ICHISEKI Toru

Researcher Profile & Settings

Research

Overview of research:
We are researching some factors such an intravascular obstructive lesion or oxidative stress that would be cause for steroid induced osteonecrosis of femoral head to prevent the occurrence of the disease.

Special Field

• Orthopaedic surgery

Education

• Kanazawa Medical University Graduate School Division of Medicine
• Juntendo University Faculty of Medicine

Degree

• Ph.D in Medicine

Association Memberships

• 1997Japanese Orthopaedic Association
• 2001Japanese Hip Society
• 2001Japanese Society for Replacement Arthroplasty
• 2014Japan Shoulder Society

Academic & Professional Experience

• Apr. 2009Kanazawa Medical University Graduate Associate Professor

Research Activities

Published Papers

• Synovial fluid derived from human knee osteoarthritis increases the viability of human adipose-derived stem cells through upregulation of FOSL1, Hironori Kitajima, Takuya Sakamoto, Tetsuhiro Horie, Ayane Kuwano, Atsushi Fuku, Yasuhiko Taki, Yuka Nakamura, Ikuhiro Tanida, Hiroshi Sunami, Hiroaki Hirata, Yoshiyuki Tachi, Naoki Yamamoto, Yasuo Iida, Yasuhito Ishigaki, Sohsuke Yamada, Shigetaka Shimodaira, Yusuke Shimizu, Toru Ichiseki, Ayumi Kaneuji, Satoshi Osawa and Norio Kawahara, Cells, 12:330, Jan. 2023
  DOI:10.3390/cells12020330
• Efficacy of rectal systemic administration of mesenchymal stem cells to injury sites via the CXCL12/CXCR4 axis to promote regeneration in a rabbit skeletal muscle injury model, Toru Ichiseki, Miyako Shimasaki, Shusuke Ueda, Hiroaki Hirata, Daisuke Souma, Norio Kawahara and Yoshimichi Ueda, Cells, 12:1729, Jun. 2023
  DOI:10.3390/cells12131729
• Septic arthritis of cervical spine facet joints: A case report and review of imaging, Hironori Kitajima, Eiju Hatano, Masahito Kawaguchi, Takuya Sakamoto, Toru Ichiseki, Ayumi Kaneuji, Norio Kawahara, The American journal of case reports, 24:e941578, Oct. 2023
  DOI:10.12659/AJCR.941578
• A case of axillaryWeb syndrome caused by venous blood sampling, Hironori Kitajima, Toru Ichiseki, Ayumi Kaneuji and Norio Kawahara, Healthcare (Basel), 11:2390, Aug. 2023
  DOI:10.3390/healthcare11172390
• Collarless polished tapered stems of identical shape povide differing outcomes for stainless steel and cobalt chrome: A biomechanical study, Ayumi Kaneuji, Mingliang Chen, Eiji Takahashi, Noriyuki Takano, Makoto Fukui, Daisuke Soma, Yoshiyuki Tachi, Yugo Orita, Toru Ichiseki and Norio Kawahara, Journal of Functional Biomaterials, 14:262, May 2023
  DOI:10.3390/jfb14050262
• Angular changes in pelvic tilt and cup orientation at a minimum of eighteen years after primary total hip arthroplasty with an uncemented cup, Mingliang Chen, Ayumi Kaneuji, Eiji Takahashi, Makoto Fukui, Toru Ichiseki, Norio Kawahara, International Orthopaedics, 47:75-81, Jan. 2023
  DOI:10.1007/s00264-022-05610-y
• Does the dual mobility cup reduce dislocation after primary total hip arthroplasty in elderly patients at high risk of dislocation?, Mingliang Chen, Eiji Takahashi, Ayumi Kaneuji, Yoshiyuki Tachi, Makoto Fukui, Yugo Orita, Toru Ichiseki, You Zhou, Norio Kawahara, Orthopaedic Surgery, 15:496-501, Feb. 2023
