Japanese

OKUWA Takako

■Faculty	Department of Microbiology
■Position	Assistant Professor

Researcher Profile & Settings

Research

Overview of research:

Molecular biology of Saffold virus

Academic & Professional Experience

Feb. 2009Kanazawa Medical University School of Medicine Assistant professor

Research Activities

Research Areas

Medicine,dentistry, and pharmacy / Basic medicine
Medical, Dental, and Pharmaceutical Science
Research Project: Virology

Published Papers

A mouse monoclonal antibody against influenza C virus attenuates acetaminophen-induced liver injury in mice., (Sasaki Yutaka);Yoshino Naoto;Okuwa Takako;Odagiri Takashi;Satoh Takashi;Muraki Yasushi, Scientific reports, 11:11816, 2021
DOI:10.1038/s41598-021-91251-x
The epitope sequence of S16, a monoclonal antibody against influenza C virus hemagglutinin-esterase fusion glycoprotein, Okuwa, Takako;Sasaki, Yutaka;Matsuzaki, Yoko;Himeda, Toshiki;Yoshino, Naoto;Hongo, Seiji;Ohara, Yoshiro;Muraki, Yasushi, FUTURE VIROLOGY, 12:93-101, Mar. 2017
DOI:10.2217/fvl-2016-0105
Saffold Cardiovirus Infection in a 2-Year-Old Boy with Acute Pancreatitis, (Ito, Hisato);Miyagaki, Satoshi;Sakaue, Satoshi;Matsui, Fumihiro;Katsumi, Yoshiki;Otabe, Osamu;Torii, Jun;Itagaki, Tsutomu;Himeda, Toshiki;Okuwa, Takako;Ohara, Yoshiro, JAPANESE JOURNAL OF INFECTIOUS DISEASES, 70:105-107, Jan. 2017
DOI:10.7883/yoken.JJID.2015.488
Role(s) of leader protein of saffold virus., (A.Shimizu), T.Himeda, T.Okuwa, Y.Muraki, Y.Ohara, Clinical & experimental neuroimmunology [electronic resource], 5:362-366, 2014
Saffold virus type 3 (SAFV-3) persists in HeLa cells., T.Himeda, T.Hosomi, T.Okuwa, Y.Muraki, Y.Ohara, PloS one, 8:e53194;1-8, 2013
Possibility of neuropathogenesis of Saffold virus suggested from the in vitro virus persistence., T.Himeda, T.Okuwa, Y.Muraki, Y.Ohara, Clinical & experimental neuroimmunology [electronic resource], 4:163-164, 2013
Effect of cysteine mutations in the extracellular domain of CM2 on the Influenza C virus replication., Y.Muraki, T.Okuwa, T.Himeda, S.Hongo, Y.Ohara, PloS one, 8:e60510;1-10, 2013
Glycosylation of CM2 is important for efficient replication of influenza C virus, T.Okuwa, Y.Muraki, T.Himeda, Y.Ohara, Virology., 433:167-175, 2012
Reverse genetic analysis of the recombination in theilovirus based on the infectious cDNA clones, T.Himeda, M.Nojiri, T.Okuwa, Y.Muraki, Y.Ohara, Journal of Plant Pathology & Microbiology, 0.086111111, Dec. 2011
The Preparation of an infectious full-length cDNA clone of saffold virus, T.Himeda, T.Hosomi, N.Asif, H.Shimizu, T.Okuwa, Y.Muraki, Y.Ohara, Virology journal [electronic resource], 0.409722222, Feb. 2011
Palmitoylation of CM2 is dispensable to influenza C virus replication, Y.Muraki, T.Okuwa, T.Furukawa, Y.Matsuzaki, K.Sugawara, T.Himeda, S.Hongo, Y.Ohara, Virus research., 157:99-105, Feb. 2011
The role of nonstructural proteins of Theiler's murine encephalomyelitis virus, L and L*, in virus demyelination, Y.Ohara, T.Okuwa, T.Himeda, 200-202, Sep. 2010
Activation of the PI3K-Akt pathway by human T cell leukemia virus type 1 (HTLV-1) oncoprotein Tax increases Bcl3 expression, which is associated with enhanced growth of HTLV-1-infected T cells, K.Saito, M.Saito, N.Taniura, T.Okuwa, Y.Ohara, Virology., 403:173-180, Aug. 2010
