NAKAHASHI Takeshi

■FacultyDepartment of General Internal Medicine
■PositionProfessor

Researcher Profile & Settings

Research

    Overview of research:
    Geriatrics, Circulation, Hypertension, Atherosclerosis, Cardiology

Special Field

  • Cardioangiology
  • Wide Area

Education

  • Osaka University Graduate School
  • Osaka University Faculty of Medicine

Degree

  • Ph.D in Medicine

Association Memberships

  • 1997Japan Circulation Society
  • 1997The Japan Geriatrics Society
  • 1998American Heaert Association Premium Professonal Member

Academic & Professional Experience

  • Jul. 1998- Jun. 2000Maryland Research Laboratories Visiting Scientis
  • Jul. 2000- Mar. 2002Stanford University Department of Vascular Surgery Research Fellow
  • Apr. 2002Kanazawa Medical University, Department of Geriatric Medicine Assistant Professor
  • Jun. 1990- Jun. 1991Osaka University Hospital Resident
  • Jul. 1991- Dec. 1992Osaka-Minami National Hospital, Department of Cardiology Resident
  • Jan. 1993- May 1993Osaka-Minami National Hospital, Department of Gastroenterology Resident
  • Jun. 1993- Mar. 1995Osaka University Medical School, Department of Geriatric Medicine Research Fellow
  • Apr. 1995- Jun. 1998Osaka University Medical School, Department of Geriatric Medicine Medical Staff