  DOI:10.1111/os.13613
• A morphological study of adipose-derived stem cell sheets created with temperature-responsive culture dishes using scanning electron microscopy, Yasuhiko Taki, Atsushi Fuku, Yuka Nakamura, Terutsugu Koya, Hironori Kitajima, Ikuhiro Tanida, Takashi Takaki, Kaori Nozaki, Hiroshi Sunami, Hiroaki Hirata, Yoshiyuki Tachi, Takeo Shimasaki, Togen Masauji, Naoki Yamamoto, Yasuhito Ishigaki, Shigetaka Shimodaira, Yusuke Shimizu, Toru Ichiseki, Ayumi Kaneuji, Satoshi Osawa, Norio Kawahara, Medical Molecular Morphology, 55:187-198, Sep. 2022
  DOI:10.1007/s00795-022-00319-8
• Inhibitory effect of taurine on rotator cuff degeneration via mitochondrial protection, Shusuke Ueda, Toru Ichiseki, Miyako Shimasaki, Hiroaki Hirata, Norio Kawahara, Yoshimichi Ueda, American Journal of Translational Research, 14:6286-6294, Sep. 2022
• Evaluation of the usefulness of human adipose-derived stem cell spheroids formed using SphereRing® and the lethal damage sensitivity to synovial fluid in vitro, Atsushi Fuku, Yasuhiko Taki, Yuka Nakamura, Hironori Kitajima, Takashi Takaki, Terutsugu Koya, Ikuhiro Tanida, Kaori Nozaki, Hiroshi Sunami, Hiroaki Hirata, Yoshiyuki Tachi, Togen Masauji, Naoki Yamamoto, Yasuhito Ishigaki, Shigetaka Shimodaira, Yusuke Shimizu, Toru Ichiseki, Ayumi Kaneuji, Satoshi Osawa, Norio Kawahara, Cells, 11:337, Jan. 2022
  DOI:10.3390/cells11030337
• Resistance of bone marrow mesenchymal stem cells in a stressed environment - Comparison with osteocyte cells, Miyako Shimasaki, Shusuke Ueda, Toru Ichiseki, Hiroaki Hirata, Norio Kawahara, Yoshimichi Ueda, International Journal of Medical Sciences, 18:1375-1381, Jan. 2021
  DOI:10.7150/ijms.52104
• Long-term outcomes for cementless anatomic femoral components, compared by area of porous coating, in patients younger than 50 years treated for hip dysplasia, Ayumi Kaneuji, Eiji Takahashi, Makoto Fukui, Toru Ichiseki, Kiyokazu Fukui, Norio Kawahara, The Journal of Arthroplasty, 36:2864-2870, Aug. 2021
  DOI:10.1016/j.arth.2021.03.024
• Glucocorticoid-induced osteocytic cell death in a hypoxic environment is associated with necroptosis, Shusuke Ueda, Toru Ichiseki, Miyako Shimasaki, Hiroaki Hirata, Norio Kawahara, Yoshimichi Ueda, BioChem, 1:98-106, Aug. 2021
  DOI:10.3390/biochem1020009
• A novel minimally invasive spherical periacetabular osteotomy: pelvic ring preservation and patient-specific osteotomy by preoperative 3-dimensional templating, Ayumi Kaneuji, Toshihiko Hara, Eiji Takahashi, Kiyokazu Fukui, Toru Ichiseki, Norio Kawahara, The Journal of bone and joint surgery. American volume, 103:1724-1733, Sep. 2021
  DOI:10.2106/JBJS.20.00940
• Antibacterial fluorinated diamond-like carbon coating promotes osteogenesis—comparison with titanium alloy, Takeshi Sasamoto, Masahito Kawaguchi, Katsutaka Yonezawa, Toru Ichiseki, Ayumi Kaneuji, Kazuhiro Shintani, Anzu Yoshida, Norio Kawahara, Applied sciences (Basel), 11:9451, Oct. 2021
  DOI:10.3390/app11209451
• Catastrophic failure of cup revision hip arthroplasty due to undiagnosed paget disease of bone: a case report, Kiyokazu Fukui, Ayumi Kaneuji, Katsutaka Yonezawa, Akihiro Shioya,Toru Ichiseki, Norio Kawahara, International journal of surgery case reports, 76:5-10, Sep. 2020
