MOTOO Yoshiharu

Researcher Profile & Settings

Research

Overview of research:
1. Cellular biological analysis on pancreatic stress proteins in human pancreatic cancer cells will clarify the significance of these proteins. 2. Relationship between the regulation of sphingolipid-related enzymes such as sphingomyelin synthase and pancreatic carcinogenesis has been analyzed. 3. Efficacy and safety of Kampo medicines in attenuation of adverse effects of cancer treatments such as chemotherapy is being verified in clinical trials.

Special Field

• Digestive organs internal medicine

Education

• Tokyo Medical and Dental University Faculty of Medicine

Degree

• Ph.D in Medicine

Academic & Professional Experience

• May 1984- Mar. 1986Wadley Institutes of Molecular Medicine Researcher

Research Activities

Published Papers

• Factors associated with severe skin disorder after extravasation of intravenously infused antineoplastic agents, Yuko.Matsui,, Ryoko.Murayama, Hidenori.Tanabe, Makoto.Oe, Yoshiharu.Motoo, Takanori.Wagatsuma, Michiko.Michibuchi, Sachiko.Kinoshita, Keiko.Sakai, Chizuko.Konya, Junko.Sugama, Hiromi.Sanada, Journal of Nursing Science and Engineering, 5:31-40, 2018
• Ramucirumab plus paclitaxel: a possible new chemotherapy regimen for neuroendocrine carcinoma of the stomach, Motoo Y, Internal Medicine, 57:631-632, Mar. 2018
  DOI:doi: 10.2169/internalmedicine.9709-17.
• In vivo imaging xenograft models for the evaluation of anti-brain tumor efficacy of targeted drugs, (Kita.Kenji), Arai.Sachiko, Nishiyama. Akihiro, Taniguchi. Hirokazu, Fukuda.Koji, Wang.Rong,Yamada.Tadaaki,Takeuchi.Shinji, Tange. Shoichiro,Tajima. Atsushi, Nakada. Mitsutoshi,Yasumoto. Kazuo, Motoo.Yoshiharu, Murakami.Takashi, Yano.Seiji, Cancer Medicine, 6:2972-2983, Dec. 2017
  DOI:10.1002/cam4.1255
• Evaluation of the predictive validity of thermography in identifying extravasation with intravenous chemotherapy infusions, Yuko.Matsui, Ryoko.Murayama, Hidenori.Tanabe, Makoto.Oe, Yoshiharu.Motoo, Takanori.Wagatsuma, Michiko.Michibuchi, Sachiko.Kinosita, Keiko.Sakai, Chizuko.Konya, Junko.Sugama, Hiromi.Sanada, Journal of Infusion Nursing, 40:367-374, Nov. 2017
• Long-term survival due to combination therapy in a patient with locally advanced body-tall pancreatic cancer, Nobuhiko.Ueda, Yoritaka.Fujii, Seiko.Miura, Jun. Fujita, Yasuto.Tomita, Toshio.Ohnishi, Hideto.Fujita, Shinichi.Kinami, Kazuhiko.Omote, Yasuharu.Nakano, Takeo.Kosaka, Yoshiharu.Motoo, Japanese Journal of Cancer and Chemotherapy, 44:1373-1375, Nov. 2017
• Effect of ninjin'yoeito and ginseng extracts on oxaliplatin-induced neuropathies in mice, (Suzuki.Toshiaki), Yamamoto. Ayano, Ohsawa.Masahiro, Motoo. Yoshiharu, Mizukami. Hajime, Makino.Toshiaki, Journal of Natural Medicines, 71:757-764, Oct. 2017
  DOI:10.1007/s11418-017-1113-6
• Standards of reporting Kampo products (STORK) in research articles, Y Motoo,T Hakamatsuka,N Kawahara,I AraiI,K Tsutani., Journal of Integrative Medicine, 15:182-185, Apr. 2017
• Economic burden and mental distress in using complementary and alternative medicine, and formal supports by medical professional of japanese patients with chronic diseases, Keiko.Yukawa, Hirono.Ishikawa, Yoshihiko.Yamazaki, Jimpei.Misawa, Kiichiro.Tsutani, Ichiro.Arai, Yoshiharu.Motoo, Takahiro.Kiuchi, Japanese Pharmacology & Therapeutics, 45:345-355, Feb. 2017
