SAKAMOTO Takuya
| ■Faculty | Research Support Center | |||
| ■Position | Assistant Professor | |||
Researcher Profile & Settings
Research
Overview of research:
To maximize the therapeutic potential of ADSCs, optimizing the processes from cell harvesting to patient administration is crucial. In particular, advancements in cultivation methods, storage technologies, and administration strategies are essential for maintaining and enhancing the therapeutic efficacy and regenerative capabilities of these cells.
Recent research has focused on improving ADSC characteristics through various cultivation platforms, leading to the development of cell products with superior therapeutic potential. This study specifically focuses on optimizing the cultivation conditions, storage methods, and administration processes of ADSCs, aiming to expand their possibilities for clinical applications.
Association Memberships
- Apr. 2017- Japanese College of Angiology
- Apr. 2018- JAPANESE SOCIETY FOR CIRCULATION RESEARCH
- Apr. 2019- THE JAPAN SOCIETY OF TRANSFUSION MEDICINE AND CELL THERAPY
- Apr. 2012- THE JAPANESE PHARMACOLOGICAL SOCIETY
- Apr. 2019- THE JAPANESE SOCIETY FOR REGENERATIVE MEDICINE
Research Activities
Published Papers
- Multiomics analyses reveal adipose-derived stem cells inhibit the inflammatory response of M1-like macrophages through secreting lactate, Tetsuhiro Horie, Hiroaki Hirata, Takuya Sakamoto, Hironori Kitajima, Atsushi Fuku, Yuka Nakamura, Yumi Sunatani, Ikuhiro Tanida, Hiroshi Sunami, Yoshiyuki Tachi, Yasuhito Ishigaki, Naoki Yamamoto, Yusuke Shimizu, Toru Ichiseki, Ayumi Kaneuji, Kuniyoshi Iwabuchi, Satoshi Osawa, Norio Kawahara, Stem Cell Research & Therapy, 15:485, Dec. 2024
- Investigating the Unexpected Effect of Bulkheads in a Dementia Model of Mice Through Molecular Analysis of the Hippocampus, Takuya Sakamoto, Tadashi Ueda, Tetsuhiro Horie, Daisuke Sakamoto, Yasuo Yoshitomi, Yasuhito Ishigaki, Munenori Ono, Nobuo Kato, Tsugiyasu Kanda, Yuji Kasamaki, Cureus, 16:e72272, Oct. 2024
- A Rare Case of High Takeoff of the Right Coronary Artery from the Ascending Aorta, Daisuke Sakamoto, Takuya Sakamoto, Taishi Fujii, Yasuhiro Nagayoshi, Tamaki Takano, Journal of Coronary Artery Disease, 30:147-150, Oct. 2024
- Abdominal Stent Grafting With Coil Embolization for an Abdominal Aortic Aneurysm Sac With a Short Neck, Daisuke Sakamoto, Takuya Sakamoto, Yasuhiro Nagayoshi, Tamaki Takano, 16:e58988, Apr. 2024
- A novel cell source for therapy of knee osteoarthritis using atelocollagen microsphere-adhered adipose-derived stem cells: Impact of synovial fluid exposure on cell activity, Takuya Sakamoto, Atsushi Fuku, Tetsuhiro Horie, Hironori Kitajima, Yuka Nakamura, Ikuhiro Tanida, Hiroshi Sunami, Hiroaki Hirata, Yoshiyuki Tachi, Yasuo Iida, Sohsuke Yamada, Naoki Yamamoto, Yusuke Shimizu, Yasuhito Ishigaki, Toru Ichiseki, Ayumi Kaneuji, Satoshi Osawa, Norio Kawahara, Regenerative Therapy, 27:408-418, Apr. 2024
- Detecting Human Papillomavirus in Skin Disease Clinical Specimens: Challenges and Methods, Akira Shimizu, Hiroto Ono, Kazushi Anzawa, Sawako Ochiai, Yuko Takamiya, Kiminobu Takeda, Takuya Sakamoto, Sohsuke Yamada, Journal of Kanazawa Medical University, 49:47-51, 2024
- Development of Anticancer Drugs Targeting Aberrant Splicing and Nonsense-Mediated mRNA Decay, Kayoko Yamaguchi, Tetsuhiro Horie, Takuya Sakamoto, Yuka Nakamura, Yasuhito Ishigaki, Togen Masauji, Journal of Kanazawa Medical University, 50:1, 2024
- Septic arthritis of cervical spine facet joints: A case report and review of imaging, Hironori Kitajima, Eiju Hatano, Masahito Kawaguchi, Takuya Sakamoto, Toru Ichiseki, Ayumi Kaneuji, Norio Kawahara, The American journal of case reports, 24:e941578, Oct. 2023
- Synovial fluid derived from human knee osteoarthritis increases the viability of human adipose-derived stem cells through upregulation of FOSL1, Hironori Kitajima, Takuya Sakamoto, Tetsuhiro Horie, Ayane Kuwano, Atsushi Fuku, Yasuhiko Taki, Yuka Nakamura, Ikuhiro Tanida, Hiroshi Sunami, Hiroaki Hirata, Yoshiyuki Tachi, Naoki Yamamoto, Yasuo Iida, Yasuhito Ishigaki, Sohsuke Yamada, Shigetaka Shimodaira, Yusuke Shimizu, Toru Ichiseki, Ayumi Kaneuji, Satoshi Osawa and Norio Kawahara, Cells, 12:330, Jan. 2023
