Japanese

SHIGA Hideaki

■Faculty	Department of Otorhinolaryngology
■Position	Associate Professor

Researcher Profile & Settings

Research

Overview of research:

Clinical objective test to evaluate olfactory function has not been established. We have created an in vivo imaging system using nasal administration of 201Tl and imaging with a gamma camera and radiography (201Tl olfacto-scintigraphy) to visualize the regeneration of olfactory nerves in rodents. in rats. Nasal administration of 201TlCl solution has the potential to be used clinically for the objective assessment of damage to olfactory nerves.

Special Field

Otorhinolaryngology

Education

Kanazawa University Graduate School Division of Medicine

Degree

Ph.D in Medicine

Association Memberships

2011Japanese Society of Allergology
1995The Oto-Rhino-Laryngological Society of Japan
2006Japanese Rhinologic Society
2009Japanese Society for Molecular Imaging
2006Association for Chemoreception Sciences Regular member

Academic & Professional Experience

Apr. 1995Kanazawa University Hospital Resident
Apr. 1997Georgetown University Medical Center Visiting Fellow
Apr. 2003National Institutes of Health (U.S.A.) Research Scholar
Jan. 2007Kanazawa University Hospital Assistant Professor
Jun. 2009Kanazawa Medical University Senior Assistant Professor
Jul. 2013Kanazawa Medical University Associate Professor