• Clinical study on the efficacy and continuous docetaxel based chemotherapy treatment for castration-resistant prostate cancer, Ippei.Chikazawa, Shinya.Inoue, Yusuke.Nakazawa, Dan.Nakai, Nobuyo.Morita, Tatsuro.Tanaka, Yoshiharu.Motoo and Katsuhito.Miyazawa, 63:351-357, 2017
• Identification and functional analysis of an EMT-accelerating factor induced in pancreatic cancer cells by an anticancer agent, T.Shimasaki, S.Yamamoto, Y.Ishigaki, T.Takata, T.Arisawa, Y.Motoo, N.Tomosugi, T.Minamoto, Suizo, 31:76-84, 2016
• Description of Kampo medicines in the clinical practice guidelines for irritable bowel syndrome, Y.Motoo, Journal of Gastroenterology, 50:816-816, Jul. 2015
  DOI:10.1007/s00535-015-1075-y
• Ninjin'yoeito and ginseng extract prevent oxaliplatin-induced neurodegeneration in PC12 cells, (T.Suzuki), A.Yamamoto, M.Ohsawa, Y.Motoo, H.Mizukami, T.Makino, Journal of Natural Medicines, 69:531-537, 2015
  DOI:10.1007/s11418-015-0921-9
• Survey on health hazards indirectly caused by complementary and alternative medicine in Japan, (K.Tsutani), K.Yukawa, M.Nagasawa, I.Arai, A.Igarashi, H.Ogasawara, K.Tsuruoka, S.Fukuyama, Y.Motoo, Y.Yamazaki, 42:1005-1014, Dec. 2014
• Effect of saikokeishito, a kampo medicine, on hydrogen peroxide-induced premature senescence of normal human dermal fibroblasts, T. Takata, Y. Motoo, N. Tomosugi, Journal of integrative medicine., 12:495-503, Nov. 2014
• Treatment with kampo medicines fo reflex sympathetic dystrophy, post-optic nerve meningioma operation and traffic injury, J.Moriya, J.Yamakawa, K.Takeuchi, Y.Motoo, J.Kobayashi, 24:144-148, May 2014
• Analysis of thermographic images in an extravasation model of intravenous infusion in healthy adults, Y.Matsui, R.Murayama, H.Tanabe, M.Oe, M.Fukuda, Y.Motoo, T.Wagatsuma, S.Kinoshita, K.Sakai, C.Konya, J.Sugama, H.Sanada, 1:4-11, Apr. 2014
• Successful treatment of post-influenza chronic fatigue syndrome with kampo medicine:a case report, J.Moriya, K.Takeuchi, H.Uenishi, S.Akazawa, Y.Motoo, H.Hashimoto, M.Kaneshima, J.Kobayashi, J.Yamakawa, 65:87-93, Feb. 2014
• Whole Person Care, 60:93-94, Jan. 2014
• Use of Kampo diagnosis in randomized controlled trials of Kampo products in Japan: a systematic review, Y.Motoo, I.Arai, K,Tsutani, PloS one, 9:e104422;1-9, 2014
• Acupuncture and herbal medicine for cancer patients 2014, (T.Efferth), S.Lee, Y.Motoo, S.Schroder, Evidence-based complementary and alternative medicine : eCAM., 2014,326179;1-2, 2014
• A case of leg pain associated with lumber spinal canal stenosis in patient with Parkinson disease treated by yokukansan., J.Moriya, J.Yamakawa, K.Takeuchi, Y.Motoo, 23:114-117, May 2013
• Significance of kampo, japanese traditional medicine, in the treatment of obesity:basic and clinical evidence., J.Yamakawa, J.Moriya, K.Takeuchi, M.Sawada, Y.Motoo, J.Kobayashi, Evidence-based complementary and alternative medicine : eCAM., 2013,943075;1-8, Mar. 2013
• Significance of Kampo, traditional Japanese medicine, in supportive care of cancer patients., J.Yamakawa, Y.Motoo, J.Moriya, M.Ogawa, H.Uenishi, S.Akazawa, T.Sasagawa, M.Nishio, J.Kobayashi, Evidence-based complementary and alternative medicine : eCAM., 2013,746486;1-10, Mar. 2013
• Role of Kampo medicine in integrative cancer therapy., J.Yamakawa, Y.Motoo, J.Moriya, M.Ogawa, H.Uenishi, S.Akazawa, T.Sasagawa, M.Nishio, J.Kobayashi, Evidence-based complementary and alternative medicine : eCAM., 2013:570848;1-6, Mar. 2013
• Neuroendcrine carcinoma of the prostate treated combined modality therapy., I.Chikazawa, D.Nakai, K.Miyazawa, T.Tanaka, K.Suzuki, K.Sato, Y.Motoo, 59：99-104, Feb. 2013