Research Activities

Published Papers

  • A new predictive tool consolidating CURB-65 with procalcitonin and albumin to assess short-term mortality in hospitalized elderly patients with infectious disease: A retrospective study of a patient cohort, Toshihiro Higashikawa, Tomohiko Ito, Takuro Mizuno, Keiichirou Ishigami, Kengo Kuroki, Naoto Maekawa, Daisuke Usuda, Shinichiro Nakao, Kazu Hamada, Susumu Takagi, Nao Terada, Kento Takeshima, Shinya Yamada, Ryusho Sangen, Toshihide Izumida, Jun Kiyosawa, Atsushi Saito, Masaharu Iguchi, Hiroyuki Wato, Takeshi Nakahashi, Yuji Kasamaki, Akihiro Fukuda, Tsugiyasu Kanda, Masashi Oku, Medicine, 101:e31614., Nov. 2022
  • The Impact of Tofogliflozin on Physiological and Hormonal Function, Serum Electrolytes, and Cardiac Diastolic Function in Elderly Japanese Patients with Type 2 Diabetes Mellitus, Toshihiro Higashikawa, Tomohiko Ito, Takurou Mizuno, Keiichiro Ishigami, Kengo Kuroki, Naoto Maekawa, Daisuke Usuda, Toshihide Izumida, Shinya Yamada, Ryusho Sangen, Kazu Hamada, Jun Kiyosawa, Atsushi Saito, Masaharu Iguchi, Yuji Kasamaki, Takeshi Nakahashi, Akihiro Fukuda, Hitoshi Saito, Tsugiyasu Kanda, Masashi Okuro, Acta Medica Okayama, 76:705-713, Dec. 2022
  • Postoperative Urinary Retention in Japanese Elderly Males with a Femoral Neck or Trochanteric Fracture, Toshihiro Higashikawa, Kenji Shigemoto, Kenichi Goshima, Shintarou Iwai, Manabu Moriyama, Daisuke Usuda, Masahiro Hangyou, Hiromi Inujima, Kakeru Nozaki, Miyako Yamaguchi, Kimiko Usuda, Takeshi Nakahashi, Tadami Matsumoto, Shigeki Takashima, Tsugiyasu Kanda, Takeshi Horii, Masashi Okuro, Takeshi Sawaguchi, Acta Medica Okayama, 76:409-414, Aug. 2022
  • Effects of tofogliflozin on adrenocorticotropic hormone, renin and aldosterone, and cortisol levels in elderly patients with diabetes mellitus: A retrospective study of a patient cohort, Toshihiro Higashikawa, Tomohiko Ito, Takurou Mizuno, Keiichirou Ishigami, Kengo Kuroki, Naoto Maekawa, Daisuke Usuda, Takuro Morita, Kazu Hamada, Susumu Takagi, Kento Takeshima, Shinya Yamada, Ryusho Sangen, Toshihide Izumida, Hideyuki Mori, Jun Kiyosawa, Atsushi Saito, Masaharu Iguchi, Takeshi Nakahashi, Yuji Kasamaki, Akihiro Fukuda, Tsugiyasu Kanda, Masashi Okuro, Medicine, 100:e27638, Nov. 2021
  • The 12-Month Administration of Tofogliflozin for Glycemic Control with Monitoring Electrolytes, Renal and Cardiac Function in Japanese Elderly Patients with Type 2 Diabetes Mellitus, Toshihiro Higashikawa, Tomohiko Ito, Takurou Mizuno, Keiichiro Ishigami, Masaru Kohori, Kunihiro Mae, Daisuke Usuda, Kazu Hamada, Takuro Morita, Kento Takeshima, Susumu Takagi, Toshihide Izumida, Kengo Kuroki, Ryusho Sangen, Atsushi Saito, Masaharu Iguchi, Yuji Kasamaki, Takeshi Nakahashi, Akihiro Fukuda, Tsugiyasu Kanda, Masashi Okuro, International Journal of Geriatrics and Gerontology, 5:1-8, Feb. 2021
  • Gender Differences in Cardiac Function Following Three-Month Administration of Tofogliflozin in Patients With Diabetes Mellitus, Toshihiro Higashikawa, Tomohiko Ito, Takurou Mizuno, Keiichiro Ishigami, Masaru Kohori, Kunihiro Mae, Daisuke Usuda, Kento Takeshima, Susumu Takagi, Toshihide Izumida, Shinya Yamada, Kengo Kuroki, Ryusho Sangen, Atsushi Saito, Masaharu Iguchi, Yuji Kasamaki, Takeshi Nakahashi, Akihiro Fukuda, Tsugiyasu Kanda, Masashi Okuro, Journal of Clinical Medicine Research, 12:530-538, Aug. 2020
  • Genetic factors associated with elevation of uric acid after treatment with thiazide-like diuretic in patients with essential hypertension, Ohta Y, Kamide K, Hanada H, Morimoto S, Nakahashi T, Takiuchi S, Ishimitsu T, Tsuchihashi T, Soma M, Tomohiro Katsuya T, Sugimoto K, Rakugi H, Oukura T, Higaki J, Matsuura H, Shinagawa T, Miwa Y, Sasaguri T, Igase M, Miki T, Takeda K, Higashiura K, Shimamoto K, Katabuchi R, Ueno M, Hosomi N, Kato J, Komai N, Kojima S, Sase K, Iwashima Y, Yoshihara F, Horio T, Nakamura S, Nakahama H, Miyata T, Kawano Y, Hypertension Research, 43:220-226, Mar. 2020
