AKAI Ryoko

FacultyDepartment of Life Sciences, Medical Research Institute
PositionAssistant

Researcher Profile & Settings

Research

    Overview of research:
    Physiological and pathological function of cellular stress response

Special Field

  • Basic medicine
  • Cell biology
  • Laboratory animal science

Research Activities

Published Papers

  • Inhibition of skin fibrosis in systemic sclerosis by botulinum toxin B via the suppression of oxidative stress, (Baral H), Sekiguchi A, Uchiyama A, Nisaa Amalia S, Yamazaki S, Inoue Y, Yokoyama Y, Ogino S, Torii R, Hosoi M, Akai R, Iwawaki T, Ishikawa O, Motegi SI, J Dermatol48:1052-1061Jul. 2021
  • Spatiotemporal analysis of the UPR transition induced by methylmercury in the mouse brain, (Hiraoka H), Nomura R, Takasugi N, Akai R, Iwawaki T, Kumagai Y, Fujimura M, Uehara T, Arch Toxicol95:1241-1250Apr. 2021
  • Protective effect of dimethyl fumarate for the development of pressure ulcers after cutaneous ischemia-reperfusion injury, Inoue Y, Uchiyama A, Sekiguchi A, Yamazaki S, Fujiwara C, Yokoyama Y, Ogino S, Torii R, Hosoi M, Akai R, Iwawaki T, Ishikawa O, Motegi SI, Wound Repair Regen28:600-6082020
  • Transgenic mouse model exhibiting weak red fluorescence before and strong green fluorescenceafter Cre/loxP-mediated recombination, Akai R, Saito M, Kohno K, Iwawaki T, Exp Anim69:306-3182020
  • Apelin/APJ signaling suppresses the pressure ulcer formation in cutaneous ischemia-reperfusion injury mouse model, Yamazaki S, Sekiguchi A, Uchiyama A, Fujiwara C, Inoue Y, Yokoyama Y, Ogino S, Torii R, Hosoi M, Akai R, Iwawaki T, Ishikawa O, Motegi SI, Sci Rep10:13492020
  • Inhibitory effect of kaempferol on skin fibrosis in systemic sclerosis by the suppression of oxidative stress, Sekiguchi A, Motegi SI, Fujiwara C, Yamazaki S, Inoue Y, Uchiyama A, Akai R, Iwawaki T, Ishikawa O, J Dermatol Sci96:8-172019
  • Zinc deficiency exacerbates pressure ulcers by increasing oxidative stress and ATP in the skin, (Nakamura H), Sekiguchi A, Ogawa Y, Kawamura T, Akai R, Iwawaki T, Makiguchi T, Yokoo S, Ishikawa O, Motegi SI, J Dermatol Sci95:62-692019
  • IRE1α governs cytoskeleton remodelling and cell migration through a direct interaction with filamin A, Urra H, Henriquez DR, Cánovas J, Villarroel-Campos D, Carreras-Sureda A, Pulgar E, Molina E, Hazari YM, Limia CM, Alvarez-Rojas S, Figueroa R, Vidal RL, Rodriguez DA, Rivera CA, Court FA, Couve A, Qi L, Chevet E, Akai R, Iwawaki T, Concha ML, Glavic Á, Gonzalez-Billault C, Hetz C, Nat Cell Biol20:942-9532018
  • Botulinum toxin B suppresses the pressure ulcer formation in cutaneous ischemia-reperfusion injury mouse model: Possible regulation of oxidative and endoplasmic reticulum stress, Sekiguchi A, Motegi SI, Uchiyama A, Uehara A, Fujiwara C, Yamazaki S, Perera B, Nakamura H, Ogino S, Yokoyama Y, Akai R, Iwawaki T, Ishikawa O, J Dermatol Sci90:144-1532018
  • Transgenic mouse model for imaging of ATF4 translational activation-related cellular stress responses in vivo, Iwawaki T, Akai R, Toyoshima T, Takeda N, Ishikawa T, Yamamura K, Sci Rep7:462302017
  • Protective effect of mesenchymal stem cells on the pressure ulcer formation by the regulation of oxidative and endoplasmic reticulum stress, Motegi SI, Sekiguchi A, Uchiyama A, Uehara A, Fujiwara C, Yamazaki S, Perera B, Nakamura H, Ogino S, Yokoyama Y, Akai R, Iwawaki T, Ishikawa O, Sci Rep7:171862017
  • Constitutive role of GADD34 and CReP in cancellation of phospho-eIF2α-dependent translational attenuation and insulin biosynthesis in pancreatic β cells, Akai R, Hosoda A, Yoshino M, Iwawaki T, Genes Cells20:871-8862015
  • Transgenic mouse model for imaging of interleukin-1β-related inflammation in vivo, Iwawaki T, Akai R, Oikawa D, Toyoshima T, Yoshino M, Suzuki M, Takeda N, Ishikawa TO, Kataoka Y, Yamamura K, Sci Rep5:172052015
  • Evaluating experimental cerebral malaria using oxidative stress indicator OKD48 mice, Imai T, Iwawaki T, Akai R, Suzue K, Hirai M, Taniguchi T, Okada H, Hisaeda H, Int J Parasitol44:681-6852014
  • A transgenic mouse model for monitoring oxidative stress, Oikawa D, Akai R, Tokuda M, Iwawaki T, Sci Rep2:2292012
  • Positive contribution of Erdj5/JPDI to endoplasmic reticulum protein quality control in the salivary gland, Hosoda A, Tokuda M, Akai R, Kohno K, Iwawaki T, Biochem J425:117-1252010
  • Positive contribution of the IRE1α-XBP1 pathway to placental expression of CEA family genes, Oikawa D, Akai R, Iwawaki T, FEBS Lett584:1066-10702010
  • IRE1α disruption causes histological abnormality of exocrine tissues, increase of blood glucose level, and decrease of serum immunoglobulin level, Iwawaki T, Akai R, Kohno K, PLoS ONE5:e130522010
  • Function of IRE1 alpha in the placenta is essential for placental development and embryonic viability, Iwawaki T, Akai R, Yamanaka S, Kohno K, Proc Natl Acad Sci USA106:16657-166622009
  • Analysis of the XBP1 splicing mechanism using endoplasmic reticulum stress-indicators, Iwawaki T, Akai R, Biochem Biophys Res Commun350:709-7152006
  • A transgenic mouse model for monitoring endoplasmic reticulum stress, Iwawaki T, Akai R, Kohno K, Miura M, Nat Med10:98-1022004


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