AKAI Ryoko

Researcher Profile & Settings

Research

Overview of research:
Physiological and pathological function of cellular stress response

Special Field

• Basic medicine
• Cell biology
• Laboratory animal science

Research Activities

Published Papers

• Dynamic change and preventive role of stress response via Keap1-Nrf2 during renal crystal formation, Ushimoto C, Sugiki S, Kunii K, Inoue S, Kuroda E, Akai R, Iwawaki T, Miyazawa K., 207:120-132, Oct. 2023
• Inhibition of skin fibrosis in systemic sclerosis by botulinum toxin B via the suppression of oxidative stress, Baral H, Sekiguchi A, Uchiyama A, Nisaa Amalia S, Yamazaki S, Inoue Y, Yokoyama Y, Ogino S, Torii R, Hosoi M, Akai R, Iwawaki T, Ishikawa O, Motegi SI, J Dermatol, 48:1052-1061, 2021
  DOI:10.1111/1346-8138.15888
• Spatiotemporal analysis of the UPR transition induced by methylmercury in the mouse brain, Hiraoka H, Nomura R, Takasugi N, Akai R, Iwawaki T, Kumagai Y, Fujimura M, Uehara T, Arch Toxicol, 95:1241-1250, 2021
  DOI:10.1007/s00204-021-02982-9
• Protective effect of dimethyl fumarate for the development of pressure ulcers after cutaneous ischemia-reperfusion injury, Inoue Y, Uchiyama A, Sekiguchi A, Yamazaki S, Fujiwara C, Yokoyama Y, Ogino S, Torii R, Hosoi M, Akai R, Iwawaki T, Ishikawa O, Motegi SI, Wound Repair Regen, 28:600-608, 2020
  DOI:10.1111/wrr.12824
• Transgenic mouse model exhibiting weak red fluorescence before and strong green fluorescenceafter Cre/loxP-mediated recombination, Akai R, Saito M, Kohno K, Iwawaki T, Exp Anim, 69:306-318, 2020
  DOI:10.1538/expanim.19-0085
• Apelin/APJ signaling suppresses the pressure ulcer formation in cutaneous ischemia-reperfusion injury mouse model, Yamazaki S, Sekiguchi A, Uchiyama A, Fujiwara C, Inoue Y, Yokoyama Y, Ogino S, Torii R, Hosoi M, Akai R, Iwawaki T, Ishikawa O, Motegi SI, Sci Rep, 10:1349, 2020
  DOI:10.1038/s41598-020-58452-2
• Inhibitory effect of kaempferol on skin fibrosis in systemic sclerosis by the suppression of oxidative stress, Sekiguchi A, Motegi SI, Fujiwara C, Yamazaki S, Inoue Y, Uchiyama A, Akai R, Iwawaki T, Ishikawa O, J Dermatol Sci, 96:8-17, 2019
  DOI:10.1016/j.jdermsci.2019.08.004
• Zinc deficiency exacerbates pressure ulcers by increasing oxidative stress and ATP in the skin, (Nakamura H), Sekiguchi A, Ogawa Y, Kawamura T, Akai R, Iwawaki T, Makiguchi T, Yokoo S, Ishikawa O, Motegi SI, J Dermatol Sci, 95:62-69, 2019
  DOI:10.1016/j.jdermsci.2019.07.004
• IRE1α governs cytoskeleton remodelling and cell migration through a direct interaction with filamin A, Urra H, Henriquez DR, Cánovas J, Villarroel-Campos D, Carreras-Sureda A, Pulgar E, Molina E, Hazari YM, Limia CM, Alvarez-Rojas S, Figueroa R, Vidal RL, Rodriguez DA, Rivera CA, Court FA, Couve A, Qi L, Chevet E, Akai R, Iwawaki T, Concha ML, Glavic Á, Gonzalez-Billault C, Hetz C, Nat Cell Biol, 20:942-953, 2018
  DOI:10.1038/s41556-018-0141-0
