FacultyDepartment of Hepatology, Regenerative Medicine Center

Researcher Profile & Settings


    Overview of research:
    Mechanism of alcoholic liver disease


  • Kanazawa Medical University Faculty of Medicine


  • Ph.D in Medicine

Research Activities

Published Papers

  • Inhibition of γ-glutamyltransferase ameliorates ischemia-reoxygenation tissue damage in rats with hepatic steatosis, Ryuichi Kubota, Nobuhiko Hayashi, Kaori Kinoshita, Takashi Saito, Kazuaki Ozaki, Yoshimichi Ueda, Mutsumi Tsuchishima, Mikihiro Tsutsumi, Joseph George, British Journal of Pharmacology177:5195-5207Nov. 2020
  • Metabolism of N-nitrosodimethylamine, methylation of macromolecules, and development of hepatic fibrosis in rodent models, Joseph George, Mutsumi Tsuchishima, Mikihiro Tsutsumi, Journal of Molecular Medicine98:1203-1213Sep. 2020
  • Recombinant thrombomodulin prevented hepatic ischemia-reperfusion injury by inhibiting high-mobility group box 1 in rats, Yuki Hirakawa, Mutsumi Tsuchishima, Atsushi Fukumura, Kaori Kinoshita, Nobuhiko Hayashi, Takashi Saito, Joseph George, Toshikuni Nobuyuki, Ueda Yoshimichi, Tsutsumi Mikihiro, European Journal of Pharmacology863:172681Dec. 2019
  • The combination of fatty liver and increased gamma-glutamyl transpeptidase levels as a risk factor for atherosclerotic plaque development in apparently healthy people, Kaori Kinoshita, Nobuyuki Toshikuni, Takashi Saito, Nobuhiko Hayashi, Takahiro Minato, Yasuhiro Matsue, Yoshimichi Ueda, Mutsumi Tsuchishima, Mikihiro Tsutsumi, Turkish Journal of Medical Scences49:1350-1357Oct. 2019
  • Alteration of Trace Elements during Pathogenesis of N-Nitrosodimethylamine Induced Hepatic Fibrosis, Joseph George, Mikihiro Tsutsumi, Mutsumi Tsuchishima, Scientific Reports9:708Jan. 2019
  • Molecular mechanisms in the pathogenesis of N-nitrosodimethylamine induced hepatic fibrosis, Joseph George, Mutsumi Tsuchishima, Mikihiro Tsutsumi, Cell Death & Disease10:18Jan. 2019
  • Toxic AGEs (TAGE) theory for pathophysiology of the onset / progression of NAFLD and ALD, Akiko Sakasai-Sakai, Jun-ichi Takano, Atsushi Fukumura, Takanobu Takata, Mikihiro Tsutsumi, Masayoshi Takeuchi, The journal of Japan Mibyo System Association24:19-25Mar. 2018
  • MMP-13 deletion decreases profibrogenic molecules and attenuates N-nitrosodimethylamine-induced liver injury and fibrosis in mice, George, Joseph;Tsutsumi, Mikihiro;Tsuchishima, Mutsumi, JOURNAL OF CELLULAR AND MOLECULAR MEDICINE21:3821-3835Dec. 2017
  • An image fusion system for estimating the therapeutic effects of radiofrequency ablation on hepatocellular carcinoma, Toshikuni, Nobuyuki;Matsue, Yasuhiro;Ozaki, Kazuaki;Yamada, Kaho;Hayashi, Nobuhiko;Tsuchishima, Mutsumi;Tsutsumi, Mikihiro, RADIOLOGY AND ONCOLOGY51:263-269Sep. 2017
  • Toxic AGE (TAGE) Theory for the Pathophysiology of the Onset/Progression of NAFLD and ALD, Masayoshi Takeuchi, Jun-ichi Takino, Akiko Sakasai-Sakai, Takanobu Takata, Mikihiro Tsutsumi, Nutrients9:634Jun. 2017
  • Associations of Fatty Liver Disease with Hypertension, Diabetes, and Dyslipidemia: Comparison between Alcoholic and Nonalcoholic Steatohepatitis, Toshikuni, Nobuyuki;Tsuchishima, Mutsumi;Fukumura, Atsushi;Arisawa, Tomiyasu;Tsutsumi, Mikihiro, GASTROENTEROLOGY RESEARCH AND PRACTICE2017:91278472017
  • Management of gastroesophageal varices in cirrhotic patients: current status and future directions., N.Toshikuni, Y.Takuma, M.Tsutsumi, Annals of hepatology15:314-325May 2016
  • Mural nodule of 10 mm or larger as predictor of malignancy for intraductal papillary mucinous neoplasm of the pancreas: Pathological and radiological evaluations., (N.Kawada), H.Uehara, S.Nagata, M.Tsuchishima, M.Tsutsumi, Y.Tomita, Pancreatology16:441-4482016
