TSUMOTO Kunichika

Researcher Profile & Settings

Research

Overview of research:
We elucidate the mechanism of lethal arrhythmias using mathematical model constructions and computer simulations. We establish an arrhythmia control theory based on the generative mechanism of arrhythmias.

Association Memberships

• Jan. 2017- Biophysical Society Regular Member
• Apr. 2010- Japanese Heart Rhythm Society
• Apr. 2018- The Physiological Society of Japan
• Apr. 2017- Jananease Pharmacological Society

Academic & Professional Experience

• Aug. 2018Kanazawa Medical University Department of Physiology, Faculty of Medicine Associate Professor
• Apr. 2011- Jul. 2018Graduate School of Medicine, Osaka University Division of Molecular and Cellular Pharmacology, Department of Pharmacology, Graduate School of Medicine Assistant Professor
• Oct. 2010- Mar. 2011Graduate School of Medicine, Osaka University Division of Molecular and Cellular Pharmacology, Department of Pharmacology, Division of Pathophysiology and Therapeutics Assistant Professor

Research Activities

Research Areas

• Complex systems / Basic medicine / Elucidation of mechanisms of lethal arrhytymias and establishement of an arrhythmia control theory
• Medicine,dentistry, and pharmacy / Basic medicine
• Complex systems / Biomedical engineering

