KAJINAMI Kouji

■FacultyDepartment of Cardiology
■PositionProfessor

Researcher Profile & Settings

Research

    Overview of research:
    Atherosclerosis, lipid metabolism

Special Field

  • Endocrinology and Metabolic Science
  • Mechanical Engineering
  • Cardioangiology

Degree

  • Ph.D in Medicine

Academic & Professional Experience

  • 1999Kanazawa University  Assistant Professor
  • 1999- 2001Kanazawa Medical University  Assistant Professor
  • 2001Kanazawa Medical University Associate Professor
  • 2004Kanazawa Medical University Professor

Research Activities

Published Papers

  • Issues and Procedures for Improving Safety Management of Inpatients with Cardiovascular Diseases Taking Multiple Medications, Ichiko Nakada, Minoru Wakasa, Katsuhiko Takano, Chie Ohta, Reiko Koikeda, Masanori Aikawa, Yoshimitsu Takahashi, Yasuo Iida, Kouji Kajinami, Journal of Geriatric Pharmacy, 4:15-20, 2021
  • Statin Intolerance Clinical Guide 2018, Kouji Kajinami, Kazuhisa Tsukamoto, Shinji Koba, Ikuo Inoue, Masashi Yamakawa, Shigeaki Suzuki, Tadanori Hamano, Hidetsugu Saito, Yoshiro Saito, Satohiro Masuda, Takeo Nakayama, Tomonori Okamura, Shizuya Yamashita, Tatehiro Kagawa, Junji Kaneyama, Akira Kuriyama, Rumi Tanaka, Aya Hirata, Journal of Atherosclerosis and Thrombosis, 27:375-396, Apr. 2020
  • Guidelines on the Clinical Evaluation of Medicinal Products for Treatment of Dyslipidemia, Shizuya Yamashita, Daisaku Masuda, Masahiro Akishita, Hidenori Arai, Yujiro Asada, Kazushige Dobashi, Kensuke Egashira, Mariko Harada-Shiba, Kenichi Hirata, Shun Ishibashi, Kouji Kajinami, Makoto Kinoshita, Koichi Kozaki, Masafumi Kuzuya, Masatsune Ogura, Tomonori Okamura, Kayoko Sato, Hitoshi Shimano, Kazuhisa Tsukamoto, Masayuki Yokode, Koutaro Yokote, Masayuki Yoshida, Journal of Atherosclerosis and Thrombosis, 27:1246-1254, Nov. 2020
  • Evolocumab vs. Ezetimibe in Statin-Intolerant Hyperlipidemic Japanese Patients: Phase 3 GAUSS-4 Trial, (Shinji Koba), Ikuo Inoue, Marcoli Cyrille, Chen Lu, Hyoe Inomata, Junichiro Shimauchi, Kouji Kajinami, Journal of Atherosclerosis and Thrombosis, 27:471-484, May 2020
  • Possible effect of direct oral anti-coagulant for preventing long stenting lesion from in-stent restenosis in femoropopliteal segment: Case report with angioscopy findings, Tsuchiya Taketsugu, Akita Satori, Oda Minako, Takamura Takaaki, Kitagawa Katsuhide, Kajinami Koji, Kitayama Michihiko, SAGE open medical case reports, 8:2050313X20945535, Jul. 2020
  • Hokuriku-plus familial hypercholesterolaemia registry study: rationale and study design, Tada Hayato, Okada Hirofumi, Yoshida Shohei, Shimojima Masaya, Nomura Akihiro, Tsuda Toyonobu, Mori Mika, Takashima Shin-ichiro, Kato Takeshi, Usui Soichiro, Sakata Kenji, Hayashi Kenshi, Fujino Noboru, Inazu Akihiro, Takahara Shizuko, Imai Yasuhito, Matsubara Takao, Nohara Atsushi, Miwa Kenji, Namura Masanobu, Terai Hidenobu, Yoshida Taiji, Araki Tsutomu, Minamoto Masahiro, Aburao Toru, Ito Yuji, Nakanishi Chiaki, Kawasaki Suguru, Todo Yasuhiro, Koizumi Junji, Kita Yoshihito, Matsumoto Hiroshi, Shintaku Hiroaki, Hodatsu Akihiko, Ino Hidekazu, Higashikata Toshinori, Takata Mutsuko, Misawa