  DOI:10.1016/j.ijscr.2020.09.101
• Taurine inhibits glucocorticoid-induced bone mitochondrial injury, preventing osteonecrosis in rabbits and cultured osteocytes, Hiroaki Hirata, Shusuke Ueda, Toru Ichiseki, Miyako Shimasaki, Yoshimichi Ueda, Ayumi Kaneuji, Norio Kawahara, International journal of molecular sciences, 21:6892, Sep. 2020
  DOI:10.3390/ijms21186892
• Mitochondrial transcription factor A added to osteocytes in a stressed environment has a cytoprotective effect, Shusuke Ueda, Miyako Shimasaki, Toru Ichiseki, Hiroaki Hirata, Norio kawahara, Yoshimichi Ueda, International journal of medical sciences, 17:1293-1299, May 2020
  DOI:10.7150/ijms.45335
• Dual mobility acetabular construct with freedom constrained liner for treatment of recurrent dislocations after total hip arthroplasty: A case report and literature review, Yuuki Onochi, Kiyokazu Fukui,, Ayumi Kaneuji, Toru Ichiseki, Xipeng Wang, Norio Kawahara, International journal of surgery case reports, 75:94-99, Sep. 2020
  DOI:10.1016/j.ijscr.2020.09.012
• Computed tomographic osteolytic analysis of a first-generation remelted highly cross-linked polyethylene in total hip arthroplasty-at a minimum of 15-year follow-up, Kiyokazu Fukui, Ayumi Kaneuji, Xipeng Wang, Toru Ichiseki, Tadami Matsumoto, Norio Kawahara, The Journal of arthroplasty, 35:1417-1423, May 2020
  DOI:10.1016/j.arth.2019.12.012
• Evaluation of antibacterial and cytotoxic properties of a fluorinated diamond-like carbon coating for the development of antibacterial medical implants, Katsutaka Yonezawa, Masahito Kawaguchi, Ayumi Kaneuji, Toru Ichiseki, Yoshitsugu Iinuma, Kae Kawamura, Kazuhiro Shintani, Shinobu Oda, Makoto Taki, Norio Kawahara, Antibiotics (Basel), 9:495, Aug. 2020
  DOI:10.3390/antibiotics9080495
• Right atrial fat emboli detection and changes in D-dimer values in reverse shoulder arthroplasty: a comparison with total hip arthroplasty, Shusuke Ueda, Toru Ichiseki, Daisuke Soma, Norio Kawahara, Archives of Medical Science - Civilization Diseases, 4:e84-e88, Aug. 2019
  DOI:10.5114/amscd.2019.87003
• Reverse shoulder arthroplasty for primary synovial osteochondromatosis of the shoulder with massive rotator cuff tear and marked degenerative arthropathy, Toru.Ichiseki, Shusuke.Ueda, Daisuke.Souma, Miyako.Shimasaki, Yoshimichi.Ueda, Norio.Kawahara, Journal of Clinical Medicine, 7:189, Jul. 2018
  DOI:10.3390/jcm7080189
• Mitochondrial stress and redox failure in steroid-associated osteonecrosis, Masanobu.Tsuchiya, Toru.Ichiseki, Shusuke.Ueda, Yoshimichi.Ueda, Miyako.Shimazaki, Ayumi.Kaneuji, Norio.Kawahara, International Journal of Medical Sciences, 15:205-209, Jan. 2018
  DOI:10.7150/ijms.22525
• Intraarticularly-injected mesenchymal stem cells stimulate anti-inflammatory molecules and inhibit pain related protein and chondrolytic enzymes in a monoiodoacetate-induced rat arthritis model, Toru.Ichiseki, Miyako.Shimasaki, Yoshimichi.Ueda, Shusuke.Ueda, Masanobu.Tsuchiya, Daisuke.Souma, Ayumi.Kaneuji, Norio.Kawahara, International Journal of Molecular Sciences, 19:203, Jan. 2018
  DOI:10.3390/ijms19010203