• Aberrant glycogen synthase kinase 3β is involved in pancreatic cancer cell invasion and resistance to therapy., (A.Kitano), T.Shimasaki, Y.Chikano, M.Nakada, M.Hirose, T.Higashi, Y.Ishigaki, Y.Endo, T.Takino, H.Sato, Y.Sai, K.Miyamoto, Y.Motoo, K.Kawakami, T.Minamoto, PloS one, 8:e55289;1-12, Feb. 2013
• Meaning of tumor protein 53-induced nuclear protein 1 in the molecular mechanism of gemcitabine sensitivity., N.Nakaya, Y.Ishigaki, H.Nakajima, M.Murakami, T.Shimasaki, T.Takata, M.Ozaki, NJ.Dusetti, JL.Iovanna, Y.Motoo, Molecular and clinical oncology., 1:100-104, Jan. 2013
• Efficacy and safety of bortezomib plus dexamethasone therapy for refractory or relapsed multiple myeloma: once-weekly administration of bortezomib may reduce the incidence of gastrointestinal adverse events, T.Fukushima, T.Nakamura, H.Iwao, A.Nakajima, M.Miki, T.Sato, T.Sakai, T.Sawaki, Y.Fujita, M.Tanaka, Y.Masaki, H.Nakajima, Y.Motoo, H.Umehara, Anticancer research., 31:2297-2302, Sep. 2011
• A Case of primary cardiac angiosarcoma associated with cardiac tamponade, N.Nakaya, I.Sato, T.Shimasaki, H.Nakajima, N.Kurose, T.Nojima, Y.Motoo, 38:1353-1355, Aug. 2011
• Traditional Japanese medicine, Kampo: Its history and current status, Y.Motoo, T.Seki, K.Tsutani, Chinese journal of integrative medicine, 17:85-87, Feb. 2011
• Metabolic disorder, inflammation, and deregulated molecular pathways converging in pancreatic cancer development: Implications for new therapeutic strategies, Y.Motoo, T.Shimasaki, Y.Ishigaki, H.Nakajima, K.Kawakami, T.Minamoto, Cancers, 3:446-460, Jan. 2011
• Human SMG-1 is involved in gemcitabine-induced primary microRNA-155/BIC up-regulation in human pancreatic cancer PANC-1 cells, (QS.Xia), Y.Ishigaki, X.Zhao, T.Shimasaki, H.Nakajima, H.Nakagawa, T.Takegami, ZH.Chen, Y.Motoo, Pancreas., 40:55-60, Jan. 2011
• Combination chemotherapy of docetaxel and uft against hormone refractory prostate cancer, T.Shimasaki, K.Miyazawa, M.Moriyama, T.Tanaka, I.Sato, N.Nakaya, H.Nakajima, A.Kubo, K.Suzuki, Y.Motoo, 57:163-166, 2011
• Scanning electron microscopy with an ionic liquid reveals the loss of mitotic protrusions of cells during the epithelial-mesenchymal transition, Y.Ishigaki, Y.Nakamura, T.Takehara, T.Shimasaki, T.Tatsuno, F.Takano, Y.Ueda, Y.Motoo, T.Takegami, H.Nakagawa, S.Kuwabata, N.Nemoto, N.Tomosugi, S.Miyazawa, Microscopy research and technique, 74:1024-1031, 2011
• Epithelial- to- mesenchymal transition in pancreatic adenocarcinoma, (C.Cano), Y.Motoo, JL.Lovanna, The Scientific World Journal, 10:1947-1957, Oct. 2010
• Curatively resected case of non-functioning pancreatic neuroendocrine carcinoma with multiple liver metasta-ses after dpwmstaging with S-1 monotherapy, I.Sato, N.Ueda, E.Kinoshita, H.Mnato, K.Ohno, N.Nakata, T.Shimasaki, H.Nakajima, T.Kosaka, Y.Motoo, 37:1341-1344, Jul. 2010
• A case of carpal tunnel syndrome treated by the combination with san'oshashinto and tokakujokito, J.Moriya, J.Yamakawa, Y.Motoo, 20:81-83, Jun. 2010
• Two cases of atypical adenoma of the thyroid―is atypical adenoma of the thyroid a true benign lesion?―, (M.Tachibana), Y.Hashimoto, T.Sone, N.Ooishi, T.Ueno, Y.Motoo, 49:190-195, Mar. 2010
• Application of molecular medicine to pancreatic cancer, T.Shimasaki, Y.Ishigaki, T.Minamoto, Y.Motoo, 25:35-45, Jan. 2010