Katsushi, Yamaguchi Masato, Noji Yoshihiro, Osato Kazuo, Mabuchi Tomohito, Ichise Taro, Kaku Bunji, Katsuda Shoji, Fujimoto Manabu, Uchiyama Katsuharu, Fujioka Kensuke, Nakahashi Takuya, Nozue Tsuyoshi, Michishita Ichiro, Usuda Kazuo, Otowa Kanichi, Okeie Kazuyasu, Hirota Satoshi, Aburadani Isao, Kurokawa Keisuke, Takatori Osamu, Hondo Shunichiro, Oda Hiroyuki, Takata Shigeo, Murai Hisayoshi, Kinoshita Masaki, Nagai Hideo, Sekiguchi Yoshiteru, Sakagami Satoru, Omi Wataru, Fujita Chikara, Katsuki Tatsuo, Ootsuji Hiroshi, Igarashi Atsushi, Nakano Manabu, Okura Seiichiro, Maeno Koji, Mitamura Yasuhito, Sugimoto Naoki, Yamamoto Masakazu, Akao Hironobu, Kajinami Kouji, Takamura Masayuki, Kawashiri Masa-aki, BMJ open, 10:e038623, Sep. 2020
  • Monitoring the roles of prothrombin activation fragment 1 and 2 (F1+2) in patients with atrial fibrillation receiving rivaroxaban and apixaban, Ueno Ei-ichi, Fujibayashi Kosuke, Sawaguchi Jun, Yasuda Yushi, Takano Shintaro, Fujioka Nakaba, Kawai Yasuyuki, Fujita Harumi, Tanaka Yoshi, Kajinami Kouji, Journal of Thrombosis and Thrombolysis, 50:371-379, Aug. 2020
  • Preliminary quantitative evaluation of radiation-induced DNA damage in peripheral blood lymphocytes after cardiac dual-isotope imaging, Koichi Okuda, Naoto Watanabe, Mitsumasa Hashimoto, Mariko Doai, Yasuyuki Kawai, Tomoko Takahashi, Tomohiro Arikawa, Kazumasa Ooiso, Yumi Sunatani, Kuniyoshi Iwabuchi, Koji Kajinami, Munetaka Matoba, Applied Radiation and Isotopes, 154:108890, Dec. 2019
  • Microdosing clinical study to clarify pharmacokinetic and pharmacogenetic characteristics of atorvastatin in Japanese hypercholesterolemic patients, (Nora Lee), Kazuya Maeda, Shinya Fukizawa, Ichiro Ieiri, Atsuko Tomaru, Hironobu Akao, Kenji Takeda, Mizuho Iwadare, Osamu Niwa, Tougen Masauji, Naoe Yamane, Kouji Kajinami, Hiroyuki Kusuhara, Yuichi Sugiyama, Drug Metabolism and Pharmacokinetics, 34:387-395, Dec. 2019
  • Real-World Data to Identify Hypercholesterolemia Patients on Suboptimal Statin Therapy, Kouji Kajinami, Asuka Ozaki, Yuki Tajima, Shizuya Yamashita, Hiddenori Arai, Tamio Teramoto, Journal of Atherosclerosis and Thrombosis, 26:408-431, May 2019
  • Possibly Late-Onset Arrhythmogenic Right Ventricular Cardiomyopathy: Unique Triglyceride Deposition by Analysis of Lipid Contents, Yamamoto K, Guo X, Mizutani KI, Kurose N, Kumagai M, Shioya A, Nakada S, Terauchi T, Ikeda Y, Aoki H, Kajinami K, Yamada S, Clinical Medicine Insights. Case Reports, 12:1179547619828715, Feb. 2019
  • Healing of femoral artery dissection after drug-coated balloon angioplasty: A case report with intravascular ultrasonography and angioscopy images, Taketsugu Tsuchiya, Minako Oda, Takaaki Takamura, Katsuhide Kitagawa, Koji Kajinami, Michihiko Kitayama, SAGE Open Medical Case Reports, 7:2050313X19834159, Feb. 2019
  • Treatment Patterns, Statin Intolerance, and Subsequent Cardiovascular Events Among Japanese Patients With High Cardiovascular Risk Initiating Statin Therapy., Nagar Saurabh P;Rane Pratik P;Fox Kathleen M;Meyers Juliana;Davis Keith;Beaubrun Anne;Inomata Hyoe;Qian Yi;Kajinami Kouji, CIRCULATION JOURNAL, 82:1008-1016, Apr. 2018