  • Neuroinflammation, Oxidative Stress, and Neurogenesis in a Mouse Model of Chronic Fatigue Syndrome, and the Treatment with Kampo Medicine, He, Qiang;Sawada, Mio;Yamasaki, Naruhiro;Akazawa, Sumiyo;Furuta, Hisakazu;Uenishi, Hiroaki;Meng, Xiangjin;Nakahashi, Takeshi;Ishigaki, Yasuhito;Moriya, Junji, BIOLOGICAL & PHARMACEUTICAL BULLETIN, 43:110-115, Jan. 2020
  • Genetic factors associated with elevation of uric acid after treatment with thiazide-like diuretic in patients with essential hypertension., Ohta Yuko;Kamide Kei;Hanada Hironori;Morimoto Shigeto;Nakahashi Takeshi;Takiuchi Shin;Ishimitsu Toshihiko;Tsuchihashi Takuya;Soma Masayoshi;Tomohiro Katsuya T;Sugimoto Ken;Rakugi Hiromi;Oukura Takafumi;Higaki Jitsuo;Matsuura Hideo;Shinagawa Tatsuo;Miwa Yosikazu;Sasaguri Toshiyuki;Igase Michiya;Miki Tetsuro;Takeda Kazuo;Higashiura Katsuhiro;Shimamoto Kazuaki;Katabuchi Ritsuko;Ueno Michio;Hosomi Naonaga;Kato Johji;Komai Norio;Kojima Shunichi;Sase Kazuhiro;Iwashima Yoshio;Yoshihara Fumiki;Horio Takeshi;Nakamura Satoko;Nakahama Hajime;Miyata Toshiyuki;Kawano Yuhei, Hypertension research : official journal of the Japanese Society of Hypertension, 43, 2020
  • Neuroinflammation, Oxidative Stress, and Neurogenesis in a Mouse Model of Chronic Fatigue Syndrome, and the Treatment with Kampo Medicine, He Qiang;Moriya Junji;Sawada Mio;Yamasaki Naruhiro;Akazawa Sumiyo;Furuta Hisakazu;Uenishi Hiroaki;Meng Xiangjin;Nakahashi Takeshi;Ishigaki Yasuhito, Biological and Pharmaceutical Bulletin, 43:110-115, 2020
  • Neuroinflammation, Oxidative Stress, and Neurogenesis in a Mouse Model of Chronic Fatigue Syndrome, and the Treatment With Kampo Medicine, Qiang He, Mio Sawada, Naruhiro Yamasaki, Sumiyo Akazawa, Hisakazu Furuta, Hiroaki Uenishi, Xiangjin Meng, Takeshi Nakahashi, Yasuhito Ishigaki, Junji Moriya, Biological & pharmaceutical bulletin, 43:110-115, 2020
  • Comorbidity of chronic kidney disease, diabetes and lower glycated hemoglobin predicts support/care-need certification in community-dwelling older adults., Watanabe Keisuke;Okuro Masashi;Okuno Tazuo;Iritani Osamu;Yano Hiroshi;Himeno Taroh;Morita Takuro;Igarashi Yuta;Nakahashi Takeshi;Morimoto Shigeto, Geriatrics & Gerontology International, 18:521-529, Apr. 2018
  • Genome-wide response to antihypertensive medication using home blood pressure measurements: a pilot study nested within the HOMED-BP study., (Y.Imai), S.Morimoto, T.Nakahashi, GEANE study group & HOMED-BP study group, Pharmacogenomics, 14:1709-1721, 2013
  • Sleep apnoea syndrome as a risk for mortality in elderly inpatients, S.Morimoto, T.Takahashi, K.Okaishi, M.Okuro, T.Nakahashi, D.Sakamoto, T.Mizuno, T.Kanda, M.Takahashi, H.Toga, The Journal of international medical research., 40:601-611, 2012
  • Mao-to prolongs the survival of and reduces TNF-α expression in mice with viral myocarditis, Z.Shijie, J.Moriya, J.Yamakawa, R.Chen, T.Takahashi, H.Sumino, T.Nakahashi, K.Iwai, S.Morimoto, N.Yamaguchi, T.Kanda, Evidence-based complementary and alternative medicine : eCAM., 7:341-349, 2010
  • Silent information regulator, sirtuin 1, and age-related diseases, L.Zeng, R.Chen, F.Liang, H.Tsuchiya, H.Murai, T.Nakahashi, K.Iwai, T.Takahashi, T.Kanda, S.Morimoto, Nature clinical practice. Rheumatology., 9:7-15, 2009
  • Candesartan improves myocardial damage in obese mice with viral myocarditis and induces cardiac adiponectin, F.Yu, R.Chen, T.Takahashi, H.Sumino, S.Morimoto, T.Nakahashi, K.Iwai, M.Matsumoto, T.Kanda, International journal of cardiology, 129:414-421, Nov. 2008
  • Association between seroprevalence of human metapneumovirus and c-reactive protein level and apolipoprotein e-ε4 allele in elderly inpatients in Japan, T.Takahashi, K.Nomura, H.Honda, T.Nakahashi, K.Iwai, M.Atsumi, K.Ishigami, T.Inamatsu, S.Morimoto, Journal of the American Geriatrics Society., 56:1758-1760, Sep. 2008