• A Kampo medicine, boiogito, inhibits obesity in ovariectomized rats, J.Yamakawa, J.Moriya, T.Takahashi, A.Ishige, Y.Motoo, F.Yoshizaki, T.Kanda, Evidence-based complementary and alternative medicine : eCAM., 7:87-95, Jan. 2010
• Molecular analysis on responses of TP53INP1-knockout mouse embryonic fibroblasts to anti-cancer agents, (Q.Bian), Y.Motoo, H.Nakajima, T.Shimasaki, Y.Ishigaki, 125-128, 2010
• Induction of HITS, a newly identified family with sequence similarity 107 protein (FAM107B), in cancer cells by heat shock stimulation, H.Nakajima, Y.Ishigaki, QI-S.Xia, T.Ikeda, Y.Yoshitake, H.Yonekura, T.Nojima, T.Tanaka, H.Umehara, N.Tomosugi, T.Takata, T.Shimasaki, N.Nakaya, I.Sato, K.Kawakami, K.Koizumi, T.Minamoto, Y.Motoo, International journal of oncology, 37:583-593, 2010
• The combination of baicalin and baicalein enhances apoptosis via the ERK/p38 MAPK pathway in human breast cancer cells, (QM.Zhou), S.Wamg, H.Zhang, YY.Lu, XF.Wang, Y.Motoo, SB.Su, Acta pharmacologica Sinica, 30:1648-1658, Dec. 2009
• An emerging strategy for cancer treatment targeting aberrant glycogen synthase kinase 3beta., (K.Miyashita), M.Nakada, K.Shakoori, Y.Ishigaki, T.Shimasaki, Y.Motoo, Kawakami K, T.Minamoto, Anti-cancer agents in medicinal chemistry, 9:1114-1122, Dec. 2009
• Deregulated GSK3β Sustains Gastrointestinal Cancer Cells Survival by Modulating Human Telomerase Reverse Transcriptase and Telomerase, (W.Mai), K.Kawakami, A.Shakoori, S.Kyo, K.Miyashita, K.Yokoi, M.Jin, T.Shimasaki, Y.Motoo, T.Minamoto, Clinical cancer research : an official journal of the American Association for Cancer Research., 15：6810-6819, Nov. 2009
• Effect of kampo medicine on the long-termadministration of NSAIDs in three cases of gonarthrosis, J.Moriya, J.Yamakawa, Y.Motoo, 18：82-87, Jun. 2008
• A case undergoing repeated anaphylactic shok after systemic administration of vinorelbine, Y.Takahashi, T.Kiba, K.Yamaguchi, Y.Saitou, K.Nishio, M.Iguchi, Y.Motoo, 34:2321-2323, Dec. 2007
• A kampo medicine, boi-ogi-to, inhibits obesity in ovariectomized rats, J.Yamakawa, J.Moriya, T.Takahashi, A.Ishige, Y.Motoo, F.Yoshizaki, T.Kanda, eCAM, 42013, Nov. 2007
• Large defects of type l allergic response in telomerase reverse transcriptase knockout mice, (A.Ujike-Asai), A.Okada, Y.Du, M.Maruyama, X.Yuan, F.Ishikawa, Y.Motoo, K.Isobe, H.Nakajima, Journal of leukocyte biology, 82:429-435, Aug. 2007
• Expression of interleukin-22 in human melanoma cell line.(in Chinese), (J.Pei-hong), Y.Motoo, J. Clin. Dermatology., 36:346-347, Jun. 2007
• Apoptosis-related gene expression profile is changed by gemcitabine in pancreatic cancer cell line(PANC-1), T.Shimasaki, Y.Ishigaki, T.Minato, Y.Motoo, 22:14-20, Mar. 2007
• Pancreatitis-associated protein: from a lectin to an anti-inflammatory cytokine., (D.Closa), Y.Motoo, JL.Iovanna, World journal of gastroenterology : WJG., 13:170-174, Feb. 2007
• Tumor protein 53-induced nuclear protein 1 expression is repressed by miR-155, and its restoration inhibits pancreatic tumor development., (M.Gironella), M.Seux, M-J.Xie, C.Cano, R.Tomasini, J.Gommeaux, S.Garcia, J.Nowak, ML.Yeung, K-T.Jeang, A.Chaix, L.Fazli, Y.Motoo, Q.Wang, P.Rocchi, A.Russo, M.Gleave, J-C.Dagorn, JL.Iovanna, A.Carrier, M-J.Pebusque, NJ.Dusetti, Proceedings of the National Academy of Sciences of the United States of America, 104:16170-16175, 2007
• Suppressive effect of herbal medicine saikokeishito on acinar cell apoptosis in rat spontaneous chronic pancreatitis, (S-B.Su), M-J.Xie, N.Sawabu, Y.Motoo, Pancreatology : official journal of the International Association of Pancreatology (IAP) ... [et al.], 7:28-36, 2007