  • Towards Effective Cost-Effectiveness Analysis in Atherosclerotic Cardiovascular Disease Prevention, Kouji Kajinami, Circulation Journal, 82:954-955, Mar. 2018
  • Efficacy and Safety of an Orally Administered Selective Prostacyclin Receptor Agonist, Selexipag, in Japanese Patients With Pulmonary Arterial Hypertension, Tanabe, Nobuhiro;Ikeda, Satoshi;Tahara, Nobuhiro;Fukuda, Keiichi;Hatano, Masaru;Ito, Hiroshi;Nakayama, Tomotaka;Anzai, Toshihisa;Hashimoto, Akiyoshi;Inoue, Teruo;Kajinami, Kouji;Kihara, Yasuki;Kinoshita, Hideyuki;Kuwahara, Koichiro;Murohara, Toyoaki;Okazaki, Osamu;Sakai, Satoshi;Satoh, Toru;Takeda, Yutaka;Takeishi, Yasuchika;Taniguchi, Mitsugu;Watanabe, Hiroshi;Yamamoto, Takeshi;Yamauchi-Takihara, Keiko;Yoshioka, Koichiro;Sasayama, Shigetake, CIRCULATION JOURNAL, 81:1360-1367, Sep. 2017
  • Circulating malondialdehyde-modified low-density lipoprotein (MDA-LDL) as a novel predictor of clinical outcome after endovascular therapy in patients with peripheral artery disease (PAD), Takamura, Taka-aki;Tsuchiya, Taketsugu;Oda, Minako;Watanabe, Makoto;Saito, Ryuhei;Sato-Ishida, Ryoko;Akao, Hironobu;Kawai, Yasuyuki;Kitayama, Michihiko;Kajinami, Kouji, ATHEROSCLEROSIS, 263:192-197, Aug. 2017
  • Diurnal glycemic fluctuation is associated with severity of coronary artery disease in prediabetic patients: Possible role of nitrotyrosine and glyceraldehyde-derived advanced glycation end products., M.Watanabe, Y.Kawai, M.Kitayama, H.Akao, A.Motoyama, M.Wakasa , R.Saito, H.Aoki, K.Fujibayashi, T.Tsuchiya, H.Nakanishi, K.Saito, M.Takeuchi, K.Kajinami, Journal of Cardiology, 69:625-631, Apr. 2017
  • Prediction of all-cause death using (11)C-hydroxyephedrine positron emission tomography in Japanese patients with left ventricular dysfunction., W.Fujita, I.Matsunari, H.Aoki, S G.Nekolla, K.Kajinami, Annals of nuclear medicine, 30:461-467, Aug. 2016
  • Chronic total occlusions of the right coronary and left anterior descending coronary arteries in a young adult patient with antiphospholipid syndrome, Y.Kawai, M.Kitayama, A.Motoyama, M.Wakasa, R.Saito, H.Aoki, K.Fujibayashi, M.Watanabe, T.Takamura, H.Akao, T.Tsuchiya, K.Kajinami, Journal of Cardiology Cases, 14:46-48, Aug. 2016
  • 18F-FDG PET/CT for Detecting Sarcoma of the Aorta in a Patient with Takayasu Arteritis, T.Takahashi, N.Watanabe, M.Wakasa, K.Kajinami, H.Tonami, Nuclear medicine and molecular imaging, 50:171-172, Jun. 2016
  • Circulating Glutamate and Taurine Levels Are Associated with the Generation of Reactive Oxygen Species in Paroxysmal Atrial Fibrillation, S.Takano, K.Fujibayashi, N.Fujioka, E.Ueno, M.Wakasa, Y.Kawai, K.Kajinami, Disease Markers, 2016:1-7, 2016
  • Lipoprotein(a): Revisiting a Next Therapeutic Target., K.Kajinami, Circulation journal, 80:329-331, 2016
  • A case of coronary rupture and pseudoaneurysm formation after fracture of implanted paclitaxel-eluting stents., Y.Kawai, M.Kitayama, H.Akao, A.Motoyama, T.Tsuchiya, K.Kajinami, Cardiovascular intervention and therapeutics, 31:231-237, 2016
