FacultyNatural Sciences
PositionAssociate Professor

Researcher Profile & Settings


    Overview of research:
    The main study of mine is the PKU-beta/TLK1 that is related to the cell cycle progression, espacially mitosis. It is being done by the means and the views of cell biology, biochemistry and molecular biology. In addition, the mechanism of phenomena that PKU-beta/TLK1 contributes to DNA repair is also studyed.


  • Kanazawa University Graduate School Division of National Science and Technology
  • Doshisha University Faculty of Engineering


  • Doctor of Pharmacy

Academic & Professional Experience

  • Apr. 1999Emory University
  • Jul. 2001New York University

Research Activities

Published Papers

  • Calibrated scintigraphic imaging procedures improve quantitative assessment of the cardiac sympathetic nerve activity, Koichi Okuda, Kenichi Nakajima, Chiemi Kitamura, Yumiko Kirihara, Mitsumasa Hashimoto, Seigo Kinuya, Scientific reports10:21834Dec. 2020
  • Preliminary quantitative evaluation of radiation-induced DNA damage in peripheral blood lymphocytes after cardiac dual-isotope imaging, Koichi Okuda, Naoto Watanabe, Mitsumasa Hashimoto, Mariko Doai, Yasuyuki Kawai, Tomoko Takahashi, Tomohiro Arikawa, Kazumasa Ooiso, Yumi Sunatani, Kuniyoshi Iwabuchi, Koji Kajinami, Munetaka Matoba, Applied Radiation and Isotopes154:108890Dec. 2019
  • Caspase-mediated cleavage of X-ray repair cross-complementing group 4 promotes apoptosis by enhancing nuclear translocation of caspase-activated DNase., Yumi.Sunatani, Radhika Pankaj Kamdar, Mukesh Kumar Sharma, Tadashi.Matsui, Ryo.Sakasai, Mitsumasa.Hashimoto, Yasuhito.Ishigaki, Yoshihisa.Matsumoto, Kuniyoshi.Iwabuchi, Experimental cell research362:450Jan. 2018
  • Comparison of diagnostic performance of four software packages for phase dyssynchrony analysis in gated myocardial perfusion SPECT, Okuda, Koichi;Nakajima, Kenichi;Matsuo, Shinro;Kashiwaya, Soichiro;Yoneyama, Hiroto;Shibutani, Takayuki;Onoguchi, Masahisa;Hashimoto, Mitsumasa;Kinuya, Seigo, EJNMMI RESEARCH7:---Mar. 2017
  • Cardiac and Respiratory Motion-induced Artifact in Myocardial Perfusion SPECT, Okuda Koichi;Nakajima Kenichi;Kikuchi Akihiro;Onoguchi Masahisa;Hashimoto Mitsumasa, Annals of Nuclear Cardiology3:88-932017
  • Development and validation of a direct-comparison method for cardiac I-123-metaiodobenzylguanidine washout rates derived from late 3-hour and 4-hour imaging, K.Okuda, K.Nakajima, S.Sugino, Y.Kirihara, S.Matsuo, J.Taki, M.Hashimoto, S.Kinuya, European Journal of Nuclear Medicine and Molecular Imaging43:319-325Feb. 2016
  • Optimization of iterative reconstruction parameters with attenuation correction, scatter correction and resolution recovery in myocardial perfusion SPECT/CT., K.Okuda, K.Nakajima, M.Yamada, H.Wakabayashi, H.Ichikawa, H.Arai, S.Matsuo, J.Taki, M.Hashimoto, S.Kinuya, Annals of nuclear medicine.28:60-68Jan. 2014
  • Depletion of RNA-binding protein RBM8A (Y14) causes cell cycle deficiency and apoptosis in human cells., Y.Ishigaki, Y.Nakamura, T.Tatsuno, M.Hashimoto, T.Shimasaki, K.Iwabuchi, N.Tomosugi, Experimental biology and medicine (Maywood, N.J.)238:889-8972013
  • DNA ligase IV and artemis act cooperatively to suppress homologous recombination in human cells: Implications for DNA double-strand break repair., (A.Kurosawa), S.Saito, S.So, M.Hashimoto, K.Iwabuchi, H.Watabe, N.Adachi, PloS one8:e72253;1-112013
  • RAD18 promotes DNA double-strand break repair during G1 phase through chromatin retention of 53BP1, (K.Watanabe), K.Iwabuchi, J.Sun, Y.Tsuji, T.Tani, K.Tokunaga, T.Date, M.Hashimoto, M.Yamaizumi, S.Tateishi, Nucleic acids research37:2176-2193Jan. 2009
  • PKU-β/TLK1 regulates myosin Ⅱ activities, and is required for accurate equaled chromosome segregation, M.Hashimoto, T.Matsui, K.Iwabuchi, T.Date, Mutation research657:63-67Sep. 2008
  • Characterization of a cancer cell line that expresses a splicing variant form of 53BP1:Separation of checkpoint and repair functions in 53BP1, K.Iwabuchi, T.Matsui, M.Hashimoto, Y.Matsumoto, T.Kurihara, T.Date, Biochemical and biophysical research communications376:509-513Sep. 2008
  • Cell sorting analysis of cell cycle-dependent X-ray sensitivity in end joining-deficient human cells, K.Iwabuchi, M.Hashimoto, T.Matsui, A.Kurosawa, N.Adachi, T.Date, Biochemical and biophysical research communications372:662-667May 2008
  • 53BP1 contributes to survival of cells irradiated with X-ray during G1 without Ku70 or Artemis., K.Iwabuchi, M.Hashimoto, T.Matsui, T.Kurihara, H.Shimizu, N.Adachi, M.Ishiai, K-I.Yamamoto, H.Tauchi, M.Takata, H.Koyama, T.Date, Genes to cells : devoted to molecular & cellular mechanisms11: 935-948Aug. 2006
  • Induction of centrosome amplification in p53 siRNA-treated human fibroblast cells by radiation exposure, K.Kawamura, N.Morita, C.Domiki, K.Fujikawa-Yamamoto, M.Hashimoto, K.Iwabuchi, K.Suzuki, Cancer science.97:252-2582006
  • HU protein of Escherichia coli has a role in the repair of closely opposed lesions in DNA, HASHIMOTO Mitsumasa, J. Biol. chem.2003
  • DNA-PK: the major target for Wortmanniu mediated radiosensitization by the inhibitor of DSB repair uia NHEJ pathway, HASHIMOTO Mitsumasa, J. Radiat. Res (Tokyo)2003
  • The 2-deoxyribonolactone lesion produced in DNA by neocarzinostatin and other damaging agents forms cross-links with the base-excision repair enzyme endonuclease III., J Am Chem Soc.123(13):3161-3162Apr. 2001
  • A Possible role for Ku in mediating sequential repair of closely opposed lesions, HASHIMOTO Mitsumasa, J. Biol. chem2001

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