- The Detection of Immunity against WT1 and SMAD4P130L of EpCAM+ Cancer Cells in Malignant Pleural Effusion, Terutsugu Koya, Yo Niida, Misa Togi, Kenichi Yoshida, Takuya Sakamoto, Hiroki Ura, Sumihito Togi, Tomohisa Kato Jr, Sohsuke Yamada, Haruo Sugiyama, Shigeo Koido, Shigetaka Shimodaira, International Journal of Molecular Sciences, 23:12177, Oct. 2022
- Different in vitro-generated MUTZ-3-derived dendritic cell types secrete dexosomes with distinct phenotypes and antigen presentation potencies., Sakamoto T, Koya T, Togi M, Yoshida K, Kato T Jr, Ishigaki Y, Shimodaira S., International Journal of Molecular Sciences, 11:8362, Jul. 2022
- Quality Verification with a Cluster-Controlled Manufacturing System to Generate Monocyte-Derived Dendritic Cells, Haruhiko Kawaguchi, Takuya Sakamoto, Terutsugu Koya, Misa Togi, Ippei Date, Asuka Watanabe, Kenichi Yoshida, Tomohisa Kato, Yuka Nakamura, Yasuhito Ishigaki, Shigetaka Shimodaira, Vaccines, 9:533, May 2021
- Identification of CD56 dim subpopulation marked with high expression of GZMB/PRF1/PI-9 in CD56 + interferon-α-induced dendritic cells, Asuka Watanabe, Misa Togi, Terutsugu Koya, Makoto Taniguchi , Takuya Sakamoto, Kuniyoshi Iwabuchi, Tomohisa Kato, Shigetaka Shimodaira, Genes to cells, 26:313-327, May 2021
- A Retinoic Acid-β2‐Receptor Agonist Exerts Cardioprotective Effects, 35:S1, Mar. 2021
- Interferon-α-Induced Dendritic Cells Generated with Human Platelet Lysate Exhibit Elevated Antigen Presenting Ability to Cytotoxic T Lymphocytes, Date I, Koya T, Sakamoto T, Togi M, Kawaguchi H, Watanabe A, Kato T Jr, Shimodaira S, Vaccines, 9:10, 2021
- Dendritic Cells Pre-Pulsed With Wilms' Tumor 1 in Optimized Culture for Cancer Vaccination, Terutsugu Koya, Ippei Date, Haruhiko Kawaguchi, Asuka Watanabe, Takuya Sakamoto, Misa Togi, Tomohisa Kato Jr, Kenichi Yoshida, Shunsuke Kojima, Ryu Yanagisawa, Shigeo Koido, Haruo Sugiyama , Shigetaka Shimodaira, Pharmaceutics, 12:305, Mar. 2020
- In Vivo Administration of Recombinant Human Granulocyte Colony-Stimulating Factor Increases the Immune Effectiveness of Dendritic Cell-Based Cancer Vaccination, Shimodaira S, Yanagisawa R, Koya T, Hirabayashi K, Higuchi Y, Sakamoto T, Togi M, Kato T Jr, Kobayashi T, Koizumi T, Koido S, Sugiyama H, Vaccines (Basel), 7:120, Sep. 2019
- Regulatory Role of GRK2 in the TLR Signaling-Mediated iNOS Induction Pathway in Microglial Cells., Palikhe S, Ohashi W, Sakamoto T, Hattori K, Kawakami M, Andoh T, Yamazaki H, Hattori Y, Frontiers in pharmacology, 10:59, Feb. 2019
- Cardioprotective and functional effects of levosimendan and milrinone in mice with cecal ligation and puncture-induced sepsis., Yamashita S, Suzuki T, Iguchi K, Sakamoto T, Tomita K, Yokoo H, Sakai M, Misawa H, Hattori K, Nagata T, Watanabe Y, Matsuda N, Yoshimura N, Hattori Y, 391:1021-1032, Sep. 2018
- Anti-inflammatory properties of cilostazol: Its interruption of DNA binding activity of NF-κB from the Toll-like receptor signaling pathways., Sakamoto T, Ohashi W, Tomita K, Hattori K, Matsuda N, Hattori Y, International immunopharmacology, 62:120-131, Sep. 2018
- Selective A Retinoic Acid β2-Receptor Agonist Exerts Cardioprotective Effects., Marino A, Sakamoto T, Tang XH, Gudas LJ, Levi R, The Journal of pharmacology and experimental therapeutics, 366:314-321, Aug. 2018
- S1P receptor 1-Mediated Anti-Renin-Angiotensin System Cardioprotection: Pivotal Role of Mast Cell Aldehyde Dehydrogenase Type 2., Marino A, Sakamoto T, Robador PA, Tomita K, Levi R, The Journal of pharmacology and experimental therapeutics, 362:230-242, Aug. 2017
- Anti-Inflammatory Profile of Levosimendan in Cecal Ligation-Induced Septic Mice and in Lipopolysaccharide-Stimulated Macrophages., Wang Q, Yokoo H, Takashina M, Sakata K, Ohashi W, Abedelzaher LA, Imaizumi T, Sakamoto T, Hattori K, Matsuda N, Hattori Y, Critical care medicine, 43:e508-20, Nov. 2015