajima, Y.Masaki, Y.Fukushima, M.Tanaka, Y.Fujita, H.Nakajima, T.Okazaki, H.Umehara, Anticancer research., 30:2065-2072, 2010
Intravascular large B cell lymphoma:proposed of the strategy for early diagnosis and treatment of patients with rapid deteriorating condition, Y.Masaki, L.Dong, A.Nakajima, H.Iwao, M.Miki, N.Kurose, E.Kinoshita, T.Nojima, T.Sawaki, T.Kawanami, M.Tanaka, K.Shimoyama, C.Kim, M.Fukutoku, H.Kawabata, T.Fukushima, Y.Hirose, T.Takiguchi, S.Konda, S.Sugai, H.Umehara, International journal of hematology., 89:600-610, Jun. 2009
Proposal for a new clinical entity,IgG4-positive multiorgan lymphoproliferative syndrome:analysis of 64 cases of IgG4-related disorders, Y.Masaki, L.Dong, N.Kurose, K.Kitagawa, Y.Morikawa, M.Yamamoto, H.Takahashi, Y.Shinomura, K.Imai, T.Saeki, A.Azumi, S.Nakada, E.Sugiyama, S.Matsui, T.Origuchi, S.Nishiyama, I.Nishimori, T.Nojima, K.Yamada, M.Kawano, Y.Zen, M.Kaneko, K.Miyazaki, K.Tsubota, K.Eguchi, K.Tomoda, T.Sawaki, T.Kawanami, M.Tanaka, T.Fukushima, S.Sugai, H.Umehara, Annals of the rheumatic diseases., 68:1310-1315, 2009
Impaired TCR signaling through dysfunction of lipidrafts in sphingomyelin synthase 1(SMS1)-knockdown T cells, Z.Jin, C.Huang, L.Dong, S.Goda, T.Kawanami, T.Sawaki, T.Sakai, X.Tong, Y.Masaki, T.Fukushima, M.Tanaka, T.Mimori, H.Tojo, E.Bloom, T.Okazaki, H.Umehara, International immunology., 20:1427-1437, 2008
Analysis of clinical significance of anti-cyclic citrullinated peptide antibody (anti-CCP antibody) in rheumatoid arthritis(RA)., (K.Shimoyama), N.Ogawa, T.Sakai, T.Sawaki, T.Kawanami, H.Karasawa, Y.Masaki, M.Tanaka, T.Fukushima, Y.Hirose, H.Umehara, 30:408-413, Oct. 2007
Cloning and expression of two human recombinant monoclonal Fab fragments specific for EBV viral capsid antigen, L.Dong, Y.Masaki, T.Takegami, T.Kawanami, K.Itoh, Z.Jin, C.Huang, X.Tong, T.Fukushima, M.Tanaka, T.Sawaki, T.Sakai, S.Sugai, T.Okazaki, Y.Hirose, H.Umehara, International immunology., 19:331-336, Mar. 2007
Identification of human salivary stem cells from cultured labial minor salivary cells, T.Kawanami, Y.Matsuzaki, T.Sawaki, T.Sakai, Z.Jin, Y.Masaki, T.Fukushima, M.Tanaka, H.Umehara, 30:455-460, 2007
Clonality analysis of lymphoproliferative disorders in patients with Sjogren's syndrome, L.Dong, Y.Masaki, T.Takegami, Z.Jin, C.Huang, T.Fukushima, T.Sawaki, T.Kawanami, T.Saeki, K.Kitagawa, S.Sugai, T.Okazaki, Y.Hirose, H.Umehara, Clinical and experimental immunology., 150:279-284, 2007
Urinary pseudouridine in patients with lymphoma:Comparison with other clinical parameters, Y.Masaki, K.Itoh, T.Sawaki, H.Karasawa, T.Kawanami, T.Fukushima, H.Kawabata, Y.Wano, Y.Hirose, T.Suzuki, S.Sugai, H.Umehara, Clinica chimica acta; international journal of clinical chemistry., 371:148-151, 2006
Myelodysplastic syndrome complicated with inflammatory intestinal ulcers: significance of trisomy 8, (H.Kawabata), T.Sawaki, T.Kawanami, K.Shimoyama, H.Karasawa, T.Fukushima, Y.Masaki, N.Ogawa, Y.Hirose, K.Ozaki, K.Shimanaka, S.Takase, H.Ueno, H.Umehara, Internal medicine (Tokyo, Japan), 45:1309-1314, 2006
Fractalkine in rheumatoid arthritis and allied conditions, H.Umehara, M.Tanaka, T.Sawaki, Z.X.Jin, C.R.Huang, L.Dong, T.Kawanami, H.Karasawa, Y.Masaki, T.Fukushima, Y.Hirose, T.Okazaki, Modern rheumatology / the Japan Rheumatism Association., 16:124-130, 2006
Sjogren's syndrome, H.Umehara, T.Sawaki, T.Kawanami, Y.Masaki, T.Fukushima, 67:511-516, May 2005
Comprehensive analysis of protein-expression changes specific to immunoglobulin G4-related disease, Takafumi Kawanami, Haruka Kawanami-Iwao, Takanobu Takata, Yasuhito Ishigaki, Naohisa Tomosugi, Tsutomu Takegami, Hiroto Yanagisawa, Shino Fujimoto, Tomoyuki Sakai, Yoshimasa Fujita, Kazunori Yamada, Shuichi Mizuta, Hiroshi Kawabata, Toshihiro Fukushima, Yuko Hirose, Yasufumi Masaki, Clinica Chimica Acta, 523:45-57, 2021
Faggot cells in acute myeloid leukemia with t(7;11)(p15;p15) and NUP98-HOXA9 fusion, Hiroto Yanagisawa, Shuichi Mizuta, Hiroshi Kawabata, Shino Fujimoto, Tomoyuki Sakai, Haruka Iwao-Kawanami, Takafumi Kawanami, Kazunori Yamada, Toshihiro Fukushima, Katsunori Kyoda, Yasufumi Masaki, Annals of Hematology, 100:2121-2123, Aug. 2021
Prognostic impacts of serum levels of C-reactive protein, albumin, and total cholesterol in patients with myelodysplastic syndromes, Hiroto Yanagisawa, Hiroshi Kawabata, Yusuke Ueda, Kotaro Arita, Haruka Iwao-Kawanami, Tomoyuki Sakai, Takafumi Kawanami, Kazunori Yamada, Shuichi Mizuta, Toshihiro Fukushima, Yasufumi Masaki, International Journal of Hematology, 116:81-88, 2022

Note: Performance information for the past 1-2 years may be revised at a later date due to inspections conducted by the committee from July to September every year.