• High level of tumour protein p53-induced nuclear protein 1 (TP53INP1) expression in anaplastic carcinoma of the thyroid, (Y.Ito), Y.Motoo, H.Yoshida, JL.Iovanna, Y.Nakamura, K.Kuma, A.Miyauchi, Pathology, 38:545-547, Dec. 2006
• Decreased expression of tumor protein p53-induced nuclear protein 1 (TP53INP1) in breast carcinoma., (Ito Y), Motoo Y, Yoshida H, Iovanna JL, Takamura Y, Miya A, Kuma K, Miyauchi A, Anticancer research., 26(6B):4391-4395., Nov. 2006
• Effectiveness of goshajinkigan on the cold sensation and dysthesia in a case of nodular multiple angiitis, J.Yamakawa, J.Moriya, K.Kusaka, T.Itoh, Y.Motoo, T.Kanda, 57：651-654, Sep. 2006
• Effects of Chinese herbal medicines on spontaneous chronic pancreatitis in rats and the pathological relationships between formulas and syndromes., Journal of Chinese Integrative Medicine, 4: 358-362, Jul. 2006
• Effects of Chinese herbal medicines on spontaneous chronic pancreatitis in rats and the pathological relationships between formulas and syndromes., (Su SB), Li YQ, Shen HY, Motoo Y, Journal of Chinese Integrative Medicine, 4: 358-62, Jul. 2006
• Effects of Chinese herbal medicines on spontaneous chronic pancreatitis in rats and the pathological relationships between formulas and syndromes, (SB.Su), YQ.Li, HY.Shen, Y.Motoo, Zhong xi yi jie he xue bao = Journal of Chinese integrative medicine, 4:358-362, Jul. 2006
• Effect of gemcitabine on the expression of apoptosis-related genes in human pancreatic cancer cells, (J.Pei-Hong), Y.Motoo, N.Sawabu, T.Minamoto, World journal of gastroenterology : WJG., 12:1597-1602, Mar. 2006
• Down-expression of tumor protein p53-induced nuclear protein 1 in human gastric cancer, World J Gastroenterol, 12: 691-696, Feb. 2006
• Tumor protein p53-induced nuclear protein 1 (TP53INP1) in spontaneous chronic pancreatitis in the WBN/Kob rat: drug effects on its expression in the pancreas., (P-H.Jiang), Y.Motoo, JL.Iovanna, M-J.Pebusque, M-J.Xie, G.Okada, N.Sawabu, Journal of the Pancreas, 5:205-216, 2004
• Expression of vacuole membrane protein 1 (VMP1) in spontaneous chronic pancreatitis in the WBN/Kob rat., (P-H.Jiang), Y.Motoo, MI .Vaccaro, JL.Iovanna, G.Okada, N.Sawabu, Pancreas, 29:225-230, 2004
• Expression of interleukin-8 in human obstructive pancreatitis., Y.Motoo, M-J.Xie, H.Mouri, N.Sawabu, Journal of the Pancreas (Online), 5:138-144, 2004
• Overexpression of pancreatitis-associated protein (PAP) in human pancreatic ductal adenocarcinoma., (M-J.Xie), Y.Motoo, JL.Iovanna, SB.Su, K.Ohtsubo, F.Matsubara, N.Sawabu, DIGESTIVE DISEASES AND SCIENCES, 48:459-64, 2003
• Superoxide dismutase is induced during rat pancreatic acinar cell injury., (SB.Su), Y.Motoo, M-J.Xie, H.Mouri, K.Asayama, N.Sawabu, Pancreas, 24:146-152, 2002
• Effect of carboxamide derivative IS-741 on rat spontaneous chronic pancreatitis., (M-J.Xie), Y.Motoo, SB.Su, JL.Iovanna, N.Sawabu, DIGESTIVE DISEASES AND SCIENCES, 47:139-147, 2002
• Expression of p8 in human pancreatic cancer, (SB.Su), Y.Motoo, JL.Iovanna, M-J.Xie, H.Mouri, K.Ohtsubo, Y,Yamaguchi, H,Watanabe, T,Okai, F,Matsubara, N.Sawabu, Clin. Cancer Res., 7:309-313, Feb. 2001
• p8 expression is induced in acinar cells during chronic pancreatitis., Y.Motoo, JL.Iovanna, GV.Mallo, SB.Su, M-J.Xie, N.Sawabu, DIGESTIVE DISEASES AND SCIENCES, 46:1640-1646, 2001