  • Association seroprevalence of human metapneumovirus with small vessel disease with dementia in elderly inpatients in Japan, K.Nomura, H.Murai, T.Nakahashi, H.Tsuchiya, K.Iwai, S.Morimoto, 33:86-90, Aug. 2008
  • Outbreak of norovirus gastroenteritis in elderly evacuees after the 2007 Noto peninsula earthquake in Japan, K.Nomura, H.Murai, T.Nakahashi, S.Mashiba, Y.Watoh, T.Takahashi, S.Morimoto, Journal of the American Geriatrics Society., 56:361-363, Feb. 2008
  • Immobilization stress inhibits intimal fibromuscular proliferation in the process of arterial remodeling in rats, K.Iwai, T.Takahashi, T.Nakahashi, K.Nomura, M.Atsumi, L.Zeng, K.Ishigami, T.Kanda, N.Yamaguchi, S.Morimoto, Hypertension research : official journal of the Japanese Society of Hypertension., 31:977-986, 2008
  • Reduced-energy diet improves survival of obses KKAy mice with viral myocarditis:induction of cardiac adiponectin expression, T.Kanda, S.Saegusa, T.Takahashi, H.Sumino, S.Morimoto, T.Nakahashi, K.Iwai, M.Matsumoto, International journal of cardiology, 119:310-318, Jul. 2007
  • Oral administration of candesartan improves the survival of mice with viral myocarditis through modification of cardiac adiponectin expression, S.Saegusa, Y.Fei, T.Takahashi, H.Sumino, J.Moriya, K.Kawaura, J.Yamakawa, T.Itou, S.Morimoto, T.Nakahashi, K.Iwai, M.Matsumoto, T.Kanda, Cardiovascular drugs and therapy / sponsored by the International Society of Cardiovascular Pharmacotherapy., 21:155-160, Jun. 2007
  • Hepatocyte growth factor and visfatin in elderly bedridden patients, T.Kanda, T.Takahashi, H.Sumino, T.Nakahashi, K.Iwai, S.Morimoto, M.Matsumoto, Journal of the American Geriatrics Society., 55:963-965, Jun. 2007
  • The Japanese guidelines of the prevention and treatment of osteoporosis (2006 edition)(abridged), S.Morimoto, T.Nakahashi, H.Orimo, Osteoporosis Japan = Osuteopor？shisu Japan., 15:351-355, Apr. 2007
  • Tilting-induced decrease in systolic blood pressure in bedridden hypertensive elderly inpatients:effects of azelnidipine, S.Morimoto, T.Takahashi, K.Okaishi, T.Nakahashi, K.Nomura, T.Kanda, M.Okuro, H.Murai, T.Nishino, M.Matsumoto, Hypertension research : official journal of the Japanese Society of Hypertension., 29:943-949, Dec. 2006
  • Angiotensin Ⅰ-converting enzyme inhibitor improves reactive hyperemia in elderly hypertensives with arteriosclerosis obliterans, M.Okuro, S.Morimoto, T.Takahashi, K.Okaishi, T.Nakahashi, H.Murai, K.Iwai, T.Kanda, Hypertension research : official journal of the Japanese Society of Hypertension., 29:655-663, Sep. 2006
  • A ninety-eight-year-old woman with ruptured pancreatic anaplastic mucinous cystadenocarcinoma, H.Murai, S.Morimoto, I.Ohashi, K.Okaishi, H.Tsuchiya, K.Iwai, T.Nakahashi, Y.Nishimura, M.Okuro, E.Miyauchi, T.Nojima, M.Matsumoto, 43：246-251, Feb. 2006
  • A ninety-eight-year-old woman with ruptured pancreatic anaplastic mucinous cystadenocarcinoma, 43:246－251, Feb. 2006
  • Impaired expression of cardiac adiponectin in leptin-deficient mice with viral myocarditis, T.Takahashi, F.Yu, S.Saegusa, H.Sumino, T.Nakahashi, K.Iwai, S.Morimoto, M.Kurabayashi, T.Kanda, International Heart Journal, 47:107-123, Jan. 2006
  • Wall shear stress and strain modulate experimental aneurysm cellularity, Journal of vascular surgery : official publication, the Society for Vascular Surgery [and] International Society for Cardiovascular Surgery, North American Chapter., 37:1067-74, May 2003
  • Flow loading induces macrophage aneioxidative gene expression Experimental Aneurysms, NAKAHASHI Takeshi, Arteriosclerosis, thrombosis, and vascular biology., 22:2017-22, Dec. 2002
  • Flow loading induces macrophage aneioxidative gene expression Experimental Aneurysms, NAKAHASHI Takeshi, Arteriosclerosis, thrombosis, and vascular biology., 22:2017-22, Dec. 2002
