Japanese

HIMEDA Toshiki

■Faculty	Department of Microbiology
■Position	Associate Professor

Researcher Profile & Settings

Research

Overview of research:

We study the mechanism of persistent infection and pathogenesis of Theilovirus (Theiler(s) virus and Saffold virus). We investigate and analyze each virus protein(s) role in viral growth and their effects on the host from various angles, aiming to understand the relationship between virus infection and diseases such as autoimmune diseases and diabetes.

Education

The University of Tokushima Graduate School

Degree

Doctor of Pharmacy

Research Activities

Published Papers

Virus-infection in cochlear supporting cells induces audiosensory receptor hair cell death by TRAIL-induced necroptosis., (Hayashi Yushi);Suzuki Hidenori;Nakajima Wataru;Uehara Ikuno;Tanimura Atsuko;Himeda Toshiki;Koike Satoshi;Katsuno Tatsuya;Kitajiri Shin-Ichiro;Koyanagi Naoto;Kawaguchi Yasushi;Onomoto Koji;Kato Hiroki;Yoneyama Mitsutoshi;Fujita Takashi;Tanaka Nobuyuki, PloS one, 16:e0260443, 2021
DOI:10.1371/journal.pone.0260443
Cochlear supporting cells function as macrophage-like cells and protect audiosensory receptor hair cells from pathogens, (Yushi Hayashi), Hidenori Suzuki, Wataru Nakajima, Ikuno Uehara, Atsuko Tanimura, Toshiki Himeda, Satoshi Koike, Tatsuya Katsuno, Shin-ichiro Kitajiri, Naoto Koyanagi, Yasushi Kawaguchi, Koji Onomoto, Hiroki Kato, Mitsutoshi Yoneyama, Takashi Fujita, Nobuyuki Tanaka, Scientific reports, 10:6740, Apr. 2020
DOI:https://doi.org/10.1038/s41598-020-63654-9
The epitope sequence of S16, a monoclonal antibody against influenza C virus hemagglutinin-esterase fusion glycoprotein, Okuwa, Takako;Sasaki, Yutaka;Matsuzaki, Yoko;Himeda, Toshiki;Yoshino, Naoto;Hongo, Seiji;Ohara, Yoshiro;Muraki, Yasushi, FUTURE VIROLOGY, 12:93-101, Mar. 2017
DOI:10.2217/fvl-2016-0105
Saffold Cardiovirus Infection in a 2-Year-Old Boy with Acute Pancreatitis, (Ito, Hisato);Miyagaki, Satoshi;Sakaue, Satoshi;Matsui, Fumihiro;Katsumi, Yoshiki;Otabe, Osamu;Torii, Jun;Itagaki, Tsutomu;Himeda, Toshiki;Okuwa, Takako;Ohara, Yoshiro, JAPANESE JOURNAL OF INFECTIOUS DISEASES, 70:105-107, Jan. 2017
DOI:10.7883/yoken.JJID.2015.488
Role(s) of leader protein of saffold virus., (A.Shimizu), T.Himeda, T.Okuwa, Y.Muraki, Y.Ohara, Clinical & experimental neuroimmunology [electronic resource], 5:362-366, 2014
Topics of human cardioviruses., Y.Ohara, T.Himeda, 25:446-451, 2013
Saffold virus type 3 (SAFV-3) persists in HeLa cells., T.Himeda, T.Hosomi, T.Okuwa, Y.Muraki, Y.Ohara, PloS one, 8:e53194;1-8, 2013
Possibility of neuropathogenesis of Saffold virus suggested from the in vitro virus persistence., T.Himeda, T.Okuwa, Y.Muraki, Y.Ohara, Clinical & experimental neuroimmunology [electronic resource], 4:163-164, 2013
Effect of cysteine mutations in the extracellular domain of CM2 on the Influenza C virus replication., Y.Muraki, T.Okuwa, T.Himeda, S.Hongo, Y.Ohara, PloS one, 8:e60510;1-10, 2013
Saffold virus, a novel human cardiovirus with unknown pathogenicity, T.Himeda, Y.Ohara, Journal of virology., 86:1292-1296, 2012
Glycosylation of CM2 is important for efficient replication of influenza C virus, T.Okuwa, Y.Muraki, T.Himeda, Y.Ohara, Virology., 433:167-175, 2012
Reverse genetic analysis of the recombination in theilovirus based on the infectious cDNA clones, T.Himeda, M.Nojiri, T.Okuwa, Y.Muraki, Y.Ohara, Journal of Plant Pathology & Microbiology, 0.086111111, Dec. 2011