  • A possible role for HLA-DRB1*04:06 in statin-related myopathy in Japanese patients, (K.Sai), K.Kajinami, H.Akao, M.Iwadare, R.Sato-Ishida, Y.Kawai, K.Takeda, T.Tanimoto, T.Yamano, T.Akasaka, T.Ishida, K.Hirata, K.Saku, S.Yagi, T.Soeki, M.Sata, M.Ueno, S.Miyazaki, A.Shiraki, J.Oyama, K.Node, K.Sugamura, H.Ogawa, K.Kurose, K.Maekawa, Y.Matsuzawa, T.Imatoh, R.Hasegawa, Y.Saito, Drug metabolism and pharmacokinetics, 31:467-470, 2016
  • Clinical characteristics of patients with Rutherford category IV, compared with V and VI, T.Tsuchiya, O.Iida, T.Shiraki, Y.Soga, K.Hirano, K.Suzuki, T.Yamaoka, Y.Miyashita, M.Kitayama, K.Kajinami, SAGE open medicine, 3:2050312115597087-2050312115597087, Jul. 2015
  • Nutri-pharmacogenomics of warfarin anticoagulation therapy : VKORC1 genotype-dependent influence of dietary vitamin K intake, R.Saito, K.Takeda, K.Yamamoto, A.Nakagawa, H.Aoki, K.Fujibayashi, M.Wakasa, A.Motoyama, M.Iwadare, R.Ishida, N.Fujioka, T.Tsuchiya, H.Akao, Y.Kawai, M.Kitayama, K.Kajinami, Journal of thrombosis and thrombolysis., 38:105-114, Jul. 2014
  • ABCA1 gene variation and heart disease risk reduction in the elderly during pravastatin treatment, H.Akao, E.Polisecki, EJ.Schaefer, S.Trompet, M.Robertson, I.Ford, JW.Jukema, AJ.de Craen, C.Packard, BM.Buckley, K.Kajinami, Atherosclerosis., 235:176-181, May 2014
  • Increased levels of the oxidative stress marker, nitrotyrosine in patients with provocation test-induced coronary vasospasm, K.Tanabe, Y.Kawai, M.Kitayama, H.Akao, R.Ishida, A.Motoyama, M.Wakasa, R.Saito, H.Aoki, K.Fujibayashi, M.Watanabe, T.Tsuchiya, H.Kimura, K.Yoshida, K.Kajinami, Journal of cardiology, 64:86-90, Jan. 2014
  • Myocardial sympathetic innervation, function, and oxidative metabolism in non-infarcted myocardium in patients with prior myocardial infarction, H.Aoki, I.Matsunari, Y.Nomura, W.Fujita, R.Komatsu, Y.Miyazaki, SG.Nekolla, K.Kajinami, Annals of nuclear medicine., 27:523-531, 2013
  • Chk1-mediated phosphorylation of receptor-associated late transducer at serine 250 increases its stability by stimulating its interaction with 14-3-3., K.Takeda, T.Takata, Y.Kawai, Y.Ishigaki, K.Kajinami, Genes to cells : devoted to molecular & cellular mechanisms, 18:369-386, 2013
  • Place of pitavastatin in the statin armamentarium : promising evidence for a role in diabetes mellitus, Y.Kawai, R.Ishida, A.Motoyama, K.Kajinami, Drug design, development and therapy [electronic resource], 5:283-297, May 2011
  • Levels of serum deoxyribonuclease Ⅰactivity on admission in patients with acute myocardial infarction can be useful in predicting left ventricular enlargement due to remodeling, (J.Kuribara), H.Tada, Y.Kawai, R.Kawaguchi, H.Hoshizaki, K.Arakawa, M.Kitayama, K.Kajinami, M.Kurabayashi, S.Oshima, K.Taniguchi, Y.Kominato, T.Yasuda, Journal of cardiology, 53:196-203, Oct. 2009
  • Marked PT-INR prolongation associated with appetite loss due to urinary tract infection in a late elderly case with chronic atrial fibrillation, R.Saito, H.Akao, K.Kaseno, Y.Nomura, M.Kitayama, H.Tsugawa, K.Kajinami, 46:541-544, Jun. 2009
  • Synergy of aldosterone and high salt induces vascular smooth muscle hypertrophy through up-regulation of NOX1, (Chun Yuan), Y.Kawai, S.Inaba, K.Arakawa, M.Katsuyama, K.Kajinami, T.Yasuda, C.Yabe-Nishimura, T.Konoshita, I.Miyamori, The Journal of steroid biochemistry and molecular biology, 111:29-36, Aug. 2008
