OKUWA Takako

FacultyDepartment of Microbiology
PositionAssistant Professor

Researcher Profile & Settings


    Overview of research:
    Molecular biology of influenza virus

Academic & Professional Experience

  • Feb. 2009Kanazawa Medical University School of Medicine Assistant professor

Research Activities

Published Papers

  • Role(s) of leader protein of saffold virus., (A.Shimizu), T.Himeda, T.Okuwa, Y.Muraki, Y.Ohara, Clinical & experimental neuroimmunology [electronic resource]5:362-3662014
  • Saffold virus type 3 (SAFV-3) persists in HeLa cells., T.Himeda, T.Hosomi, T.Okuwa, Y.Muraki, Y.Ohara, PloS one8:e53194;1-82013
  • Possibility of neuropathogenesis of Saffold virus suggested from the in vitro virus persistence., T.Himeda, T.Okuwa, Y.Muraki, Y.Ohara, Clinical & experimental neuroimmunology [electronic resource]4:163-1642013
  • Effect of cysteine mutations in the extracellular domain of CM2 on the Influenza C virus replication., Y.Muraki, T.Okuwa, T.Himeda, S.Hongo, Y.Ohara, PloS one8:e60510;1-102013
  • Reverse genetic analysis of the recombination in theilovirus based on the infectious cDNA clones, T.Himeda, M.Nojiri, T.Okuwa, Y.Muraki, Y.Ohara, Journal of Plant Pathology & Microbiology0.086111111Dec. 2011
  • The Preparation of an infectious full-length cDNA clone of saffold virus, T.Himeda, T.Hosomi, N.Asif, H.Shimizu, T.Okuwa, Y.Muraki, Y.Ohara, Virology journal [electronic resource]0.409722222Feb. 2011
  • Palmitoylation of CM2 is dispensable to influenza C virus replication, Y.Muraki, T.Okuwa, T.Furukawa, Y.Matsuzaki, K.Sugawara, T.Himeda, S.Hongo, Y.Ohara, Virus research.157:99-105Feb. 2011
  • The role of nonstructural proteins of Theiler's murine encephalomyelitis virus, L and L*, in virus demyelination, Y.Ohara, T.Okuwa, T.Himeda200-202Sep. 2010
  • Activation of the PI3K-Akt pathway by human T cell leukemia virus type 1 (HTLV-1) oncoprotein Tax increases Bcl3 expression, which is associated with enhanced growth of HTLV-1-infected T cells, K.Saito, M.Saito, N.Taniura, T.Okuwa, Y.Ohara, Virology.403:173-180Aug. 2010
  • Cytokine/chemokine profile in J774 macrophage cells persistently infected with DA strain of Theiler's murine encephalomyelitis virus (TMEV), T.Himeda, T.Okuwa, Y.Muraki, Y.Ohara, Journal of neurovirology.16: 219-229Jun. 2010
  • Leader(L) of Theiler's murine encephalomyelitis virus (TMEV) is required for virus growth in a murine macrophage-like cell line, K.Ichinose-Asakura, N.Taniura, T.Himeda, M.Nojiri, T.Okuwa, Y.Ohara, Virus research.147:224-230Feb. 2010
  • The anti-apoptotic protein L* of Theiler’s murine encephalomyelitis virus (TMEV) contains a mitochondrial targeting signal, T.Himeda, T.Okuwa, M.Nojiri, Y.Muraki, Y.Ohara, Virus research.155:381-3882010
  • Different subcellular localization of Theiler's murine encephalomyelitis virus leader proteins of GDVII and DA strains in BHK-21 cells, N.Taniura, M.Saito, T.Okuwa, K.Saito, Y.Ohara, Journal of virology.83: 6624-6630Jul. 2009
  • Theiler's murine encephalomyelitis virus leader protein amino acid residue 57 regulates subgroup-specific virus growth on BHK-21 cells, M.Takano-Maruyama, Y.Ohara, K.Asakura, T.Okuwa, Journal of virology.80: 12025-12031Dec. 2006
  • Leader (L) and L* proteins of Theiler's murine encephalomyelitis virus (TMEV) and their regulation of the virus' biological activities, M.Takano-Maruyama, Y.Ohara, K.Asakura, T.Okuwa, Journal of neuroinflammation3:19-26Aug. 2006
  • Generation of a mutant of Theiler's murine encephalomyelitis virus (TMEV) causing demyelination in the brain of susceptible mice, T.Okuwa, M.Takano-Maruyama, K.Asakura, M.Murayama, Y.Ohara, 8th International Congres of Neuroimmunology Free Papers253-2552006
  • The epitope sequence of S16, a monoclonal antibody against influenza C virus hemagglutinin-esterase fusion glycoprotein, Okuwa, Takako;Sasaki, Yutaka;Matsuzaki, Yoko;Himeda, Toshiki;Yoshino, Naoto;Hongo, Seiji;Ohara, Yoshiro;Muraki, Yasushi, FUTURE VIROLOGY12:93-101Mar. 2017
  • Saffold Cardiovirus Infection in a 2-Year-Old Boy with Acute Pancreatitis, (Ito, Hisato);Miyagaki, Satoshi;Sakaue, Satoshi;Matsui, Fumihiro;Katsumi, Yoshiki;Otabe, Osamu;Torii, Jun;Itagaki, Tsutomu;Himeda, Toshiki;Okuwa, Takako;Ohara, Yoshiro, JAPANESE JOURNAL OF INFECTIOUS DISEASES70:105-107Jan. 2017

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