A new member of Cardiovirus: Unknown pathogenicity to humans, Y.Ohara, T.Himeda, Journal of Plant Pathology & Microbiology, 0.086111111, Dec. 2011
Roles of two non-structural viral proteins in virus-induced demyelination, T.Himeda, Y.Ohara, Clinical & experimental neuroimmunology [electronic resource], 2:49-58, May 2011
The Preparation of an infectious full-length cDNA clone of saffold virus, T.Himeda, T.Hosomi, N.Asif, H.Shimizu, T.Okuwa, Y.Muraki, Y.Ohara, Virology journal [electronic resource], 0.409722222, Feb. 2011
Palmitoylation of CM2 is dispensable to influenza C virus replication, Y.Muraki, T.Okuwa, T.Furukawa, Y.Matsuzaki, K.Sugawara, T.Himeda, S.Hongo, Y.Ohara, Virus research., 157:99-105, Feb. 2011
The anti-apoptotic protein L* of Theiler’s murine encephalomyelitis virus (TMEV) contains a mitochondrial targeting signal, T.Himeda, T.Okuwa, M.Nojiri, Y.Muraki, Y.Ohara, Virus research., 155:381, 2011
Opposite effects of two nonstructural proteins of Theiler’s murine encephalomyelitis virus regulates apoptotic cell death in BHK-21 cells, T.Okuwa, N.Taniura, M.Saito, T.Himeda, Y.Ohara, Microbiology and immunology., 54:639-643, Jul. 2010
Cytokine/chemokine profile in J774 macrophage cells persistently infected with DA strain of Theiler's murine encephalomyelitis virus (TMEV), T.Himeda, T.Okuwa, Y.Muraki, Y.Ohara, Journal of neurovirology., 16: 219-229, Jun. 2010
Leader(L) of Theiler's murine encephalomyelitis virus (TMEV) is required for virus growth in a murine macrophage-like cell line, K.Ichinose-Asakura, N.Taniura, T.Himeda, M.Nojiri, T.Okuwa, Y.Ohara, Virus research., 147:224-230, Feb. 2010
Regulation of mitochondrial morphology and cell survival by Mitogenin I and mitochondrial single-stranded DNA binding protein., (Arakaki N), Nishihama T, Kohda A, Owaki H, Kuramoto Y, Abe R, Kita T, Suenaga M, 姫田　敏樹, Kuwajima M, Shibata H, Higuti T, Biochim. Biophys. Acta., 1760: 1364-1372, 2006
Identification of the up- and down-regulated genes in the heart of juvenile visceral steatosis mice., Biol. Pharm. Bull., 27: 496-503, 2004
Generation of a recombinant Saffold Virus expressing UnaG as a marker for the visualization of viral infection., Takako Okuwa, Tosiki Himeda, koichi Utani, Masaya Higuchi, 20:175, Aug. 2023
DOI:10.1186/s12985-023-02142-8
Theilovirus 3C Protease Cleaves the C-Terminal Domain of the Innate Immune RNA Sensor, Melanoma Differentiation-Associated Gene 5, and Impairs Double-Stranded RNA-Mediated IFN Response, (Masahiko Miyamoto), Toshiki Himeda, Kazuki Ishihara, Takako Okuwa, Daiki Kobayashi, Masaaki Nameta, Yu Karasawa, Benyapa Chunhaphinyokul, Yutaka Yoshida, Nobuyuki Tanaka, Masaya Higuchi, Akihiko Komuro, The Journal of Immunology, 210:335, Feb. 2023
DOI:10.4049/jimmunol.2200565
Chronic encephalomyelitis virus exhibits cellular tropism and evades pDCs by binding to sialylated integrins as the cell surface receptors, (Takeda K), Kaifu T, Michihata R, Kinugawa N, Fujioka A, Tateno A, Toshima K, Kanoh H, Inamori KI, Kamijo K, Himeda T, Ohara Y, Inokuchi JI, Nakamura A., Eur J Immunol, 53:e2350452, Oct. 2023

Note: Performance information for the past 1-2 years may be revised at a later date due to inspections conducted by the committee from July to September every year.