Research Activities

Published Papers

Relationship between olfactory disturbance after acute ischemic stroke and latent thalamic hypoperfusion, (Kazuhiro Okamoto), Hideaki Shiga, Hisako Nakamura, Makoto Matsui, Takaki Miwa, Chemical Senses, 45:111-118, Feb. 2020
The impact of ovariectomy on olfactory neuron regeneration in mice, Kentaro Yamada, Hideaki Shiga, Takuya Noda, Masayuki Harita, Tomoko Ishikura, Yukari Nakamura, Toshihisa Hatta, Hiromi Sakata-Haga, Hiroki Shimada, Takaki Miwa, Chemical Senses, 45:203-209, Feb. 2020
Thallium-201 imaging in intact olfactory sensory neurons with reduced pre-synaptic inhibition in vivo, Hideaki Shiga, Hiroshi Wakabayashi, Kohshin Washiyama, Tomohiro Noguchi, Tomo Hiromasa, Sadaharu Miyazono, Masami Kumai, Kazuma Ogawa, Junichi Taki, Seigo Kinuya, Takaki Miwa, Moleculer Neurobiology, 57:4989-4999, Aug. 2020
Clinical practice guidelines for the management of olfactory dysfunction - Secondary publication, Miwa T, Ikeda K, Ishibashi T, Kobayashi M, Kondo K, Matsuwaki Y, Ogawa T, Shiga H, Suzuki M, Tsuzuki K, Furuta A, Motoo Y, Fujieda S, Kurono Y, Auris Nasus Larynx, 46:653-662, Oct. 2019
Effects of tokishakuyakusan on regeneration of murine olfactory neurons in vivo and in vitro, Takuya Noda, Hideaki Shiga, Kentaro Yamada, Masayuki Harita, Yukari Nakamura, Tomoko Ishikura, Masami Kumai, Zenji Kawakami, Atsushi Kaneko, Toshihisa Hatta, Hiromi Sakata-Haga, Hiroki Shimada, Takaki Miwa, Chemical Senses, 44:327-338, May 2019
Association of olfactory impairment with indexes of sarcopenia and frailty in community-dwelling older adults, Harita M, Miwa T, Shiga H, Yamada K, Sugiyama E, Okabe Y, Miyake Y, Okuno T, Iritani O, Morimoto S, Geriatrics & Gerontology International, 19:384-391, May 2019
Nasal thallium-201 uptake in patients with parosmia with and without hyposmia after upper respiratory tract infection, Shiga H, Okuda K, Taki J, Watanabe N, Tonami H, Kinuya S, Miwa T, International forum of allergy & rhinology, 9:1252-1256, Nov. 2019
Prognostic value of olfactory nerve damage measured with thallium-based olfactory imaging in patients with idiopathic olfactory dysfunction., Shiga Hideaki;Taki Junichi;Okuda Koichi;Watanabe Naoto;Tonami Hisao;Nakagawa Hideaki;Kinuya Seigo;Miwa Takaki, Scientific reports, 7:1, 2017
DOI:10.1038/s41598-017-03894-4
Nasal drug delivery facilitates molecular imaging of olfactory disorders., H.Shiga, T.Miwa, Nihon Bika Gakkai Kaishi (Japanese Journal of Rhinology), 54:47-51, 2015
Reduced nasal transport of insulin-like growth factor-1 to the mouse cerebrum with olfactory bulb resection., H.Shiga, M.Nagaoka, K.Washiyama, J.Yamamoto, K.Yamada, T.Noda, M.Harita, R.Amano, T.Miwa, Chemical senses., 39:595-599, Sep. 2014
Rapamycin downregulates thymidylate synthase and potentiates the activity of pemetrexed in non-small cell lung cancer., (S.Kawabata), CT.Chiang, J.Tsurutani, H.Shiga, ML.Arwood, T.Komiya, JJ.Gills, RM.Memmott, PA.Dennis, Oncotarget [electronic resource], 5:1062-1070., Feb. 2014
Combinations of two odorants of smell identification test for screening of olfactory impairment., H.Shiga, J.Yamamoto, M.Kitamura, H.Nakagawa, T.Matsubasa, A.Seo, T.Miwa, Auris, nasus, larynx., 41:523-527, 2014
Post-traumatic olfactory impairment, H.Shiga, 45:278-281, Jul. 2013
Biological safety of nasal thallium-201 administration: a preclinical study for olfacto-scintigraphy, (K.Washiyama), H.Shiga, K.Hirota, A.Tsuchida, J.Yamamoto, S.Yagi, T.Yoshizaki, M.Furukawa, R.Amano, T.Miwa, Journal of radiation research, 52:450-455, May 2011
Evaluation of the olfactory nerve transport function by SPECT-MRI fusion image with nasal thallium-201 administration, H.Shiga, J.Taki, M.Yamada, K.Washiyama, R.Amano, Y.Matsuura, O.Matsui, S.Tatsutomi, S.Yagi, A.Tsuchida, T.Yoshizaki, M.Furukawa, S.Kinuya, T.Miwa, Molecular imaging and biology : MIB : the official publication of the Academy of Molecular Imaging, 13:1262-1266, Dec. 2010
A case of recurrent frontal sinusitis -The usefulness of Mini-Trephine-, K.Yamada, H.Shiga, J.Yamamoto, T.Miwa, 53:327-330, Oct. 2010
Use of thallium transport to visualize functional olfactory nerve regeneration in vivo, H.Shiga, K.Washiyama, K.Hirota, R.Amano, M.Furukawa, T.Miwa, Rhinology, 47:460-464, Dec. 2009
Usefulness of curry odorant of odor stick identification test for Japanese in olfactory impairment screening, H.Shiga, H.Toda, T.Kobayakawa, S.Saito, K.Hirota, T.Tsukatani, M.Furukawa, T.Miwa, Acta oto-laryngologica., 129(Suppl.562):91-94, Jun. 2009
Odor detection ability and thallium-201 transport in the olfactory nerve of traumatic olfactory-impaired mice., H.Shiga, Y.Kinoshita, K.Washiyama, R.Amano, K.Hirota, T.Tsukatani, M.Furukawa, T.Miwa, Chemical senses., 33: 633-637, Sep. 2008
Olfactory and taste dysfunctions caused by COVID-19: a nationwide study, Takaki MIwa, Eri Mori, Rumi Sekine, Yurika Kimura, Masayoshi Kobayashi, Hideaki Shiga, Kenzo Tsuzuki, Motohiko Suzuki, Kenji Kondo, Isao Suzaki, Go Inokuchi, Tsunemasa Aiba, Kyoko Chujo, Sayaka Yagi-Nakanishi, Toshiaki Tsukatani, Hiroki Nakanishi, Muneko Nishijyo, Yoshitsugu Iinuma, Akihito Yokoyama, Rhinology, 61:552-560, Jan. 2023
Olfactory regeneration with nasally administered murine adipose-derived stem cells in olfactory epithelium damaged mice, Tomoko Ishikura, Hideaki Shiga, Yuka Nakamura, Takako Kanitani, Yasuhito Ishigaki and Takaki MIwa, Cells, Cells 2023:765, Feb. 2023

Note: Performance information for the past 1-2 years may be revised at a later date due to inspections conducted by the committee from July to September every year.