Opposite effects of two nonstructural proteins of Theiler’s murine encephalomyelitis virus regulates apoptotic cell death in BHK-21 cells, T.Okuwa, N.Taniura, M.Saito, T.Himeda, Y.Ohara, Microbiology and immunology., 54:639-643, Jul. 2010
Cytokine/chemokine profile in J774 macrophage cells persistently infected with DA strain of Theiler's murine encephalomyelitis virus (TMEV), T.Himeda, T.Okuwa, Y.Muraki, Y.Ohara, Journal of neurovirology., 16: 219-229, Jun. 2010
Leader(L) of Theiler's murine encephalomyelitis virus (TMEV) is required for virus growth in a murine macrophage-like cell line, K.Ichinose-Asakura, N.Taniura, T.Himeda, M.Nojiri, T.Okuwa, Y.Ohara, Virus research., 147:224-230, Feb. 2010
The anti-apoptotic protein L* of Theiler’s murine encephalomyelitis virus (TMEV) contains a mitochondrial targeting signal, T.Himeda, T.Okuwa, M.Nojiri, Y.Muraki, Y.Ohara, Virus research., 155:381-388, 2010
Different subcellular localization of Theiler's murine encephalomyelitis virus leader proteins of GDVII and DA strains in BHK-21 cells, N.Taniura, M.Saito, T.Okuwa, K.Saito, Y.Ohara, Journal of virology., 83: 6624-6630, Jul. 2009
Theiler's murine encephalomyelitis virus leader protein amino acid residue 57 regulates subgroup-specific virus growth on BHK-21 cells, M.Takano-Maruyama, Y.Ohara, K.Asakura, T.Okuwa, Journal of virology., 80: 12025-12031, Dec. 2006
Leader (L) and L* proteins of Theiler's murine encephalomyelitis virus (TMEV) and their regulation of the virus' biological activities, M.Takano-Maruyama, Y.Ohara, K.Asakura, T.Okuwa, Journal of neuroinflammation, 3:19-26, Aug. 2006
Generation of a mutant of Theiler's murine encephalomyelitis virus (TMEV) causing demyelination in the brain of susceptible mice, T.Okuwa, M.Takano-Maruyama, K.Asakura, M.Murayama, Y.Ohara, 8th International Congres of Neuroimmunology Free Papers, 253-255, 2006
Leader (L) and L* proteins of Theiler's murine encephalomyelitis virus (TMEV) and their regulation of the virus' biological activities., Takano-Maruyama Masumi;Ohara Yoshiro;Asakura Kunihiko;Okuwa Takako, Journal of neuroinflammation, 3, 2006
Generation of a recombinant Saffold Virus expressing UnaG as a marker for the visualization of viral infection., Takako Okuwa, Tosiki Himeda, koichi Utani, Masaya Higuchi, 20:175, Aug. 2023
DOI:10.1186/s12985-023-02142-8
Theilovirus 3C Protease Cleaves the C-Terminal Domain of the Innate Immune RNA Sensor, Melanoma Differentiation-Associated Gene 5, and Impairs Double-Stranded RNA-Mediated IFN Response, (Masahiko Miyamoto), Toshiki Himeda, Kazuki Ishihara, Takako Okuwa, Daiki Kobayashi, Masaaki Nameta, Yu Karasawa, Benyapa Chunhaphinyokul, Yutaka Yoshida, Nobuyuki Tanaka, Masaya Higuchi, Akihiko Komuro, The Journal of Immunology, 210:335, Feb. 2023
DOI:10.4049/jimmunol.2200565
Theiler's murine encephalomyelitis virus leader protein amino acid residue 57 regulates subgroup-specific virus growth on BHK-21 cells., Takano-Maruyama Masumi;Ohara Yoshiro;Asakura Kunihiko;Okuwa Takako, Journal of virology, 80, 2006