• Botulinum toxin B suppresses the pressure ulcer formation in cutaneous ischemia-reperfusion injury mouse model: Possible regulation of oxidative and endoplasmic reticulum stress, Sekiguchi A, Motegi SI, Uchiyama A, Uehara A, Fujiwara C, Yamazaki S, Perera B, Nakamura H, Ogino S, Yokoyama Y, Akai R, Iwawaki T, Ishikawa O, J Dermatol Sci, 90:144-153, 2018
  DOI:10.1016/j.jdermsci.2018.01.006
• Transgenic mouse model for imaging of ATF4 translational activation-related cellular stress responses in vivo, Iwawaki T, Akai R, Toyoshima T, Takeda N, Ishikawa T, Yamamura K, Sci Rep, 7:46230, 2017
  DOI:10.1038/srep46230
• Protective effect of mesenchymal stem cells on the pressure ulcer formation by the regulation of oxidative and endoplasmic reticulum stress, Motegi SI, Sekiguchi A, Uchiyama A, Uehara A, Fujiwara C, Yamazaki S, Perera B, Nakamura H, Ogino S, Yokoyama Y, Akai R, Iwawaki T, Ishikawa O, Sci Rep, 7:17186, 2017
  DOI:10.1038/s41598-017-17630-5
• Constitutive role of GADD34 and CReP in cancellation of phospho-eIF2α-dependent translational attenuation and insulin biosynthesis in pancreatic β cells, Akai R, Hosoda A, Yoshino M, Iwawaki T, Genes Cells, 20:871-886, 2015
  DOI:10.1111/gtc.12279
• Transgenic mouse model for imaging of interleukin-1β-related inflammation in vivo, Iwawaki T, Akai R, Oikawa D, Toyoshima T, Yoshino M, Suzuki M, Takeda N, Ishikawa TO, Kataoka Y, Yamamura K, Sci Rep, 5:17205, 2015
  DOI:10.1038/srep17205
• Evaluating experimental cerebral malaria using oxidative stress indicator OKD48 mice, Imai T, Iwawaki T, Akai R, Suzue K, Hirai M, Taniguchi T, Okada H, Hisaeda H, Int J Parasitol, 44:681-685, 2014
  DOI:10.1016/j.ijpara.2014.06.002
• A transgenic mouse model for monitoring oxidative stress, Oikawa D, Akai R, Tokuda M, Iwawaki T, Sci Rep, 2:229, 2012
  DOI:10.1038/srep00229
• Positive contribution of Erdj5/JPDI to endoplasmic reticulum protein quality control in the salivary gland, Hosoda A, Tokuda M, Akai R, Kohno K, Iwawaki T, Biochem J, 425:117-125, 2010
  DOI:10.1042/BJ20091269
• Positive contribution of the IRE1α-XBP1 pathway to placental expression of CEA family genes, Oikawa D, Akai R, Iwawaki T, FEBS Lett, 584:1066-1070, 2010
  DOI:10.1016/j.febslet.2010.02.012
• IRE1α disruption causes histological abnormality of exocrine tissues, increase of blood glucose level, and decrease of serum immunoglobulin level, Iwawaki T, Akai R, Kohno K, PLoS ONE, 5:e13052, 2010
  DOI:10.1371/journal.pone.0013052
• Function of IRE1 alpha in the placenta is essential for placental development and embryonic viability, Iwawaki T, Akai R, Yamanaka S, Kohno K, Proc Natl Acad Sci USA, 106:16657-16662, 2009
  DOI:10.1073/pnas.0903775106
• Analysis of the XBP1 splicing mechanism using endoplasmic reticulum stress-indicators, Iwawaki T, Akai R, Biochem Biophys Res Commun, 350:709-715, 2006
  DOI:10.1016/j.bbrc.2006.09.100
• A transgenic mouse model for monitoring endoplasmic reticulum stress, Iwawaki T, Akai R, Kohno K, Miura M, Nat Med, 10:98-102, 2004
  DOI:10.1038/nm970