• Biomechanical behaviour of a French femoral component with thin cement mantle, Y.Numata, A.Kaneuji, L.Kerboull, E.Takahashi, T.Ichiseki, K.Fukui, J.Tsujioka, N.Kawahara, Bone & Joint Research, 7:485-493, Aug. 2018
  DOI:10.1302/2046-3758.77.BJR-2017-0288.R2
• The influence of cement thickness on stem subsidence and cement creep in a collarless polished tapered stem: When are thick cement mantles detrimental?, E.Takahashi, A.Kaneuji, R.Tsuda, Y.Numata, T.Ichiseki, K.Fukui, N.Kawahara, Bone & joint research, 6:351-357, May 2017
  DOI:10.1302/2046-3758.65.BJR-2017-0028.R1
• Massive tear of an ossified supraspinatus tendon: a case report and review of the literature, Toru.Ichiseki, Shusuke.Ueda, Ayumi.Kaneuji, Norio.Kawahara, International journal of clinical and experimental medicine, 10:1429-1433, Jan. 2017
• Involvement of necroptosis, a newly recognized cell death type, in steroid-induced osteonecrosis in a rabbit model, Toru.Ichiseki, Shusuke.Ueda, Yoshimichi.Ueda, Masanobu.Tuchiya, Ayumi.Kaneuji, Norio.Kawahara, International journal of medical sciences, 14:110-114, Jan. 2017
  DOI:10.7150/ijms.17134
• Prevention of glucocorticoid-associated osteonecrosis by intravenous administration of mesenchymal stem cells in a rabbit model, Shusuke.Ueda, Miyako.Shimasaki, Toru.Ichiseki, Yoshimichi.Ueda, Masanobu.Tsuchiya, Ayumi.Kaneuji, Norio.Kawahara, BMC musculoskeletal disorders, 18:480, Nov. 2017
  DOI:10.1186/s12891-017-1837-1
• The timing of glucocorticoid-induced osteocytic cell necrosis under hypoxia, S.Ueda, T.Ichiseki, Y.Ueda, A.Kaneuji, N.Kawahara, T.Matsumoto, International journal of clinical and experimental pathology, 9:7470-7475, Jul. 2016
• Bone remodeling after a mean of 10 years in diaphyseal cortical defects repaired with femoral revision using bypass fixation of extensively porous-coated stems with high stiffness, K.Fukui, A.Kaneuji, T.Sugimori, T.Ichiseki, T.Matsumoto, European Journal of Orthopaedic Surgery & Traumatology : OrthopéDie Traumatologie, 25:741-747, May 2015
• Age-related changes of mitochondrial transcription factor a expression in rotator cuff degeneration, T.Ichiseki, S.Ueda, Y.Ueda, A.Kaneuji, N.Kawahara, T.Matsumoto, American Journal of Translational Research, 7:2099-2104, Oct. 2015
• Osteocytic cell necrosis is caused by a combination of glucocorticoid-induced Dickkopf-1 and hypoxia, S.Ueda, T.Ichiseki, Y.Yoshitomi, H.Yonekura, Y.Ueda, A.Kaneuji, T.Matsumoto, Medical Molecular Morphology, 48:69-75, Jun. 2015
  DOI:10.1007/s00795-014-0077-9
• Rotational acetabular osteotomy for osteoarthritis with acetabular dysplasia: Conversion rate to total hip arthroplasty within twenty years and osteoarthritis progression after a minimum of twenty years, A.Kaneuji, T.Sugimori, T.Ichiseki, K.Fukui, E.Takahashi, T.Matsumoto, The Journal of bone and joint surgery. American volume, 97:726-732, May 2015
• Rare coexistence of gouty and septic arthritis after arthroscopic rotator cuff repair: a case report, T.Ichiseki, S.Ueda, T.Matsumoto, International Journal of Clinical and Experimental Medicine, 8:4718-4720, Mar. 2015