• Usefulness of supernatant of pancreatic juice for genetic analysis of K-ras in diagnosis of pancreatic carcinoma., (A.Ha), H.Watanabe, Y.Yamaguchi, K.Ohtsubo, Y.Wang, Y.Motoo, T.Okai, T.Wakabayahi, N.Sawabu, PANCREAS, 23: 356？363, 2001
• Pneumatosis intestinalis and hepatic portal venous gas caused by mesenteric ischemia in an aged person., (K.Ohtsubo), T.Okai, Y.Yamaguchi, H.Watanabe, Y.Motoo, O.Matsui, N.Sawabu, JOURNAL OF GASTROENTEROLOGY, 36:338-340, 2001
• Pancreatitis-associated protein (PAP) levels in pancreatic juice from patients with pancreatic diseases., Y.Motoo, H.Watanabe, Y.Yamaguchi, M-J.Xie, N.Sawabu, PANCREATOLOGY, 1:43-47, 2001
• Hepatic peribiliary cysts diagnosed by magnetic resonance cholangiography., Y.Motoo, Y.Yamaguchi, H.Watanabe, T.Okai, JOURNAL OF GASTROENTEROLOGY, 36:271-275, 2001
• Expression of tumor necrosis factor-alpha, interleukin-6, and interferon-gamma in spontaneous chronic pancreatitis in the WBN/Kob rat., (M-J..Xie), Y.Motoo, SB.Su, N.Sawabu, PANCREAS, 22:400-408, 2001
• Expression of clusterin in pancreatic acinar cell injuries in vivo and in vitro., Y.Motoo, M-J.Xie, SB.Su, N.Sawabu, PANCREAS, 22:126-134, 2001
• Effect of herbal medicine Keishi-to (TJ-45) and its components on rat pancreatic acinar cell injuries in vivo and in vitro., Y.Motoo, SB.Su, M-J.Xie, H.Mouri, H.Taga, N.Sawabu, PANCREATOLOGY, 1:102-109, 2001
• Apoptosis in rat spontaneous chronic pancreatitis:role of the Fas and Fas ligand system., (SB.Su), Y.Motoo, M-J.Xie, N.Sawabu, DIGESTIVE DISEASES AND SCIENCES, 46:166-175, 2001
• Anti-fibrotic effect of herbal medicine Saiko-keishi-to (TJ-10) on chronic pancreatitis in the WBN/Kob rat., (SB.Su), Y.Motoo, M-J.Xie, H.Taga, N.Sawabu, PANCREAS, 22:8-17, 2001
• Expression of transforming growth factor beta in spontaneous chronic pancreatitis in the WBN/Kob rat., (SB.Su), Y.Motoo, M-J.Xie, KMiyazono, N.Sawabu, DIGESTIVE DISEASES AND SCIENCES, 45:151-159, 2000
• Effect of herbal medicine Saiko-keishi-to (TJ-10) on rat spontaneous chronic pancreatitis: comparison with other herbal medicines, Y.Motoo, SB.Su, M-JXie, H.Taga, N.Sawabu, INTERNATIONAL JOURNAL OF PANCREATOLOGY, 27:123-129, 2000
• Does the depth of gastric ulceration influence a modified dual therapy with amoxicillin and lansoprazole for Helicobacter pylori-associated gastric ulcer?, (T.Okai), K.Ohtsubo, J.Sakai, Y.Motoo, H.Watanabe, A.Kawashima, N.Sawabu, Canadian Journal of Gasroenterology, 14:761-766, 2000
• Arginine induces apoptosis and gene expression of pancreatitis-associated protein (PAP) in pancreatic acinar AR4-2J cells., Y.Motoo, K.Taga, SB.Su, M-J.Xie, N.Sawabu, PANCREAS, 20:61-66, 2000
• Urinary gonadotropin peptide as acute phase reactant: transient elevation after operation for digestive diseases., Y.Motoo, H.Watanabe, T.Okai, N.Sawabu, EUROPEAN JOURNAL OF ENDOCRINOLOGY, 140:555-560, 1999
• Serum levels of pancreatitis-associated protein in digestive diseases with special reference to gastrointestinal cancers., Y.Motoo, Y.Satomura, I.Mouri, H.Mouri, K.Ohtsubo, J.Sakai, T.Fujii, H.Taga, Y.Yamaguchi, H.Watanabe, T,.Okai, N.Sawabu, Digestive Diseases and Sciences, 44:1142-1147, 1999
• Pancreatic cancer associated with granulocyte-colony stimulating factor production confirmed by immunohistochemistry., (K.Ohtsubo), H.Mouri, M.Akasofu, Y.Yamaguchi, H.Watanabe, T.Gabata, Y.Motoo, T.Okai, N.Sawabu, J.Sakai, JOURNAL OF CLINICAL GASTROENTEROLOGY, 27:357-60, 1999