Published Papers

• Theoretical prediction of early afterdepolarization-evoked triggered activity formation initiating ventricular reentrant arrhythmias, Kunichika Tsumoto, Takao Shimamoto, Yuma Aoji, Yukiko Himeno, Yuhichi Kuda, Mamoru Tanida, Akira Amano, Yasutaka Kurata, Computer Methods and Programs in Biomedicine, 240:107722, Oct. 2023
  DOI:https://doi.org/10.1016/j.cmpb.2023.107722
• Bifurcations and Proarrhythmic Behaviors in Cardiac Electrical Excitations, Kunichika Tsumoto, Yasutaka Kurata, 12:459, Mar. 2022
  DOI:10.3390/biom12030459
• Specific decreasing of Na+ channel expression on the lateral membrane of cardiomyocytes causes fatal arrhythmias in Brugada syndrome, Kunichika Tsumoto, Takashi Ashihara, Narumi Naito, Takao Shimamoto, Akira Amano, Yasutaka Kurata, Yoshihisa Kurach, Scientific Reports, 10:19964, Nov. 2020
  DOI:10.1038/s41598-020-76681-3
• Multiple Dynamical Mechanisms of Phase-2 Early Afterdepolarizations in a Human Ventricular Myocyte Model: Involvement of Spontaneous SR Ca2+ Release, Yasutaka Kurata, Kunichika Tsumoto, Kenshi Hayashi, Ichiro Hisatome, Yuhichi Kuda, Mamoru Tanida, Frontiers in Physiology, 10:1545, Jan. 2020
  DOI:10.3389/fphys.2019.01545
• Synchronous firing frequency dependence in unidirectional coupled neuronal networks with chemical synapses, (Eri Ioka), Kunichika Tsumoto, Hiroyuki Kitajima, Neurocomputing, 350:202-211, Jul. 2019
• Integrative and theoretical research on the architecture of a biological system and its disorder, (Shinichi Uchida), Yoshiyuki Asai, Yoshiaki Kariya, Kunichika Tsumoto, Hiroshi Hibino, Masashi Honma, Takeshi Abe, Fumiaki Nin, Yasutaka Kurata, Kazuharu Furutani, Hiroshi Suzuki, Hiroaki Kitano, Ryuji Inoue, Yoshihisa Kurachi, Journal of Physiological Sciences, 69:433-451, May 2019
  DOI:10.1007/s12576-019-00667-8
• Facilitation of IKr current by some hERG channel blockers suppresses early afterdepolarizations, (Kazuharu Furutani), Kunichika Tsumoto, I-Shan Chen, Kenichiro Handa, Yuko Yamakawa, Jon T. Sack, Yoshihisa Kurachi, Journal of General Physiology, 151:214-230, Feb. 2019
  DOI:10.1085/jgp.201812192
• Hysteretic dynamics of multi-stable early afterdepolarisations with repolarisation reserve attenuation: a potential dynamical mechanism for cardiac arrhythmias, (Kunichika Tsumoto), Yasutaka Kurata, Kazuharu Furutani, Yoshihisa Kurachi, Scientific Reports, 7:10771, Sep. 2017
  DOI:10.1038/s41598-017-11355-1
• Integrative approach with electrophysiological and theoretical methods reveals a new role of S4 positively charged residues in PKD2L1 channel voltage-sensing, (Tomohiro Numata), Kunichika Tsumoto, Kazunori Yamada, Tatsuki Kurokawa, Shinichi Hirose, Hideki Nomura, Mitsuhiro Kawano, Yoshihisa Kurachi, Ryuji Inoue, Yasuo Mori, Scientific Reports, 7:9760, Aug. 2017
  DOI:10.1038/s41598-017-10357-3
• Dynamical mechanisms of phase-2 early afterdepolarizations in human ventricular myocytes: insights from bifurcation analyses of two mathematical models., Yasutaka Kurata, Kunichika Tsumoto, Kenshi Hayashi, Ichiro Hisatome, Mamoru Tanida, Yu-ichi Kuda, Toshishige Shibamoto, 312:H106-H127, Jan. 2017
  DOI:10.1152/ajpheart.00115.2016
• A Novel Conduction Mechanism Linking Cardiac Action Potentials and Excitation Propagation: Electric Field Mechanism, Kunichika Tsumoto, Yoshihisa Kurachi, 53:138-143, Jun. 2015
  DOI:10.11239/jsmbe.53.138
• Ischemia-related subcellular redistribution of sodium channels enhances the proarrhythmic effect of class I antiarrhythmic drugs: a simulation study., Kunichika Tsumoto, Takashi Ashihara, Ryo Haraguchi, Kazuo Nakazawa, Yoshihisa Kurachi, 9:e109271, Oct. 2014
  DOI:10.1371/journal.pone.0109271
• Bifurcation analyses of nonlinear dynamical systems: From theory to numerical computations., Kunichika Tsumoto, Tetsushi Ueta, Tetsuya Yoshinaga, Hiroshi Kawakami, 3:458, Oct. 2012
  DOI:10.1587/nolta.3.458
• Roles of subcellular Na+ channel distributions in the mechanism of cardiac conduction., Kunichika Tsumoto, Takashi Ashihara, Ryo Haraguchi, Kazuo Nakazawa, Yoshihisa Kurachi, 100:554-563, Feb. 2011
  DOI:10.1016/j.bpj.2010.12.3716
• Modeling light adaptation in circadian clock: prediction of the response that stabilizes entrainment., Kunichika Tsumoto, Gen Kurosawa, Tetsuya Yoshinaga, Kazuyuki Aihara, PloS one, 6:e20880, 2011
  DOI:10.1371/journal.pone.0020880
• Transmural dispersion of repolarization determines scroll wave behavior during ventricular tachyarrhythmias., Ryo Haraguchi, Takashi Ashihara, Tsunetoyo Namba, Kunichika Tsumoto, Shingo Murakami, Yoshihisa Kurachi, Takanori Ikeda, Kazuo Nakazawa, Circulation journal : official journal of the Japanese Circulation Society, 75:80-88, 2011
  DOI:10.1253/circj.CJ-10-0071
• Synchronization of firing in cortical fast-spiking interneurons at gamma frequencies: a phase-resetting analysis., Nathan W Gouwens, Hugo Zeberg, Kunichika Tsumoto, Takashi Tateno, Kazuyuki Aihara, Hugh PC Robinson, 6:e1000951, Sep. 2010
  DOI:10.1371/journal.pcbi.1000951
• Bifurcation analysis on a hybrid systems model of intermittent hormonal therapy for prostate cancer, Gouhei Tanaka, Kunichika Tsumoto, Kunichika Tsumoto, Shigeki Tsuji, Shigeki Tsuji, Kazuyuki Aihara, Kazuyuki Aihara, 237:2616-2627, Oct. 2008
  DOI:10.1016/j.physd.2008.03.044
• Nonlinear dynamics and bifurcations of a coupled oscillator model for calling behavior of Japanese tree frogs (Hyla japonica)., Ikkyu Aihara, Kunichika Tsumoto, 214:6-10, Jul. 2008
  DOI:10.1016/j.mbs.2008.03.004
• Bidirectional modulation of neuronal responses by depolarizing GABAergic inputs., Kenji Morita, Kunichika Tsumoto, Kazuyuki Aihara, 90:1925-1938, Mar. 2006
  DOI:10.1529/biophysj.105.063164
• Bifurcations in a mathematical model for circadian oscillations of clock genes., Kunichika Tsumoto, Tetsuya Yoshinaga, Hitoshi Iida, Hiroshi Kawakami, Kazuyuki Aihara, 239:101-122, Mar. 2006
  DOI:10.1016/j.jtbi.2005.07.017
• Bifurcations in Morris-Lecar neuron model, Kunichika Tsumoto, Kunichika Tsumoto, Hiroyuki Kitajima, Tetsuya Yoshinaga, Kazuyuki Aihara, Kazuyuki Aihara, Hiroshi Kawakami, 69:293-316, Jan. 2006
  DOI:10.1016/j.neucom.2005.03.006
• Possible effects of depolarizing GABAA conductance on the neuronal input-output relationship: a modeling study., Kenji Morita, Kunichika Tsumoto, Kazuyuki Aihara, 93:3504-3523, Jun. 2005
  DOI:10.1152/jn.00988.2004
• Bifurcation of Synchronization Phenomena Observed in a Coupled Neuron Model for Circadian Clock Rhythms, TSUMOTO Kunichika, YOSHINAGA Tetsuya, KAWAKAMI Hiroshi, 87:1516-1528, Jul. 2004
• Bifurcations in synaptically coupled Hodgkin-Huxley neurons with a periodic input, Kunichika Tsumoto, Tetsuya Yoshinaga, Kazuyuki Aihara, Kazuyuki Aihara, Hiroshi Kawakami, 13:653-666, Mar. 2003
  DOI:10.1142/S0218127403006832
• Bifurcations of synchronized responses in synaptically coupled Bonhöffer-van der Pol neurons., Kunichika Tsumoto, Tetsuya Yoshinaga, Hiroshi Kawakami, 65:036230, Mar. 2002
  DOI:10.1103/PhysRevE.65.036230
• Bifurcations in synaptically coupled BVP neurons, Kunichika Tsumoto, Tetsuya Yoshinaga, Hiroshi Kawakami, 11:1053-1064, Apr. 2001
  DOI:10.1142/S0218127401002651
• Bifurcation of a modified BVP circuit model for neurons generating rectangular waves, Kunichika Tsumoto, Tetsuya Yoshinaga, Hiroshi Kawakami, E82-A:1729-1736, Oct. 1999
• Bifurcation of synchronization phenomena observed in a coupled neuron model for circadian clock rhythms, Kunichika Tsumoto, Tetsuya Yoshinaga, Hiroshi Kawakami, 36:1-14, Jul. 2005
  DOI:10.1002/scj.20348
• Cardiac Arrhythmia: Molecular Mechanisms and Therapeutic Strategies, (Yosuke Okamoto), Kunichika Tsumoto, International Journal of Molecular Sciences, 25:13253, Dec. 2024
  DOI:10.3390/ijms252413253