• Does rotational acetabular osteotomy affect subsequent total hip arthroplasty?, K.Fukui, A.Kaneuji, T.Sugimori, T.Ichiseki, T.Matsumoto, Archives of Orthopaedic and Trauma Surgery, 135:407-415, Mar. 2015
• Clinical assessment after total hip arthroplasty using the Japanese Orthopaedic Association Hip-Disease Evaluation Questionnaire, K.Fukui, A.Kaneuji, T.Sugimori, T.Ichiseki, T.Matsumoto, Y.Hiejima, Journal of Orthopaedics, 12:S31-S36, Feb. 2015
• Retrieval analysis of new-generation yttria-stabilized zirconia femoral heads after total hip arthroplasty, K.Fukui, A.Kaneuji, T.Sugimori, T.Ichiseki, T.Matsumoto, European journal of orthopaedic surgery & traumatology : orthopedie traumatologie., 24:1197-1202, Oct. 2014
• Cementless anatomic total hip femoral component with circumferential porous coating for hips with developmental dysplasia: a minimum ten-year follow-up period., A.Kaneuji, T.Sugimori, T.Ichiseki, K.Fukui, E.Takahashi, T.Matsumoto, The Journal of arthroplasty, 28:1746-1750, Dec. 2013
• Wear comparison between conventional and highly cross-linked polyethylene against a zirconia head: a concise follow-up, at an average 10 years, of a previous report., K.Fukui, A.Kaneuji, T.Sugimori, T.Ichiseki, T.Matsumoto, The Journal of arthroplasty, 28:1654-1658, Oct. 2013
• How far above the true anatomic position can the acetabular cup be placed in total hip arthroplasty?, K.Fukui, A.Kaneuji, T.Sugimori, T.Ichiseki, T.Matsumoto, Hip international : the journal of clinical and experimental research on hip pathology and therapy., 23:129-134, Mar. 2013
• The initial phase of oxidative stress in a steroid-induced osteonecrosis rabbit model, T.Ichiseki, A.Kaneuji, Y.Ueda, S.Kaneko, S.Ueda, T.Matsumoto, Advances in bioscience and biotechnology (Print), 3:978-982, Nov. 2012
• Japanese orthopaedic association hip disease evaluation questionnaire (JHEQ): a patient-based evaluation tool for hip-joint disease. The subcommittee on hip disease evaluation of the clinical outcome committee of the Japanese orthopaedic association, T.Matsumoto, A.Kaneuji, Y.Hiejima, H.Sugiyama, H.Akiyama, T.Atsumi, M.Ishii, K.Izumi, T.Ichiseki, H.Ito, T.Okawa, K.Ohzono, H.Otsuka, S.Kishida, S.Kobayashi, T.Sawaguchi, N.Sugano, I.Nakajima, S.Nakamura, Y.Hasegawa, K.Fukuda, G.Fujii, T.Mawatari, S.Mori, Y.Yasunaga, M.Yamaguchi, Journal of orthopaedic science : official journal of the Japanese Orthopaedic Association., 17:25-38, Jan. 2012
• The influence of femoroacetabular impingement after surgery for slipped capital femoral epiphysis, K.Fukui, A.Kaneuji, T.Sugimori, T.Ichiseki, T.Matsumoto, 30:153-157, Jul. 2011
• Osteonecrosis development in a novel rat model characterized by a single application of oxidative stress, T.Ichiseki, A.Kaneuji, Y.Ueda, S.Nakagawa, T.Mikami, K.Fukui, T.Matsumoto, Arthritis Rheum, 63:2138-2141, Jul. 2011
• A radiological study of the true anatomical position of the acetabulum in Japanese women, K.Fukui, A.Kaneuji, T.Sugimori, T.Ichiseki, T.Matsumoto, Hip international : the journal of clinical and experimental research on hip pathology and therapy., 21:311-316, Jun. 2011
• Should the well-fixed, uncemented femoral components be revised during isolated acetabular revision?, K.Fukui, A.Kaneuji, T.Sugimori, T.Ichiseki, K.Kitamura, T.Matsumoto, Archives of orthopaedic and trauma surgery., 131:481-485, Apr. 2011