  • GGsTop, a novel and specific γ-glutamyl transpeptidase inhibitor, protects hepatic ischemia-reperfusion injury in rats., K.Tamura, N.Hayashi, J.George, M.Toshikuni, T.Arisawa, J.Hiratake, M.Tsuchishima, M.Tsutsumi, American journal of physiology. Gastrointestinal and liver physiology311:G305-G3122016
  • Toxic AGEs (TAGE) theory in the pathogenesis of NAFLD and ALD, M.Takeuchi, A.Sakasai-Sakai, J.Takino, T.Takata, T.Ueda, M.Tsutsumi, International Journal of Diabetes and Clinical Researsh2:1-5Jul. 2015
  • Elevated serum gamma-glutamyl transpeptidase levels and fatty liver strongly predict the presence of carotid plaque, N.Toshikuni,T.Asaji,Y.Nakanishi,SY.Nagasawa,H.Uenishi,M.Tsutsumi, Journal of Atherosclerosis and Thrombosis22:1051-1060Feb. 2015
  • Serum osteopontin predicts degree of hepatic fibrosis and serves as a biomarker in patients with hepatitis C virus Infection, Y.Matsue, M.Tsutsumi, N.Hayashi, T.Saito, M.Tsuchishima, N.Toshikuni, T.Arisawa, J.George, PLoS One10:e0118744-e01187442015
  • Serum endocan as a survival predictor for patients with liver cirrhosis, N.Toshikuni, K.Ozaki, J.George, M.Tsutsumi, Canadian Journal of Gastroenterology and Hepatology29:427-4302015
  • Imaging morphological changes of intraductal papillary mucinous neoplasm of the pancreas was associated with its malignant transformation but not with development of pancreatic ductal adenocarcinoma, N.Kawada, H.Uehara, S.Nagata, M.Tsuchishima, M.Tsutsumi, Y.Tomita, Pancreatology15:654-6602015
  • Involvement of the TAGE-RAGE system in non-alcoholic steatohepatitis: Novel treatment strategies., M.Takeuchi, J.Takino, A.Sakasai-Sakai, T.Takata, T.Ueda, M.Tsutsumi, H.Hyogo, S.Yamagishi, World journal of hepatology [electronic resource]6:880-893Dec. 2014
  • Pathogenesis of alcoholic chronic hepatitis, N.Hayashi, T.Saito, M.Kakuda, Y.Matsue, T.Minato, A.Fukumura, K.Ozaki, M.Tsuchisima, M.Tsutsumi49:219-226Oct. 2014
  • Clinical differences between alcoholic liver disease and nonalcoholic fatty liver disease, N.Toshikuni, M.Tsutsumi, T.Arisawa, World journal of gastroenterology : WJG.20:8393-8406Jul. 2014
  • Nutrition and exercise in the management of liver cirrhosis, N.Toshikuni, T.Arisawa, M.Tsutsumi, World journal of gastroenterology : WJG.20:7286-7297Jun. 2014
  • Hepatitis C-related liver cirrhosis - strategies for the prevention of hepatic decompensation,hepatocarcinogenesis,and mortality, N.Toshikuni, T.Arisawa, M.Tsutsumi, World journal of gastroenterology : WJG.20:2876-2887Mar. 2014
  • Serum endocan as a novel prognostic biomarker in patients with hepatocellular carcinoma, K.Ozaki, N.Toshikuni, J.George, T.Minato, Y.Matsue, T.Arisawa, M.Tsutsumi, Journal of Cancer [electronic resource]5:221-2302014
  • Real-time image fusion for successful percutaneous radiofrequency ablation of hepatocellular carcinoma., N.Toshikuni, M.Tsutsumi, Y.takuma, T.Arisawa, Journal of ultrasound in medicine : official journal of the American Institute of Ultrasound in Medicine.33:2005-20102014
  • Binge alcohol consumption aggravates oxidative stress and promotes pathogenesis of NASH from obesity-lnduced simple steatosis, T.Minato, M.Tsutsumi, M.Tsuchishima, N.Hayashi, T.Saito, Y.Matsue, N.Toshikuni, T.Arisawa, J.George, Molecular medicine (Cambridge, Mass.)20:490-5022014
  • Chronic ingestion of ethanol induces hepatocellular carcinoma in mice without additional hepatic insult., M.Tsuchishima, J.George, H.Shiroeda, T.Arisawa, T.Takegami, M.Tsutsumi, Digestive diseases and sciences.58:1923-1933Jul. 2013
  • Acetaldehyde-derived advanced glycation end-products promote alcoholic liver disease., N.Hayashi, J.George, M.Takeuchi, A.Fukumura, N.Toshikuni, T.Arisawa, M.Tsutsumi, PloS one8:e70034;1-14Jul. 2013
  • Irsogladine maleate for the treatment of recurrent aphthous stomatitis in hepatitis C virus patients on pegylated-interferon and ribavirin: a pilot study., N.Hayashi, J.George, H.Shiroeda, T.Saito, N.Toshikuni, M.Tsuchishima, T.Arisawa, M.Tsutsumi, Journal of gastroenterology and hepatology.28:1015-1018Jun. 2013