  • Synergy of aldosterone and high salt induces vascular smooth muscle hypertrophy through up-regulation of NOX1, (CY Fan), Y.Kawai, M Katsuyama, C Yabe-Nishimura, K Arakawa, T Yasuda, K.Kajinami, S Inaba, T Konoshita, I Miyamori, J Steroid Biochem Mol Biol, 111:29-36, Aug. 2008
  • Regulation of pssitive feedback loop of HB-EGF signal by gene 33/ralt in H9c2 cells, K.Takeda, S.Akazawa, Y.Kawai, K.Kajinami, 33:76-85, Aug. 2008
  • LDL apheresis int the prevention of coronary atherosclerosis, A.Motoyama, H.Akao, K.Kajinami, 27:42-46, Jan. 2008
  • Serum deoxyribonuclease I activity can be used as a novel marker of transient myocardial ischemia:results in vasospastic angina pectoris induced by provocation test, (N.Morikawa), Y.Kawai, K.Arakawa, T.Kumamoto, I.Miyamori, H.Akao, M.Kitayama, K.Kajinami, Jong-Dag Lee, H.Takeshita, Y.Kominato, T.Yasuda, European heart journal, 28:2992-2997, Dec. 2007
  • Role of a novel conduction pattern around the coronary sinus in cavotricuspid isthmus dependent right atrial flutter, Y. Yamaguchi, H.Tsugawa, N.Fujioka, K.Kaseno, M.Kitayama, K.Kajinami, Journal of cardiology, 50:1-10, Jan. 2007
  • Pharmacogenomics of statin responsiveness, K.Kajinami, H.Akao, Eliana Polisecki, Ernst J Schaefer, Am J Cardiol, 96:65K-70K, Nov. 2005
  • Pitavastatin: efficacy and safety profile of a novel synthetic HMG-CoA reductase inhibitor, KAJINAMI Kouji, Cardiovasc Drug Rev, 2003
  • Effect of pretreatment vitamin D levels on in vivo effects of atorvastatin on bone metabolism in patients with heterozygous familial hypercholesterolemia., KAJINAMI Kouji, Am J Cardiol, 2003
  • Long-Term treatment with pitavastatin (NK-104), a new HMG-CoA reductase inhibitor, of patients with heterozygous familial hypercholesterolemia , KAJINAMI Kouji, Atherosclerosis, 2002
  • Effects of serum B vitamins on elevated plasma homocysteine levels associated with the mutation of methylenetetrahydrofolate reductase gene in Japanese, KAJINAMI Kouji, Atherosclerosis, 2002
  • Cholesterol Absorption Inhibitors in Development as Potential Therapeutics , KAJINAMI Kouji, Expert Opinion on Investigational Drugs, 2002
  • Hyperhomocysteinemia, diabetes mellitus, and carotid atherosclerosis independently increase atherosclerotic vascular disease outcome in Japanese patients with end-stage renal disease, KAJINAMI Kouji, Clin Nephrol, 2001
  • Circulating matrix metalloproteinases and their inhibitors in premature coronary atherosclerosis, KAJINAMI Kouji, Clin Chem Lab Med, 2001
  • NK-104 : a novel synthetic HMG-CoA reductase inhibitor.(共著), KAJINAMI Kouji, Expert Opinion on Investigational Drugs, 2000
  • Effects of common methylenetetrahydrofolate reductase gene mutation on coronary artery disease in familial hypercholesterolemia(共著), KAJINAMI Kouji, Am J Cardiol, 2000
  • Effects of NK-104, a new hydroxy-methylglutaryl-coenzyme reductase inhibitor, on low density lipoprotein cholesterol in heterozygous familial hypercholesterolemia. (共著), KAJINAMI Kouji, Am J Cardiol, 2000
  • Additive effects of another kind of HMG-CoA reductase inhibitor with different pharmakokinetics in the treatment of heterozygous familial hypercholesterolemia, KAJINAMI Kouji, Atherosclerosis, 2000
