HASHIZUME Chieko

■FacultyDepartment of Hepatology
■PositionAssistant Professor

Researcher Profile & Settings

Research

    Overview of research:
    Elucidation of the mechanism of alcoholic liver injury and search for therapeutic methods using rat models and human specimens.

Research Activities

Published Papers

  • Deficiency of sphingomyelin synthase 2 prolongs survival by the inhibition of lymphoma infiltration through ICAM-1 reduction, Makoto Taniguchi, Yoshibumi Ueda, Michiko Matsushita, Shingo Nagaya, Chieko Hashizume, Kenta Arai, Kazuya Kabayama, Koichi Fukase, Ken Watanabe, Lusi Oka Wardhani, Kazuhiko Hayashi, Toshiro Okazaki, FASEB JOURNAL, 34:3838-3854, Mar. 2020
  • Deficiency of sphingomyelin synthase 1 but not sphingomyelin synthase 2 reduces bone formation due to impaired osteoblast differentiation, Goichi Matsumoto, Chieko Hashizume, Ken Watanabe, Makoto Taniguchi, Toshiro Okazaki, Molecular Medicine, 25:56, Dec. 2019
  • Sphingomyelin synthase 2 deficiency inhibits the induction of murine colitis-associated colon cancer, Toshio.Ohnishi, Chieko.Hashizume, Makoto.Taniguchi, Hidehiro.Furumoto, Jia.Han, Rongfen.Gao, Shinichi.Kinami, Takeo.Kosaka, Toshiro.Okazaki, The Faseb Journal, 31:3816-3830, Dec. 2017
  • Stressful learning paradigm precludes manifestation of cognitive ability in sphingomyelin synthase-2 knockout mice., Min.Wang, Osamu.Uchiumi, Hideo.Ogiso, Yuan.Shui, Jingyu.Zou, Chieko.Hashizume, Makoto.Taniguchi, Toshiro.Okazaki, Nobuo.Kato, Behavioural brain research, 319:25-30, Jan. 2017
  • A novel mechanism of thrombocytopenia by PS exposure through TMEM16F in sphingomyelin synthase 1 deficiency., Yoritaka Fujii, Makoto Taniguchi, Shingo Nagaya Yoshibumi Ueda, Chieko Hashizume, Ken Watanabe, Hiroyuki Takeya, Takeo Kosaka, Toshiro Okazaki, Blood advances, 5:4265-4277, Oct. 2021
  • Nuclear Ceramide Is Associated with Ataxia Telangiectasia Mutated Activation in the Neocarzinostatin-Induced Apoptosis of Lymphoblastoid Cells, Jun Fujita, Makoto Taniguchi, Chieko Hshizume, Yoshibumi Ueda, Shota Sakai, Tadakazu Kondo, Mayumi Hashimoto-Nishimura, Kentaro Hanada, Takeo Kosaka, Toshiro Okazaki, Molecular Pharmacology, 101:322-333, May 2022
  • Novel PKD2 Missense Mutation p.Ile424Ser in an Individual with Multiple Hepatic Cysts: A Case Report., Miura S, Niida Y, Hashizume C, Fujii A, Takagaki Y, Kusama K, Akazawa S, Minami T, Mukai T, Furuichi K, Tsuchishima M, Ueda N, Takamura H, Koya D, Ito T., 9:25, Mar. 2022
  • Surgical implanation of human adipose derived stem cells attenuates experimentally induced hepatic fibrosis in rats, 28: 143:s10020-022-00566-6, Nov. 2022