  • Brain-derived neurotrophic factor is stored in human platelets and released by agonist stimulation, Thromb Haemost, 87:728-34, Apr. 2002
  • Platelets in nonresponders to epinephrine stimulation showed reducal response to ADP, NAKAHASHI Takeshi, Thrombosis Research, 104:127-35, Oct. 2001
  • Platelets in nonresponders to epinephrine stimulation showed reducal response to ADP, NAKAHASHI Takeshi, Thrombosis Research, 104:127-35, Oct. 2001
  • Vascular endothelial cells synthesize and secrete brain-derived neurotrophic factor, NAKAHASHI Takeshi, FEBS Letters, 470:113-7, Mar. 2000
  • Vascular endothelial cells synthesize and secrete brain-derived neurotrophic factor, NAKAHASHI Takeshi, FEBS Letters, 470:113-7, Mar. 2000
  • Multicenter prospective survey of prognosis of hypertensive elderly outpatient under antihypertensive treatment--morbidity and mortality of cardiovascular diseases and cancer, 36:342-351, May 1999
  • Hydrogen peroxide induces up-regulation of fas in human endothelial cells, Immunology., 160:4042-4047, Apr. 1998
  • Exogenous ouabain is accumulated in the adrenals and mimics the kinetics of endogenous digitalis-like factor in rats, Hypertension research : official journal of the Japanese Society of Hypertension., 21:47-56, Mar. 1998
  • Endothelin-1 enhances nitric oxide-induced cell death in cultured vascular smooth muscle cells, Journal of cardiovascular pharmacology., 31:S351-353, 1998
  • Interleukin-2 modulates the responsiveness to angoitensin II in cultured vascular smooth muscle cells, Atherosclerosis., 133:23-30, Aug. 1997
  • Angiotensin Receptor, 55:S2,546-8, Apr. 1997
  • Possible participation of Fas-mediated apoptosis in the mechanism of atherosclerosis, Gerontology., 43:35-42, 1997
  • Parathyroid hormore-related protein inhibits endothelin-1 production, Hypertension., 27:360-363, Mar. 1996
  • Nitric oxide induces upregulation of Fas and apoptosis in vascular smooth muscle, Hypertension., 27:823-826, Mar. 1996
  • Calcitonin prevents CCl4-induced hydroperoxide generation and cytotoxicity possibly through C1b receptor in rat hepatocytes, Biochemical and Biophysical Research Communication, 218:865-871, Jan. 1996
  • A case of renovascular hypertension with marked polyuria after percutaneous transluminal renal angioplasty, Nephron., 73:79-85, Jan. 1996
  • cGMP upregulates nitric oxide synthase expression in vascular smooth muscle cells, Hypertension., 25:711-714, Apr. 1995
  • Endothelin-1 enhances nitric oxide-induced cytotoxicity in vascular smooth muscle cells, Hypertension., 25:744-747, Apr. 1995
  • Nitric oxide mediates cytotoxicity and basic fibroblast growth factor release in cultured vascular smooth muscle cells. A possiblemechanism of neovascularizaion in atherosclerotic plaques, J. Clin. Invest., 95:669-676, Feb. 1995
  • Relation between low serum cholesteryl-ester transfer activity and abdominal aortic calcification in normolipidemic elderly subjects, Archives of Gerontology and Geriatrics, 16:9-15, Jan. 1994
  • Effect of ipriflavone on bone mineral density and calcium-related factors in elderly females, Calcified Tissue International, 51:30-34, 1992
  • Circulating suppressing factor for the muscarinic acetylcholine receptor in patients with senile dementia of the Alzheimer type, Gerontology., 8:24-28, 1992
  • Adhesion behavior of rat lymphocytes to poly(ether)-poly(amino acid) block and graft copolymers, J Biomed Mater Res, 20:867-78, Sep. 1986
  • Orthogeriatric co-management at a regional core hospital as a new multidisciplinary approach in Japanese hip fracture operation, Toshihiro Higashikawa, Kenji Shigemoto, Manabu Moriyama, Daisuke Usuda, Masahiro Hangyou, Hiromi Inujima, Kakeru Nozaki, Miyako Yamaguchi, Kimiko Usuda, Osamu Iritani, Shigeto Morimoro, Takeshi Horii, Takeshi Nakahashi, Tadami Matsumoto, Toga Hirohisa, Shigeki Takashima, Tsugiyasu Kanda, Masashi Okuro, Takeshi Sawaguchi, Journal of Orthopaedic Science, 29:273-277, Jan. 2024