  • Therapeutic effects of LDL apheresis in the prevention of atherosclerosis(共著), KAJINAMI Kouji, Curr Opin Lipidol, 1999
  • Plasma homocysteine level and development of coronary astery disease (共著), KAJINAMI Kouji, Coronary Artery Disease, 1999
  • Coronary ectasia in familial hypercholesterolemia : histopathologic study regarding matrix metalloproteinases(共著), KAJINAMI Kouji, Modern Pathol, 1999
  • Low-density lipoprotein receptor genotype-dependent response to cholesterol lowering by combined pravastatin and cholestyramine in familial hypercholesterolemia, KAJINAMI Kouji, Am. J. Cardiol., 1998
  • Non-invasive detection of quadricuspid aortic valve., KAJINAMI Kouji, Heart, 1997
  • Coronary calcification and coronary atherosclerosis : site by site comparative morphologic study of electron beam computed tomography and coronary angiography., KAJINAMI Kouji, J. Am. Coll. Cardiol., 1997
  • Long-term probucol treatment results in regression of xanthomas, but progression of coronary atherosclerosis in a heterozygous patient with familial hypercholesterolemia, KAJINAMI Kouji, Atherosclerosis, 1996
  • Comparative merits of electron beam computed tomography when coronary atherosclerosis is suspected., KAJINAMI Kouji, Cardiology Review, 1996
  • Noninvasive prediction of coronary atherosclerosis by quantification of coronary artery calcification using electron beam computed tornography ; comparison with electrocardiographic and thallium exercise stress test results., KAJINAMI Kouji, J. Am Coll Cardiol, 1995
  • Omeprazole and diminished antianginal drug delivery., KAJINAMI Kouji, Ann. Intern. Med., 1994
  • Quantification of coronary artery calcification using ultrafast computed tomography : reproducibility of measurements., KAJINAMI Kouji, Coronary Artery Disease, 1993
  • Propranolol for probucol-induced QT prolongation with polymorphic ventricular tachycardia, KAJINAMI Kouji, Lancet, 1993
  • Internal mammary-to-coronary artery communication in a patient with occluded right coronary artery., KAJINAMI Kouji, Am. Heart J., 1993
  • Serum apolipoproteins in heferozygous familial hypercholesterolemia, KAJINAMI Kouji, Clin. Chim. Acta., 1992
  • Novel gene mutations at the low density lipoprotein receptor locus. FH-Kanazawa and FH-Okayama, KAJINAMI Kouji, J. Intern. Med., 1990
  • Asymptomatic congenital subclavian steal in a young male patient with right aortic arch., KAJINAMI Kouji, Chest, 1990
  • LDL receptor gene mutation in Japanese patients with familial hypercholesterolemia., KAJINAMI Kouji, 1989
  • New variant of low density lipoprotein receptor gene. FH-Tonami, KAJINAMI Kouji, Arteriosclerosis, 1988
  • A case of heterozygous familial hypercholesterolemia associated with Schnyder's corneal dystrophy., KAJINAMI Kouji, Jpn J Intern Med, 1988
  • A Novel Approach: Investigating the Intracellular Clearance Mechanism of Glyceraldehyde-Derived Advanced Glycation End-Products Using the Artificial Checkpoint Kinase 1 d270KD Mutant as a Substrate Model, Kenji Takeda, Akiko Sakai-Sakasai, Kouji Kajinami, Masayoshi Takeuchi, Cells, 12:2838-2838, Dec. 2023