• Mucin-producing biliary papillomatosis associated with gastrobiliary fistula., (K.Harada), Y.Nakanuma, H.Watanabe, Y.Motoo, T.Okai, N.Sawabu, JOURNAL OF GASTROENTEROLOGY, 34:141-4, 1999
• K-ras mutations in duodenal aspirate without secretin stimulation for screening of pancreatic and biliary tract carcinoma., (H.Watanabe), A.Ha, YX.Hu, K.Ohtsubo, Y.Yamaguchi, Y.Motoo, T.Okai, D.Toya, N.Tanaka, N.Sawabu, CANCER, 15:1441-1448, 1999
• Expression of pancreatitis-associated protein (PAP) in rat spontaneous chronic pancreatitis: effect of herbal medicine Saiko-keishi-to (TJ-10)., (SB.Su), Y.Motoo, M-J.Xie, J.Sakai, H.Taga, N.Sawabu, PANCREAS, 19:239-247, 1999
• Effect of Koso-san on globus pharyngeus., Y.Motoo, H.Taga, SB.Su, N.Sawabu, AMERICAN JOURNAL OF CHINESE MEDICINE, 27:283-288, 1999
• EUS and K-ras analysis of pure pancreatic juice collected via a duodenoscope after secretion stimulation for diagnosis of pancreatic mass lesion: a prospective study., (T.Okai), H.Watanabe, Y.Yamaguchi, I.Mouri, Y.Motoo, N.Sawabu, GASTROINTESTINAL ENDOSCOPY, 50:797-803, 1999
• Bcl-2 expression related to altered p53 protein and its impact on the progression of human pancreatic carcinoma., (YX.Hu), H.Watanabe, K.Ohtsubo, Y.Yamaguchi, A.Ha, Y.Motoo, T.Okai, N.Sawabu, Br J Cancer, 80:1075-1079, 1999
• Quantitative determination of K-ras mutations in pancreatic juice for diagnosis of pancreatic cancer using hybridization protection assay., (H.Watanabe), Y.Yamaguchi, A.Ha, YX.Hu, Y.Motoo, T.Okai, T.Yoshimura, N.Sawabu, PANCREAS, 17:341-347, 1998
• Infrequent expression of p21 is related to altered p53 protein in pancreatic carcinoma., (YX.Hu), H.Watanabe, K.Ohtsubo, Y.Yamaguchi, A.Ha, Y.Motoo, T.Okai, N.Sawabu, CLINICAL CANCER RESEARCH, 4:1147-1152, 1998
• Expression of pancreatitis-associated protein (PAP) mRNA in gastrointestinal cancers, Y.Motoo, T.Itoh, SB.Su, MT.Nakatani, H.Watanabe, T.Okai, N.Sawabu, INTERNATIONAL JOURNAL OF PANCREATOLOGY, 23:11-16, 1998
• Expression of multidrug resistance gene (mdr-1) mRNA in gastric and colorectal cancers., Y.Motoo, SB.Su, MT.Nakatani, N.Sawabu, ANTICANCER RESEARCH, 18:1903-1906, 1998
• Chronic pancreatitis with diffuse irregular narrowing of the main pancreatic duct., (T.Wakabayashi), Y.Motoo, Y.Kojima, H.Makino, N.Sawabu, DIGESTIVE DISEASES AND SCIENCES, 43:2415-2425, 1998
• Undifferentiated (anaplastic) carcinoma of the pancreas showing sarcomatous change and neoplastic cyst formation., Y.Motoo, A.Kawashima, H.Watanabe, SB.Su, T.Okai, Sawabu N, INTERNATIONAL JOURNAL OF PANCREATOLOGY, 21:243-248, 1997
• Sclerosing pancreatitis showing rapidly progressive changes with recurrent mass formation., Y.Motoo, T.Minamoto, H.Watanabe, J.Sakai, T.Okai, N.Sawabu, INTERNATIONAL JOURNAL OF PANCREATOLOGY, 21:85-90, 1997
• Prolonged intrahepatic cholestatsis in acute-onset, severe autoimmune hepatitis., Y.Motoo, N.Sawabu, H.Watanabe, T.Okai, Y.Nakanuma, JOURNAL OF GASTROENTEROLOGY, 32:410-413, 1997
• Effect of niuche-shen-qi-wan on painful muscle cramps in patients with liver cirrhosis: a preliminary report., Y.Motoo, H.Taga, Y.Yamaguchi, H.Watanabe, T.Okai, N.Sawabu, AMERICAN JOURNAL OF CHINESE MEDICINE, 25:97-102, 1997
• Effect of gegen-tang on painful gynecomastia in patients with liver cirrhosis: a brief report., Y.Motoo, H.Taga, SB.Su, N.Sawabu, AMERICAN JOURNAL OF CHINESE MEDICINE, 26:114, 1997
• Biliary papillomatosis with the point mutation of K-ras gene arising in congenital choledochal cyst, (H,Ohta), Y.Yamaguchi, O.Yamakawa, H.Watanabe, Y.Satomura, Y.Motoo, T.Okai, T.Terada, N.Sawabu, Gastroenterology, 105:1209-1212, 1993