Books etc

• Bifurcation phenomena in cardiac system: Mechanistic analyses and control design of automaticity and arrhythmias
  Handbook Modern Biophysics, Vol. 7, Molecular and Computational Modeling of Cardiac Function (Thomas Jue)
  Kunichika Tsumoto, Yasutaka Kurata
  Springer Nature  Feb. 2025
• Phase-resetting analysis of gamma-frequency synchronization of cortical fast-spiking interneurons using synaptic-like conductance injection.
  Phase response curves in neuroscience: theory, experiment and analysis (N.W. Schultheiss, A.A. Prinz, R.J. Butera)
  (Hugo Zeberg), Nathun W. Gouwens, Kunichika Tsumoto, Takashi Tateno, Kazuyuki Aihara, Hugh P. C. Robinson
    Dec. 2011
• Computational Electrophysiology (A First Course in "In Silico Medicine") (Volume 2)
  A first course in In Silico medicine (Shinji Doi, Junko Inoue, Zhenxing Pan, Kunichika Tsumoto
  Shinji Doi, Junko Inoue, Zhenxing Pan, Kunichika Tsumoto
  Springer  Apr. 2010
• Bifurcations in synaptically coupled Bonheoffer-van der Pol neurons.
  Chaos in Circuits and Systems. (Guanrong Chen, Tetsushi Ueta)
  Kunichika Tsumoto, Tetsuya Yoshinaga, Hiroshi Kawakami
  World Scientific  May 2002
• Editorial, Cardiac Arrhythmia: Molecular Mechanisms and Therapeutic Strategies
  Cardiac Arrhythmia: Molecular Mechanisms and Therapeutic Strategies. (Yosuke Okamoto, Kunichika Tsumoto, Eds)
  (Yosuke Okamoto), Kunichika Tsumoto
  MDPI  Dec. 2024

Awards & Honors

• Dec. 2010 Daiwa Adrian Prizes 2010