Different subcellular localization of Theiler's murine encephalomyelitis virus leader proteins of GDVII and DA strains in BHK-21 cells., Taniura Naoko;Saito Mineki;Okuwa Takako;Saito Kousuke;Ohara Yoshiro, Journal of virology, 83, 2009
DOI:10.1128/JVI.02385-08
Leader (L) of Theiler's murine encephalomyelitis virus (TMEV) is required for virus growth in a murine macrophage-like cell line., Ichinose-Asakura Keiko;Taniura Naoko;Himeda Toshiki;Himeda Naoko Taniura Toshiki;Nojiri Masafumi;Okuwa Takako;Ohara Yoshiro, Virus research, 147, 2010
DOI:10.1016/j.virusres.2009.11.004
Activation of the PI3K-Akt pathway by human T cell leukemia virus type 1 (HTLV-1) oncoprotein Tax increases Bcl3 expression, which is associated with enhanced growth of HTLV-1-infected T cells., Saito Kousuke;Saito Mineki;Taniura Naoko;Okuwa Takako;Ohara Yoshiro, Virology, 403, 2010
DOI:10.1016/j.virol.2010.04.018
Cytokine/chemokine profile in J774 macrophage cells persistently infected with DA strain of Theiler's murine encephalomyelitis virus (TMEV)., Himeda Toshiki;Okuwa Takako;Muraki Yasushi;Ohara Yoshiro, Journal of neurovirology, 16, 2010
DOI:10.3109/13550284.2010.484040
The anti-apoptotic protein L(*) of Theiler's murine encephalomyelitis virus (TMEV) contains a mitochondrial targeting signal., Himeda Toshiki;Okuwa Takako;Nojiri Masafumi;Muraki Yasushi;Ohara Yoshiro, Virus research, 155, 2011
DOI:10.1016/j.virusres.2010.11.006
Opposite effects of two nonstructural proteins of Theiler’s murine encephalomyelitis virus regulates apoptotic cell death in BHK-21 cells., Okuwa Takako;Taniura Naoko;Saito Mineki;Himeda Toshiki;Ohara Yoshiro, Microbiology and immunology, 54, 2010
DOI:10.1111/j.1348-0421.2010.00260.x
Palmitoylation of CM2 is dispensable to influenza C virus replication., Muraki Yasushi;Okuwa Takako;Furukawa Takatoshi;Matsuzaki Yoko;Sugawara Kanetsu;Himeda Toshiki;Hongo Seiji;Ohara Yoshiro, Virus research, 157, 2011
DOI:10.1016/j.virusres.2011.02.013
The preparation of an infectious full-length cDNA clone of Saffold virus., Himeda Toshiki;Hosomi Takushi;Asif Naeem;Shimizu Hiroyuki;Okuwa Takako;Muraki Yasushi;Ohara Yoshiro, Virology journal, 8, 2011
DOI:10.1186/1743-422X-8-110
Glycosylation of CM2 is important for efficient replication of influenza C virus., Okuwa Takako;Muraki Yasushi;Himeda Toshiki;Ohara Yoshiro, Virology, 433, 2012
DOI:10.1016/j.virol.2012.08.010
Saffold virus type 3 (SAFV-3) persists in HeLa cells., Himeda Toshiki;Hosomi Takushi;Okuwa Takako;Muraki Yasushi;Ohara Yoshiro, PloS one, 8, 2013
DOI:10.1371/journal.pone.0053194
Effect of cysteine mutations in the extracellular domain of CM2 on the influenza C virus replication., Muraki Yasushi;Okuwa Takako;Himeda Toshiki;Hongo Seiji;Ohara Yoshiro, PloS one, 8, 2013
DOI:10.1371/journal.pone.0060510
A mouse monoclonal antibody against influenza C virus attenuates acetaminophen-induced liver injury in mice., Sasaki Yutaka;Yoshino Naoto;Okuwa Takako;Odagiri Takashi;Satoh Takashi;Muraki Yasushi, Scientific reports, 11, 2021
DOI:10.1038/s41598-021-91251-x

Note: Performance information for the past 1-2 years may be revised at a later date due to inspections conducted by the committee from July to September every year.