• Wear comparison between a highly cross-linked polyethylene and conventional polyethylene against a zirconia femoral head : Minimum 5-year Follow-Up, K.Fukui, A.Kaneuji, T.Sugimori, T.Ichiseki, K.Kitamura, T.Matsumoto, The Journal of arthroplasty, 26:45-49, Jan. 2011
• Incidence of spondylolysis, spondylolisthesis and degenerative scoliosis of the lumbar spine in patients with terminal stage hip osteoarthritis, T.Okuda, T.Fujita, A.Kaneuji, E.Hatano, T.Ichiseki, Y.Yasuda, K.Fukui, T.Matsumoto, Journal of Spine Research, 1:1964-1967, Nov. 2010
• Prevention of steroid-induced osteonecrosis by intravenous administration of vitamin E in a rabbit model, T.Mikami, T.Ichiseki, A.Kaneuji, Y.Ueda, T.Sugimori, K.Fukui, T.Matsumoto, Journal of orthopaedic science : official journal of the Japanese Orthopaedic Association., 15:674-677, Sep. 2010
• Minimum ten-year results of a porous acetabular component for Crowe I to III hip dysplasia using an elevated hip center., A.Kaneuji, T.Sugimori, T.Ichiseki, K.Yamada, K.Fukui, T.Matsumoto, The Journal of arthroplasty, 24:187-194, Feb. 2009
• Oxidative stress on idiopathic osteonecrosis, T.Matsumoto, K.Kitamura, T.Ichiseki, A.Kaneuji, T.Sugimori, Clinical Calcium, 17:887-891, May 2007
• Oxidative stress may underlie the sex differences seen in steroid-induced osteonecrosis models, T.Ichiseki, T.Matsumoto, Medical hypotheses, 66:1256, Jun. 2006
• The relationship between stem subsidence and improvement in the radiolucency in polished tapered stems, A.Kaneuji, T.Sugimori, T.Ichiseki, K.Fukui, K.Yamada, T.Matsumoto, International orthopaedics., 30:387-390, May 2006
• Does oxidative stress play a role in steroid-induced osteonecrosis models?, T.Ichiseki, A.Kaneuji, K.Kitamura, T.Matsumoto, Medical hypotheses, 66:1048, May 2006
• Oxidative stress by glutathione depletion induces osteonecrosis in rats, T.Ichiseki, Y.Ueda, S.Katsuda, K.Kitamura, A.Kaneuji, T.Matsumoto, 45:287-290, Mar. 2006
• DNA oxidation injury in bone early after steroid administration is involved in the pathogenesis of steroid-induced osteonecrosis, T.Ichiseki, A.Kaneuji, S.Katsuda, Y.Ueda, T.Sugimori, T.Matsumoto, 44:456-460, Apr. 2005
• Oxidative stress and vascular permeability in steroid-induced osteonecrosis model, T. Ichiseki, *T. Matsumoto, *M. Nishino, *A. Kaneuji, S. Katsuda, Journal of orthopaedic science : official journal of the Japanese Orthopaedic Association., 9：509-515, 2004
• Radiographic evaluation and changes in bone density of the humeral side after reverse total shoulder arthroplasty, Daisuke Soma, Toru Ichiseki, Shusuke Ueda, Masaru Sakurai and Norio Kawahara, Journal of Clinical Medicine, 12:7698, Dec. 2023
  DOI:10.3390/jcm12247698

Awards & Honors

• Oct. 2018 The Japan Shoulder Society Annual Meeting 2018 Award-Winning Abstracts Intraarticularlr injected mesenchymal stem cells stimulate anti-inflammatory molecules and inhibit pain and chondrolytic enzymes in a rat model of arthritis
  Toru Ichiseki, Shusuke Ueda, Daisuke Souma, Miyako Shimasaki, Yoshimichi Ueda, Norio Kawahara