  • Portal venular constriction during anaphylactic shock in anesthetized rats., M.Kitadate, T.Shibamoto, M.Tsutsumi, H.Tonami, Biomedical research (Tokyo, Japan)34:61-68Apr. 2013
  • Comparison of the relationships of alcoholic and nonalcoholic fatty liver with hypertension,diabetes mellitus,and dyslipidemia., N.Toshikuni, A.Fukumura, N.Hayashi, T.Nomura, M.Tsuchishima, T.Arisawa, M.Tsutsumi, Journal of clinical biochemistry and nutrition52:82-88Jan. 2013
  • Influence of IL17A polymorphisms (rs2275913 and rs3748067) on the susceptibility to ulcerative colitis, R.Hayashi, T.Tahara, H.Shiroeda, T.Saito, M.Nakamura, M.Tsutsumi, T.Shibata, T.Arisawa, Clinical and experimental medicine13:239-2442013
  • Advanced ultrasonography technologies to assess the effects of radiofrequency ablation on hepatocellular carcinoma., N.Toshikuni, H.Shiroeda, K.Ozaki, Y.Matsue, T.Minato, T.Nomura, N.Hayashi, T.Arisawa, M.Tsutsumi, Radiology and oncology.47:224-2292013
  • Mast cells are not involved in the ischemia-reperfusion injury in perfused rat liver, T.Shibamoto, M.Tsutsumi, Y.Kuda, C.Ohmukai, W.Zhang, Y.Kurata, The Journal of surgical research174:114-119May 2012
  • Accelerated progression of hepatocellular carcinoma with cytokeratin 19 expression during treatment with lamivudine for hepatitis B virus-related liver cirrhosis, M.Yamada, H.Shiroeda, K.Sato, R.Hayashi, T.Nomura, M.Tsutsumi, T.Arisawa, Scandinavian journal of gastroenterology45:249-251May 2011
  • Survival rates of early-stage HCV-related liver cirrhosis patients without hepatocellular carcinoma are decreased by alcohol, M.Yamada, H.Shiroeda, R.Hayashi, H.Yano, K.Sato, M.Tsutsumi, T.Arisawa, Journal of clinical biochemistry and nutrition48:167-169Mar. 2011
  • Ethanol predominantly constricts pre-sinusoids of isolated perfused livers of rat, guinea pig and mouse, T.Shibamoto, M.Tsutsumi, C.Omukai, Y.Kuda, W.Zhang, Y.Kurata, Alcohol and alcoholism : international journal of the Medical Council on Alcoholism.46:117-1222011
  • Colon cancer arising in an ulcer scar due to intestinal Behcet's disease, M.Yamada, H.Shiroeda, T.Nomura, R.Hayashi, K.Sato, M.Tsutsumi, T.Arisawa, Internal medicine (Tokyo, Japan)50:429-322011
  • Association between functional promoter polymorphisms of macrophage migration inhibitory factor(MIF)gene and ulcerative colitis in Japan, H.Shiroeda, T.Tahara, M.Nakamura, T.Shibata, T.Nomura, H.Yamada, R.Hayashi, T.Saito, M.Yamada, T.Fukuyama, T.Otsuka, H.Yano, K.Ozaki, M.Tsuchishima, M.Tsutsumi, T.Arisawa, Cytokine.51:173-177May 2010
  • A case ob jejunal GIST diagnosed by double-baloon endoscopy, S.Siroeda, H.Siroeda, T.Ootsuka, M.Yamada, T.Fukuyama, T.Saito, R.Hayashi, T.Nomura, H.Yano, K.Ozaki, T.Arisawa, M.Yokoi, T.Kosaka, M.Tsutsumi, ENDOSCOPIC FORUM for digestive disease26:44-492010
  • Functional promoter polymorphisms of macrophage migration inhibitory factor in peptic ulcer diseases, H.Shiroeda, T.Tahara, M.Nakamura, T.Shibata, H.Yamada, T.Nomura, R.Hayashi, T.saito, T.Fukuyama, T.Otsuka, H.Yano, K.Ozaki, M.Tsuchishima, M.Tsutsumi, T.Arisawa, International journal of molecular medicine26:707-7112010
  • Cholangiocarcinoma producig parathyroid hoemone-related peptide treated with chemoradiation usig gemcitabine and S-1, M.Yamada, H.Shiroeda, S.Shiroeda, K.Sato, T.Arisawa, M.Tsutsumi, Internal medicine (Tokyo, Japan)48:2097-2100Dec. 2009
  • Mouse hepatic portal venoconstrictive response to vasoconstrictors is much weaker than that in rat, ZS.Zhao, T.Shibamoto, M.Tsutsumi, S.Cui, WM.Zhang, H.Takano, Y.Kurata, Journal of cardiovascular pharmacology.54:421-4262009
  • Surgical implanation of human adipose derived stem cells attenuates experimentally induced hepatic fibrosis in rats28: 143:s10020-022-00566-6Nov. 2022

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