• Malignant transformation of adenomatous hyperplasia to hepatocellular carcinoma, (T.Takayama), M.Makuuchi, S.Hirohashi, M.Sakamoto, N.Okazaki, K.Takayasu, T.Kosuge, Y.Motoo, S.Yamazaki, H.Hasegawa, Lancet, 336:1150-1153, 1990
• An exploratory study of social problems experienced by ambulatory cancer patients in Japan: Frequency and association with perceived need for help., Psychooncology, 27:1704-1710, Jul. 2018
• Clinical practice guidelines for the management of olfactory dysfunction - Secondary publication, Miwa T, Ikeda K, Ishibashi T, Kobayashi M, Kondo K, Matsuwaki Y, Ogawa T, Shiga H, Suzuki M, Tsuzuki K, Furuta A, Motoo Y, Fujieda S, Kurono Y, Auris Nasus Larynx, 46:653-662, Oct. 2019
• Perspectives on the use of ninjin'yoeito in modern medicine: a review of randomized controlled trials, (Takayama S), Arita R, Ohsawa M, Kikuchi A, Yasui H, Makino T, Motoo Y, Ishii T, Evidence-Based Complementary and Alternative Medicine, 2019:9590260, Sep. 2019
• The utilization of complementary and alternative medicine in Taiwan: An internet survey using an adapted version of the international questionnaire (I-CAM-Q), ( Huang CW), Tran DNH, Li TF, Sasaki Y, Lee JA, Lee MS, Arai I, Motoo Y, Yukawa K, Tsutani K, Ko SG, Hwang SJ, Chen FP, Journal of the Chinese Medical Association, 82:656-671, Aug. 2019
• Efficacy of daikenchuto, a traditional Japanese Kampo medicine, for postoperative intestinal dysfunction in patients with gastrointestinal cancers: meta-analysis, (Hosaka M), Arai I, Ishiura Y, Ito T, Seki Y, Naito T, Matsuzawa Y, Nakayama T, Motoo Y, International Journal of Clinical Oncology, 24:1385-1396, Jul. 2019
• Complementary and Alternative Medicine for Breast Cancer Patients:An Overview of Systematic Reviews, Yui Sasaki, Chunhoo Cheon, Yoshiharu Motoo, Soobin Jang, Sunju Park, Seong-Gyu Ko, Bo-Hyoung Jang, Deok-Sang Hwang, YAKUGAKU ZASSHI, 139:1027-1046, Jul. 2019
• Nivolumab-related sclerosing cholangitis in gastric cancer, Motoo Y, Internal Medicine, 58:1197, May 2019
• Internet survey on the provision of complementary and alternative medicine in Japanese private clinics: a cross-sectional study, Motoo Y, Yukawa K, Hisamura K, Tsutani K, Arai I, Journal of integrative medicine, 17:8-13, Jan. 2019
• Use of complementary and alternative medicine in Japan: a cross-sectional internet survey using the Japanese version of the International Complementary and Alternative Medicine Questionnaire, Motoo Y, Yukawa K, Arai I, Hisamura K, Tsutani K, JMA Journal, 2:35-46, 2019
• Estimated incidence per population of adverse drug reactions to Kampo medicines from the Japanese Adverse Drug Event Report Database (JADER) : a prelude to the risk management plan, (Arai I), Harada Y, Koda H, Tsutani K, Motoo Y, Traditional & Kampo Medicine, 7:3-16, Apr. 2020
• Prophylactic efficacy of ninjin’yoeito for oxaliplatin-induced cumulative peripheral neuropathy in patients with colorectal cancer receiving postoperative adjuvant chemotherapy: a randomized, open-label, phase 2 trial (HOPE-2), Motoo Y, Tomita Y, Fujita H, International Journal of Clinical Oncology, 25:1123-1129, Mar. 2020
• Acupuncture improved lipid metabolism by regulating intestinal absorption in mice, Jia Han, Xin Guo, Xiang-Jin Meng, Jing Zhang, Reimon Yamaguchi, Yoshiharu Motoo, Sohsuke Yamada, World Journal of Gastroenterology, 26:5118-5129, Sep. 2020